The Wisconsin State Laboratory of Hygiene?s Proposal to Add to the Capability and

威斯康星州立卫生实验室关于增加能力和

• 批准号: 8299388
• 负责人: MICHAEL Frederick ARNDT
• 金额: $ 24.15万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299388
• 关键词: Wisconsin; State; Laboratory; Hygiene; Proposal

Project Summary/Abstract The Radiochemistry Unit at the Wisconsin State Laboratory of Hygiene plans on working with the FDA and other FERN laboratories to extend current rapid-screening methods to more food matrices, to develop new rapid-screening methods, and to extend and develop methods to identify specific radionuclides. Some work intensive steps-like wet-ashing and chromatography-require considerable attention by an analyst. It is proposed that these steps be automated to increase the sample preparation rate and to allow analysts to spend more time on other tasks. The Radiochemistry Unit will remain in a state of preparedness, for both emergency and routine surveillance samples, by keeping a sufficient stock of supplies, by periodic preventative maintenance of instrumentation, and by keeping an inventory of spare parts for the instrumentation. It is proposed that three computer programs be developed. One program already performs several tasks, one is partially developed, and one has not yet been started. The first program has been developed to calculate a sample's gross alpha activity from its known alpha emitters. The calculated gross alpha activity can be compared to the experimental gross alpha activity to determine whether all of a sample's alpha activity has been accounted for. The program can also be used interactively to perform activity calculations and to help identify unknown radionuclides. One objective is to further develop this program to calculate a sample's gross beta activity from its known beta emitters. The second program has been partially developed to fit the peaks of alpha spectra in cases where there is considerable peak overlap. In some cases, peak overlap in spectra cannot be avoided; in other cases, peak overlap is the result of contamination or excessive broadening of the peaks, due to a high precipitate mass. In such cases, the peak fit program can be used to obtain more accurate information than could be obtained using a region of interest approach. It is proposed that this program be completed. It is proposed that a third program be written to optimize the use of labor and resources during and emergency situation. Any or these programs will be available to other FERN laboratories.

项目总结/摘要 威斯康星州卫生学国家实验室的放射化学单位 计划与FDA和其他FERN实验室合作， 快速筛选方法，以更多的食品基质，开发新的快速筛选 该项目的目的是确定放射性核素的种类和方法，并扩大和发展确定特定放射性核素的方法。 一些工作密集的步骤，如湿灰化和色谱法，需要 分析师的高度关注。建议将这些步骤 自动化，以提高样品制备速率，并允许分析人员 把更多的时间花在其他任务上。放射化学股将继续处于 为紧急和常规监测样品做好准备， 通过定期预防性维护， 仪器仪表，并保持备件库存， 仪器仪表 建议开发三个计算机程序。一个程序 已经执行了几项任务，一项是部分开发，另一项尚未开发。 已经开始了。第一个程序已经开发出来，以计算样品的 已知的α放射源的总α放射性。计算的总阿尔法 可以将活性与实验的总α活性进行比较以确定 是否所有样本的阿尔法活性都被计算在内。该程序可以 也可以交互式地用于执行活动计算，并帮助识别 未知的放射性核素一个目标是进一步发展这一方案， 根据已知的β发射体计算样本的总β放射性。第二 程序已经部分开发，以适应α谱的情况下， 其中存在相当大的峰重叠。在一些情况下，在一些实施例中， 光谱无法避免;在其他情况下，峰重叠是 由于高沉淀物，污染或峰过度增宽 马萨诸塞州在这种情况下，可以使用峰拟合程序来获得更准确的结果。 这是可以使用感兴趣区域方法获得的信息。是 建议完成这个项目。有人建议，第三个方案是 在紧急情况下优化人力和资源的使用 形势任何或这些程序将提供给其他FERN实验室。