Molecular Characterization of Aggressive Colon Cancers of African-American.......

非裔美国人侵袭性结肠癌的分子特征......

• 批准号: 8568033
• 负责人: Temesgen Samuel
• 金额: $ 2.49万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8568033
• 关键词: 3-Dimensional; African American; Alabama; Award; BCL2 gene; Cancer Center; Caucasians; Caucasoid Race; Clinical; Codon Nucleotides; Collaborations; Colon Adenocarcinoma; Colon Carcinoma; Colorectal Cancer; Communities; Diagnosis; Diagnostic Neoplasm Staging; Disease; Ethnic Origin; Faculty; Funding; Future; Gene Expression; Genes; Goals; Hospitals; In Vitro; Incidence; Lead; Location; Microsatellite Repeats; Minority-Serving Institution; Modeling; Molecular; Molecular Profiling; Morehouse School of Medicine; Not Hispanic or Latino; Nuclear; Outcome; Patients; Phenotype; Predictive Factor; Predictive Value; Prognostic Factor; Rectal Adenocarcinoma; Recurrence; Relative (related person); Reporting; Research Personnel; Risk; S100A11 gene; Schools; Single Nucleotide Polymorphism; Specimen; Staging; Tissues; Tumor stage; Universities; anticancer research; arginylproline; base; cancer cell; cancer health disparity; career; experience; improved; molecular marker; mortality; novel; patient population; pre-clinical; prognostic; racial and ethnic; racial difference; response; translational study; tumor; validation studies

This Full Project of the MSM/TU/UAB Partnership proposes to conduct preclinical translational studies in colorectal cancer to determine the prognostic and predictive value of a panel of novel molecular markers in colonic adenocarcinoma (CAC) tissues collected from African-American (AA) and non-Hispanic Caucasian (white) patients who underwent treatment at MSM and UAB hospitals. This proposal is also intended to develop the career of Dr. Temesgen Samuel, a junior faculty at Tuskegee Univeristy, who is seeking more experience in understanding the basis for cancer health disparities. Further, this project will continue the existing successful collaboration, established during the currently funded U54 Partnership award, between Dr. Harvey Bumpers of Morehouse School of Medicine and Dr. Upender Manne of UAB. The preliminary results of these collaborative studies show a disparity in gene expression profiles of aggressive microsatellite stable (MSS) phenotypes of CACs of AAs and whites. Based on these findings, the current hypothesis is that the MSS phenotypes of CACs from AAs and whites are different, and their value in assessing the clincal outcomes varies with tumor stage and location. To this hypothesis, Aim-1 will evaluate colon cancer specimens from 447 AAs and 563 whites for expression profiles of genes differentially expressed in colon cancers with MSS phenotypes. The expression profiles will be correlated with tumor stage, disease recurrence, overall and disease-specific survival, and response to therapy based on ethnicity; Aim-2 will assess the mutational and expression status of S100A11 and RPH3AL in CACs of AAs and whites, and the mutational status and expression levels will be correlated with clinicopatholgoic features and with the clinical outcomes of AAs and whites; and Aim-3 will determine the mechanistic functions of S100A11 and RPH3AL in colon cancer cells in vitro by generating colon cancer cells stably inhibiting S100A1 or expressing RPH3AL, in 3-dimensional tumor models. These studies will identify predictive/prognostic molecular signatures of MSS phenotypes of CACs of AAs and specifically elucidate the underiying molecular mechanisms of colon cancers of AAs and whites.

MSM/TU/UAB伙伴关系的完整项目建议在以下方面进行临床前转化研究