Randomized Placebo-Controlled Trial of Hydrocortisone in PTSD Prophylaxis

描述（由申请人提供）：拟议项目的主要目的是确定单次注射90-140毫克（与体重成比例）氢化可的松（Hcort）的功效，通过参与与暴露于创伤事件后6小时内恢复相关的生物机制，预防创伤后应激障碍（PTSD）的后续发展。该项目还试图通过对随机接受Hcort或安慰剂治疗的患者进行长期评估，来检查与创伤暴露和恢复相关的生物学和心理变化。所提出的方法是研究人员在各自的研究环境中所进行的有关恢复机制的工作的结果。

DESCRIPTION (provided by applicant): The primary aim of the proposed project is to determine the efficacy of a single injection of 90-140 mg (proportioned to body weight) of hydrocortisone (Hcort) to prevent the subsequent development of posttraumatic stress disorder (PTSD) by engaging biological mechanisms associated with recovery within 6 hours after exposure to a traumatic event. This project also seeks to examine biological and psychological alterations associated with trauma exposure and recovery by evaluating these over time in persons randomized to Hcort or placebo. The proposed approach is an outgrowth of work performed by the investigators in their respective research settings pertaining to mechanisms involved in recovery.