The Wisconsin State Laboratory of Hygiene?s Proposal to Add to the Capability and

威斯康星州立卫生实验室关于增加能力和

• 批准号: 8493972
• 负责人: MICHAEL Frederick ARNDT
• 金额: $ 22.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8493972
• 关键词: Wisconsin; State; Laboratory; Hygiene; Proposal

Project Summary/Abstract The Radiochemistry Unit at the Wisconsin State Laboratory of Hygiene plans on working with the FDA and other FERN laboratories to extend current rapid-screening methods to more food matrices, to develop new rapid-screening methods, and to extend and develop methods to identify specific radionuclides. Some work intensive steps-like wet-ashing and chromatography-require considerable attention by an analyst. It is proposed that these steps be automated to increase the sample preparation rate and to allow analysts to spend more time on other tasks. The Radiochemistry Unit will remain in a state of preparedness, for both emergency and routine surveillance samples, by keeping a sufficient stock of supplies, by periodic preventative maintenance of instrumentation, and by keeping an inventory of spare parts for the instrumentation. It is proposed that three computer programs be developed. One program already performs several tasks, one is partially developed, and one has not yet been started. The first program has been developed to calculate a sample's gross alpha activity from its known alpha emitters. The calculated gross alpha activity can be compared to the experimental gross alpha activity to determine whether all of a sample's alpha activity has been accounted for. The program can also be used interactively to perform activity calculations and to help identify unknown radionuclides. One objective is to further develop this program to calculate a sample's gross beta activity from its known beta emitters. The second program has been partially developed to fit the peaks of alpha spectra in cases where there is considerable peak overlap. In some cases, peak overlap in spectra cannot be avoided; in other cases, peak overlap is the result of contamination or excessive broadening of the peaks, due to a high precipitate mass. In such cases, the peak fit program can be used to obtain more accurate information than could be obtained using a region of interest approach. It is proposed that this program be completed. It is proposed that a third program be written to optimize the use of labor and resources during and emergency situation. Any or these programs will be available to other FERN laboratories.

项目摘要/摘要 威斯康星州立卫生实验室放射化学组 计划与FDA和其他蕨类实验室合作，延长目前的 更多食品基质的快速筛选方法，开发新的快速筛选方法 方法，并推广和发展识别特定放射性核素的方法。 一些密集的工作步骤--如湿法灰化和层析--需要 一位分析家对此相当关注。建议将这些步骤 自动化以提高样品制备率并允许分析员 把更多的时间花在其他任务上。放射化学股将保持在 对紧急和常规监测样本的准备，通过保持 通过定期预防性维护提供充足的供应品 仪器，并通过保持备件库存 仪器仪表。 建议开发三个计算机程序。一个程序 已经执行了几个任务，一个是部分开发的，另一个还没有 已经开始了。第一个程序已经开发出来，用来计算样本的 已知的阿尔法发射体的阿尔法总活度。计算出的总阿尔法 活度可以与实验的总阿尔法活度进行比较，以确定 样本的所有阿尔法活动是否已被考虑在内。该程序可以 还可以交互地用于执行活动计算并帮助确定 未知的放射性核素。一个目标是进一步发展这一计划，以 根据已知的贝塔辐射体计算样本的总贝塔活度。第二 已经部分开发了程序来拟合各种情况下的阿尔法谱峰 其中有相当大的峰值重叠。在某些情况下，峰值重叠 光谱无法避免；在其他情况下，峰重叠是 由于高沉淀物引起的峰的污染或过度加宽 质量。在这种情况下，可以使用峰值拟合程序来获得更准确的结果 这比使用感兴趣区域方法所能获得的信息要多。它是 建议完成这一计划。有人提议第三个方案是 旨在优化人力和资源在紧急情况下的使用 情况。其他蕨类实验室也可以使用任何或这些项目。