The Johns Hopkins Cancer Nanotechnology Training Center

约翰霍普金斯大学癌症纳米技术培训中心

• 批准号: 8548285
• 负责人: Hai-Quan Mao
• 金额: $ 28.98万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-03 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8548285
• 关键词: Academia; Address; Advanced Malignant Neoplasm; Antibodies; Biochemistry; Biological; Biological Process; Biological Sciences; Biology; Boxing; Breeding; Cancer Biology; Cancer Center; Cancer Diagnostics; Cell physiology; Cellular biology; Clinical; Comprehensive Cancer Center; Detection; Development; Diagnostic; Discipline; Educational Curriculum; Engineering; Equilibrium; Ethics; Faculty; Fellowship; Fostering; Foundations; Future; Genetic; Genetic Markers; Hereditary Disease; Hospitals; Housing; Human; Hybrids; Individual; Industry; Institutes; Journals; Laboratories; Laboratory Research; Lead; Learning; Malignant Neoplasms; Malignant neoplasm of pancreas; Medicine; Mentors; Modality; Modification; Molecular and Cellular Biology; Monitor; Nanostructures; Nanotechnology; Output; Patients; Pattern; Pharmaceutical Preparations; Physics; Positioning Attribute; Protein Engineering; Public Health; Recruitment Activity; Research; Resources; Rotation; Science; Scientist; Series; Signal Pathway; Small Interfering RNA; Surface; System; Techniques; Technology; Therapeutic; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Viral; Writing; base; biological systems; cancer cell; cancer genetics; clinical conference; design; disease phenotype; epigenetic marker; frontier; fundamental research; graduate student; human disease; improved; in vivo Cellular and Molecular Imaging Centers; molecular imaging; nanobiotechnology; nanoparticle; nanoscale; novel; oncology; outcome forecast; pre-doctoral; prevent; programs; responsible research conduct; symposium; tool; web site

Summary We propose to create a predoctoral training program in nanotechnology for cancer medicine - The Johns Hopkins Cancer Nanotechnology Training Center (CNTC) - that will be positioned at the interface of cancer biology and nanotechnology and will establish a unique national resource with interdisciplinary and synergistic programs in both fundamental and translational research in cancer medicine. The CNTC will foster predoctoral fellows who will be trained across disciplines to lay foundations for technologies that will enable an inside-view of cancer cell functions as opposed to the limited black-box input-output techniques currently used, introduce new modalities for molecular imaging, develop new high-throughput diagnostic tools, and engineer novel viral and non-viral delivery systems to treat human cancers. CNTC fellows will view interactions between nanostructures and biological systems in physical, biological, and biomedical terms and will become adept at emerging concepts in biomolecular engineering, protein engineering, materials synthesis and surface modification, which are required to create nanotechnology to elucidate and monitor in real-time signaling pathways that lead to cancer transformation. CNTC fellows will also develop novel cancer diagnostics to evaluate each individual patient's prognosis and optimal treatment, based upon the patients' genetic and epigenetic markers and disease phenotype and therapeutics that are selected and optimized for each individual patient. The CNTC will train a cadre of predoctoral fellows for a future in research in academia and research laboratories in industry. Through independent proposal writing, the CNTC will emphasize early independence in research. CNTC fellows will be able to take advantage of research and clinical resources at the Johns Hopkins Hospital, the NCI- designated Sidney Kimmel Comprehensive Cancer Center, the Ludwick Center for Cancer Genetics and Therapeutics, The Sol Goldman Pancreatic Cancer Center, the In Vivo Cellular and Molecular Imaging Center, and the Johns Hopkins Engineering in Oncology Center PSOC as well as the unique educational resources and experimental facilities of the Johns Hopkins Institute for NanoBioTechnology, where the CNTC will be administratively housed.

总结 我们建议创建一个在纳米技术的癌症医学博士前培训计划-约翰霍普金斯癌症纳米技术培训中心（CNTC）-将定位在癌症生物学和纳米技术的接口，并将建立一个独特的国家资源与跨学科和协同计划在癌症医学的基础和转化研究。CNTC将培养博士前研究员，他们将接受跨学科的培训，为技术奠定基础，这些技术将使癌细胞功能的内部视图成为可能，而不是目前使用的有限的黑箱输入输出技术，引入新的分子成像模式，开发新的高通量诊断工具，并设计新的病毒和非病毒传递系统来治疗人类癌症。CNTC研究员将查看物理，生物和生物医学方面的纳米结构和生物系统之间的相互作用，并将成为在生物分子工程，蛋白质工程，材料合成和表面改性，这是需要创建纳米技术来阐明和实时监测信号通路，导致癌症转化的新兴概念熟练。CNTC研究员还将开发新的癌症诊断方法，以评估每个患者的预后和最佳治疗，基于患者的遗传和表观遗传标记以及为每个患者选择和优化的疾病表型和治疗方法。国家技术中心将培养一批博士前研究员骨干，以便将来在学术界和工业界的研究实验室进行研究。通过独立撰写提案，CNTC将强调研究的早期独立性。CNTC研究员将能够利用约翰霍普金斯医院，NCI指定的西德尼金梅尔综合癌症中心，路德威克癌症遗传学和治疗中心，索尔戈德曼胰腺癌中心，体内细胞和分子成像中心的研究和临床资源，和约翰霍普金斯肿瘤工程中心PSOC以及约翰霍普金斯纳米生物技术研究所独特的教育资源和实验设施，全国过渡委员会的行政办公地点