Randomized Placebo-Controlled Trial of Hydrocortisone in PTSD Prophylaxis

描述(由申请人提供)：拟议项目的主要目标是确定一次注射90-140毫克氢化可的松(HCORT)(按体重比例)的效果，通过运用与创伤事件暴露后6小时内恢复有关的生物机制来预防随后发生的创伤后应激障碍(PTSD)。该项目还试图通过评估随机服用Hcort或安慰剂的人随着时间的推移，检查与创伤暴露和康复相关的生物和心理变化。拟议的办法是调查人员在各自的研究环境中开展的与复原机制有关的工作的结果。

DESCRIPTION (provided by applicant): The primary aim of the proposed project is to determine the efficacy of a single injection of 90-140 mg (proportioned to body weight) of hydrocortisone (Hcort) to prevent the subsequent development of posttraumatic stress disorder (PTSD) by engaging biological mechanisms associated with recovery within 6 hours after exposure to a traumatic event. This project also seeks to examine biological and psychological alterations associated with trauma exposure and recovery by evaluating these over time in persons randomized to Hcort or placebo. The proposed approach is an outgrowth of work performed by the investigators in their respective research settings pertaining to mechanisms involved in recovery.