Addressing Global TB Prevention and Control in All Populations and Strengthening

描述（由申请人提供）：CRDF Global将与美国疾病控制中心（CDC）消除结核病司/国际研究和项目分支（DTBE）合作，在全球多达35个国家发起并管理结核病（TB）相关研究和项目活动的多样化组合。DTBE工作包括结核病研究和结核病控制、治疗和预防。CRDF Global将与选定的伙伴机构（由CDC确定或由CRDF Global与CDC合作确定）合作，征求各种结核病相关研究活动的建议，安排对建议进行外部技术审查，并与CDC协调供资决定。对于选定的项目，CRDF Global将作为信托和行政代理，向外国政府和非政府组织及个人以及美国国内非政府组织（次级接受者）或个人支付资金。次级受援者将与疾病预防控制中心合作实施结核病消除方案。根据疾病预防控制中心、美国国内合作伙伴和国际合作伙伴共同制定的协议和工作计划，CRDF Global将与外国政府和组织联络，以获得所有必要的政府、法律的和组织授权，并建立机制来管理已批准的次级受援方预算中规定的项目资金。CRDF Global将采购设备、材料和供应品，包括在可能的情况下免税进口和清关，并支持相关物流，如旅行、会议、培训、运输和通信。疾病控制和预防中心/DTBE将是向这些项目和活动提供技术援助的积极伙伴。次级接受者将在疾病预防控制中心的积极参与和CRDF Global的财务监督下负责具体项目。需要支持的活动包括但不限于：实施和评估快速诊断新战略、业务研究、大量培训、改进检测和预防结核病机构传播的措施、改进结核病治疗和加强病例检测、监测和报告。其他措施包括：对外国出生的人口、艾滋病毒/艾滋病感染者等弱势群体、儿童、老年人、耐药结核病患者、收容人口和贫困人口进行基本流行病学调查。

DESCRIPTION (provided by applicant): CRDF Global will initiate and manage a diverse portfolio of Tuberculosis (TB)-related research and programmatic activities in up to 35 countries worldwide, for and in cooperation with the Division of TB Elimination/ International Research and Programs Branch (DTBE) of the U.S. Centers for Disease Control (CDC). DTBE work consists of TB research and TB control, treatment and prevention. CRDF Global will engage selected partner institutions (identified by CDC or by CRDF Global in collaboration with CDC) to solicit proposals for a variety of TB- related research activities, arrange for external technical review of proposals, and coordinate with CDC on funding decisions. For selected projects, CRDF Global will serve as a fiduciary and administrative agent to disburse funds to foreign governmental and non-governmental organizations and individuals, and U.S. domestic non-governmental organizations (sub- recipients) or individuals. The sub-recipients in collaboration with CDC will implement TB elimination programs. Based on protocols and work plans developed jointly by CDC, U.S. domestic partners and international counterparts, CRDF Global will liaise with foreign governments and organizations to obtain all necessary governmental, legal, and organizational authorizations and establish mechanisms to administer project funds as provided for in approved sub-recipient budgets. CRDF Global will procure equipment, materials, and supplies, including tax-exempt importation and customs clearance when and where possible, and support related logistics such as travel, meetings, training, shipping, and communications. CDC/DTBE will be an active partner in providing technical assistance to these projects and activities. The sub-recipients will be responsible for specific projects with the active involvement of CDC and financial oversight of CRDF Global. Examples of activities to be supported include, but are not limited to: implementing and evaluating new strategies for rapid diagnosis, operational research, numerous trainings, improved measures to detect and prevent institutional transmission of TB, improve TB treatment and strengthen case detection, surveillance and reporting. Other measures include: basic epidemiological investigations of foreign born populations, vulnerable populations such as people living with HIV/AIDS (PLWHIV), children, the elderly, persons with drug-resistant TB, institutionalized populations and those living in poverty.