2013 Cell Biology of Megakaryocytes and Platelets GRC & GRS

描述(申请人提供)：异常的血栓生成和血栓形成导致一系列血液和心血管疾病，因此，需要持续的研究和教育努力。关于巨核细胞和血小板细胞生物学的戈登研究会议(GRC)是主要的科学会议，重点关注巨核细胞(MK)和由此产生的血小板的生物学。这将是第五次两年一度的会议，将目标和兴趣互补的两组科学家聚集在一起。我们的会议将从调控巨核细胞和血小板生成的过程开始，包括从可诱导的多能干细胞和胚胎干细胞，转移到新的计算和筛选方法来研究这些过程，过渡到细胞骨架背景下这些细胞的细胞生物学，然后到新发现的巨核细胞和血小板的信号、炎症和免疫功能。然后，该计划顺利地将会议引向以MK和血小板病理学相关发现为中心的会议。此外，还有一整节课专门介绍热门话题，从提交的摘要中挑选出来。计划中的会议有几个创新方面，包括：1.会议涉及管理MK和血小板发育和功能的相同集群进程，因此，允许具有重叠兴趣的两个受众汇聚，进一步增加观点的交流；2.翻译潜力在题为：从长凳到床边的新会议中得到说明，并进行演讲，例如关于骨髓增生性肿瘤相关的血小板增多症的新治疗选择；3.在几个会议中举例说明了对多学科方法的重视；4.首次列入题为：MK和血小板生物学中的打破范式的会议，为了解和讨论挑战该领域旧概念的新范式提供了机会。为2013年会议保留戈登研究研讨会(GRS)很重要。这个场地鼓励有前途的受训者更明显地参与该计划，并可能鼓励他们继续并在MK和血小板生物学领域发展自己的事业。GRS计划的一个新方面涉及到对MK/血小板生物学发现的历史概述的演讲。受训者提交的摘要将由评审团评分，并被选为口头报告，其中一些也将在GRC的热门话题下发表。与调查人员的圆桌讨论将提供与学术界和制药公司职业相关的指导。综上所述，我们相信，计划中的GRC/GRS代表着我们学科的科学前沿，并密切关注指导。GRS/GRC会议分别于2013年3月9日至10日和10日至15日在位于墨西哥湾的德克萨斯州加尔维斯顿岛历史悠久的加尔韦斯酒店举行。这里拥有宽阔的海滩和岛上及附近众多景点的独特环境，对于所有与会者来说，这将是一个令人兴奋和难忘的场所。

DESCRIPTION (provided by applicant): Abnormal thrombopoiesis and thrombosis contribute to an array of hematological and cardiovascular pathologies, thus, requiring continued research and educational efforts. The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes (MKs) and the platelets that arise from them. This will be the 5th biennial meeting that brings together two groups of scientists with complimentary goals and interests. Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in MKs and platelets. This plan then leads smoothly to a session centered on discoveries related to MK and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected from submitted abstracts. There are several innovative aspects to the planned meeting, including 1. The sessions cover within the same cluster processes that govern MK and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives; 2. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm; 3. Emphasis on multidisciplinary approaches is exemplified in several sessions; and 4. Inclusion, for the first time, of a session titled: Breaking Paradigms in MK and Platelet Biolog provides opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. The retention of the Gordon Research Seminar (GRS) for the 2013 meeting is important. This venue encourages promising trainees to participate more visibly in the program and possibly be encouraged to continue and develop a career in MK and platelet biology. A novel aspect in the GRS plan involves a talk on a historical overview of discovery in MK/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies. Taken together, we believe that the planned GRC/GRS represent the Frontiers of Science for our discipline, with keen attention to mentoring. The GRS/GRC meetings take place from March 9-10th and 10-15th, 2013, respectively, at the historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees.