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Immunological response to Chinese herbal medicine in food allergy

食物过敏中草药的免疫反应

基本信息

批准号：
8468633
负责人：
Julie Wang
金额：
$ 12.95万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-10 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8468633
关键词：
Accident and Emergency department Accounting Address Adult Adverse effects Affect Aftercare Allergic Allergic Disease Allergic Reaction Allergy to peanuts Anaphylaxis Animal Model Anti-Allergic Agents Anti-Inflammatory Agents Anti-inflammatory Basophils Binding Cell surface Cells Child China Chinese Herbs Chinese Traditional Medicine Chronic Clinical Complex Controlled Clinical Trials Country Data Disease Disease remission Double-Blind Method Epitopes Expenditure Fishes Flow Cytometry Food Food Allergy Herbal Formula-1 Food Hypersensitivity Goals Health Healthcare Herb Herbal Medicine Hospitals Human Hypersensitivity IgE Immunoassay Immunoglobulin G Immunologics In Vitro Individual Instruction Investigation Life Measures Milk Hypersensitivity Modeling Mononuclear Mus Nut Hypersensitivity Nuts Oral Outcome Patients Peanuts - dietary Peptides Peripheral Phase I Clinical Trials Phytotherapy Placebo Control Prevalence Principal Investigator Process Production Property Protocols documentation Quality of life Randomized Safety Shellfish Signal Transduction Specificity Surface Tablets Testing Trees United States Visit Wheat aqueous base clinical effect clinical efficacy dietary supplements egg food allergen food allergy herbal formula food challenge mast cell pancreatic secretory trypsin inhibitor I response soy

项目摘要

Food allergy affects as many as 6% of young children and 3-4% of adults.(1,2) Peanut allergy is the leading cause of food-induced anaphylaxis treated in hospital emergency departments in the United States (3) and peanut and tree nut allergies account for approximately 80% of fatal and near-fatal anaphylactic reactions.(4-6) While the majority of children outgrow their allergy to milk, egg, wheat, and soy, allergies to peanut, tree nuts, fish and shellfish are often life-long. Currently, there are no treatments that can cure or provide long-term remission from food allergy. Traditional Chinese Medicine (TCM) has been used to treat various diseases for thousands of years. Chinese herbal medicine, particularly in the form of formulas that are composed of several herbs, is one of the major components in the practice of TCM. The Food Allergy Herbal Formula (FAHF-2) is a 9 herb formula (7-14) that has been demonstrated to be safe and effective in a murine model of peanut allergy.(15,16) Furthermore, FAHF-2 appears to be safe and well-tolerated in food-allergic patients. This protection from anaphylaxis in the murine model is associated with decreased IgE, increased lgG2a, decreased peripheral basophils, and decreased cell surface expression of FceRI on mast cells and basophils. Thus, we hypothesize that FAHF-2 is a safe and effective herbal therapy for food allergy and this protection is associated with suppression of food specific IgE while increasing food-specific IgG (and lgG4), decreased IgE epitope diversity, and suppression of basophil numbers and function. These aims will be investigated in a double-blind, randomized, placebo-controlled clinical trial, using standard protocols, including double-blind, placebo-controlled oral food challenges, to evaluate clinical outcomes including long- term efficacy. RELEVANCE (See instructions): The goal of this study will be to validate the clinical efficacy of Chinese herbal medicine in food allergies and to elucidate the mechanisms of action of this herbal formula. This potential therapy has significant advantages over other treatments currently under investigation because it is administered orally, has a high safety profile, and may provide long-term protection from anaphylaxis.

食物过敏影响多达6%的幼儿和3-4%的成年人。（1，2）花生过敏是美国医院急诊室治疗的食物引起过敏反应的主要原因 (3)花生和树坚果过敏占致命和近致命过敏性疾病的约80%。反应. (4-6)虽然大多数儿童对牛奶，鸡蛋，小麦和大豆过敏，花生、坚果、鱼和贝类的寿命通常是很长的。目前，没有治疗方法可以治愈或长期缓解食物过敏。中国传统医学（TCM）已被用于治疗各种疾病数千年。中草药，特别是由几种草药组成的配方，是中医实践中的主要组成部分。食物过敏草药配方（FAHF-2）是一种9草药式（7-14）的化合物，其已在花生的鼠模型中被证明是安全和有效的过敏(15此外，FAHF-2在食物过敏患者中似乎是安全的且耐受性良好。这在鼠模型中对过敏反应的保护与IgE降低，IgG 2a增加，外周嗜碱性粒细胞减少，肥大细胞上FceRI的细胞表面表达减少，嗜碱性粒细胞因此，我们假设FAHF-2是一种安全有效的食物过敏草药疗法，保护作用与食物特异性IgE的抑制同时增加食物特异性IgG（和IgG 4）有关，降低IgE表位多样性，抑制嗜碱性粒细胞数量和功能。这些目标将是在一项双盲、随机、安慰剂对照的临床试验中进行了研究，使用标准方案，包括双盲、安慰剂对照的口服食物挑战，以评估临床结局，包括长期- 有效期。相关性（参见说明）：本研究的目的是验证中草药治疗食物过敏的临床疗效，以阐明该草药配方的作用机制。这种潜在的治疗方法具有重要意义。与目前正在研究的其他治疗方法相比，由于它是口服给药，安全性，并可提供长期保护，防止过敏反应。