CETRIZINE VERSUS DIPHENHYDRAMINE IN TREATMENT OF FOOD ALLERGIC REACTIONS

西替嗪与苯海拉明治疗食物过敏反应

• 批准号: 7953725
• 负责人: Julie Wang
• 金额: $ 0.15万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953725
• 关键词: Acute; Adverse effects; Allergic; Allergic Reaction; Antihistamines; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diphenhydramine; Food; Funding; Generations; Grant; Institution; Patients; Reaction; Research; Research Personnel; Resources; SK-Diphenhydramine; Sedation procedure; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 2/27/2008 Hypothesis: Cetirizine (Zyrtec) provides more rapid relief and less sedation compared to Benadryl in the treatment of acute allergic food reactions. Diphenhydramine (Benadryl) has been commonly used as the antihistamine of choice for acute food allergic reactions given its quick onset of action and ready availability. However, sedation is a common side effect of diphenhydramine, which can complicate the assessment of a patient being treated for an acute allergic food reaction. Cetirizine (Zyrtec) is a newer generation antihistamine with a longer duration of action and less sedating side effects. A direct comparison of the onset of action and side effect profile of cetirizine to diphenhydramine has not been made for the treatment of allergic food reactions. If cetirizine offers quick onset of antihistaminic relief with less sedation compared to diphenhydramine, cetirizine would be an attractive alternative to diphenhydramine in the treatment of acute food allergic reactions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 2/27/2008 假设： 西替利嗪（Zyrtec）在治疗急性过敏性食物反应时，与苯那君相比，可提供更快速的缓解和更少的镇静作用。 苯海拉明（Benadryl）因其起效快且易于获得而常用作急性食物过敏反应的抗组胺药。 然而，镇静是苯海拉明的常见副作用，这可能使正在治疗急性过敏性食物反应的患者的评估复杂化。 西替利嗪（Zyrtec）是新一代抗组胺药，具有更长的作用时间和更少的镇静副作用。 尚未对西替利嗪与苯海拉明治疗食物过敏反应的起效时间和副作用特征进行直接比较。 如果与苯海拉明相比，西替利嗪提供快速起效的抗组胺缓解，镇静作用较少，则西替利嗪将是苯海拉明治疗急性食物过敏反应的有吸引力的替代品。