2013 Cell Biology of Megakaryocytes and Platelets GRC & GRS

2013年巨核细胞和血小板的细胞生物学GRC

• 批准号: 8450490
• 负责人: KATYA RAVID
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8450490
• 关键词: Academia; Attention; Basic Science; Biology; Blood Platelets; Cardiovascular Diseases; Cardiovascular Pathology; Caring; Cells; Cellular biology; Coagulation Process; Collaborations; Communities; Coupled; Cytoskeleton; Development; Discipline; Disease; Faculty; Future; Goals; Health; Hematological Disease; Inflammatory; Institutes; Island; Knowledge; Learning; Medical; Megakaryocytes; Megakaryocytopoieses; Mentors; Methods; Mexico; MicroRNAs; Mission; Myeloproliferative disease; Myocardial Infarction; Names; Oral; Pathologic; Pathology; Pharmacologic Substance; Prevention; Process; Request for Applications; Research; Research Personnel; Running; Science; Scientist; Signal Transduction; Solid; Stroke; Talents; Texas; Thrombopoiesis; Thrombosis; Thrombus; Time; Training; abstracting; bench to bedside; career; cost; embryonic stem cell; experience; frontier; genome wide association study; immune function; improved; innovation; insight; interdisciplinary approach; interest; meetings; mimetics; novel; novel therapeutics; programs; public health relevance; screening; sound; symposium; thrombocytosis; tool

DESCRIPTION (provided by applicant): Abnormal thrombopoiesis and thrombosis contribute to an array of hematological and cardiovascular pathologies, thus, requiring continued research and educational efforts. The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them. This will be the 5th biennial meeting that brings together two groups of scientists with complimentary goals and interests. Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in MKs and platelets. This plan then leads smoothly to a session centered on discoveries related to MK and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected from submitted abstracts. There are several innovative aspects to the planned meeting, including 1. The sessions cover within the same cluster processes that govern MK and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives; 2. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm; 3. Emphasis on multidisciplinary approaches is exemplified in several sessions; and 4. Inclusion, for the first time, of a session titled: Breaking Paradigms in MK and Platelet Biolog provides opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. The retention of the Gordon Research Seminar (GRS) for the 2013 meeting is important. This venue encourages promising trainees to participate more visibly in the program and possibly be encouraged to continue and develop a career in MK and platelet biology. A novel aspect in the GRS plan involves a talk on a historical overview of discovery in MK/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies. Taken together, we believe that the planned GRC/GRS represent the Frontiers of Science for our discipline, with keen attention to mentoring. The GRS/GRC meetings take place from March 9-10th and 10-15th, 2013, respectively, at the historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees.

描述（由申请人提供）：异常血小板生成和血栓形成导致一系列血液学和心血管病理学，因此，需要持续的研究和教育工作。巨核细胞和血小板细胞生物学戈登研究会议（GRC）是专注于巨核细胞（MK）和血小板产生的生物学的首要科学会议。这将是第五届两年一度的会议，汇集了两组具有互补目标和兴趣的科学家。我们的会议将开始与巨核细胞和血小板生成的过程，包括从诱导多能和胚胎干细胞，移动到新的计算和筛选方法来研究这些过程，过渡到这些细胞的细胞生物学在细胞骨架的背景下，然后到新发现的信号，炎症和免疫功能的MK和血小板。这个计划然后顺利地导致一个会议集中在有关MK和血小板病理学的发现。此外，还有一整个会议专门介绍从提交的摘要中选出的热门话题。计划中的会议有几个创新方面，包括1.这些会议涵盖了管理MK和血小板发育和功能的相同集群过程，因此，允许具有重叠兴趣的两个受众融合，进一步增加观点交流; 2.翻译潜力在一个新的会议中得到了说明，该会议的标题是：从实验室到床边，以及会谈，例如与骨髓增生性肿瘤相关的血小板增多症的新治疗选择; 3.强调多学科的方法是例证在几个会议;和4。包括，第一次，一个会议题为：打破MK和血小板生物学的范式提供了机会，了解和讨论新的范式，挑战该领域的旧概念。为2013年会议保留戈登研究研讨会（GRS）很重要。这个场地鼓励有前途的学员更明显地参与该计划，并可能被鼓励继续和发展MK和血小板生物学的职业生涯。GRS计划的一个新方面涉及MK/血小板生物学发现的历史概述。学员提交的摘要将由一个小组评分，并选择口头报告，其中一些也将在GRC的热门话题下提出。与研究人员的圆桌讨论将提供与学术界和制药公司职业相关的指导。总的来说，我们相信计划中的GRC/GRS代表了我们学科的科学前沿，并非常关注指导。GRS/GRC会议分别于2013年3月9日至10日和10日至15日在位于墨西哥湾的德克萨斯州加尔维斯顿岛的历史悠久的加尔维斯酒店举行。凭借广阔的海滩和岛上及附近众多景点的独特环境，这将是所有与会者的一个令人兴奋和难忘的场所。