Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

沙阿博士是一名内科科学家，有15年领导以患者为导向的研究(POR)的经验 全球结核病的诊断、治疗和预防，包括耐药结核病和结核病/艾滋病毒联合 感染。她在美国和国际公共卫生项目中的经验，包括疾病中心 控制与预防(CDC)，在那里她接受了十年的培训和工作，为 将研究整合到政策和病人护理中。这个K24奖项将让她提升和扩大她的能力 通过为高级学习方法培训提供重要的保护时间，在POR中提供成功的指导 结核病传播，并制定一个结构化的指导计划。在世界范围内，结核病是主要的死亡原因。 在艾滋病毒携带者中，耐药结核病威胁着数十年来在结核病和艾滋病毒控制方面的进展。 耐药结核病流行主要是由耐药菌株的人与人之间传播驱动的，以及 迫切需要创新的方法来提高我们对结核病传播的了解，以有效地指导 干预措施。同样，有必要对下一代科学家进行多学科结核病/艾滋病毒和 全球健康POR。沙阿博士由美国国立卫生研究院、盖茨基金会和疾病控制与预防中心支持的强有力的研究计划 提供令人兴奋的培训机会，吸引对多学科结核病和艾滋病毒POR感兴趣的学员。她 在结核病和艾滋病毒临床的不同领域指导美国和国际学员方面有着良好的记录 研究，她的许多导师都追求学术生涯和K奖。此外，通过她 担任NIH P30埃默里/佐治亚州结核病研究促进中心临床核心主任 作为D43和T32项目的导师，她很有能力提供出色的研究和培训 机遇。来自Shah博士正在进行的NIH R01资助的生物标本、临床和流行病学数据 背景研究为深入了解结核病传播提供了新的机会，包括 新冠肺炎大流行的社会接触模式是疾病传播的关键因素。语境研究 将作为本K24中提出的新研究的母体研究，该研究将：1)表征结核分枝杆菌基因组 使用长读排序和评估对传输网络的影响的关联性；以及2) 描述新冠肺炎大流行期间社会接触模式的变化，并评估其对结核病的影响 发病率。每个目标都旨在将具有经验和兴趣的学员整合到一起 在这些新兴的结核病传播科学领域的职业生涯。沙阿博士的研究和指导计划是 她与分枝杆菌领域的领先专家进行了长期、跨学科的合作 基因组学、药理学、免疫学、临床试验和数学建模。此外，杰出的 埃默里大学的培训资源、资助机会和研究基础设施将整合到Dr。 Shah的指导计划，以创造一个环境，使她的学员能够追求成功 在结核病、艾滋病毒和全球健康POR领域拥有独立、有影响力的职业生涯。

Dr. Shah is a physician-scientist with 15 years of experience leading patient-oriented research (POR) on diagnosis, treatment, and prevention of tuberculosis (TB) globally, including drug-resistant TB and TB/HIV co- infection. Her experience with U.S. and international public health programs, including the Centers for Disease Control & Prevention (CDC) where she trained and worked for a decade, provides a strong foundation for integrating research into policy and patient care. This K24 award will allow her to enhance and expand her successful mentorship in POR by providing vital protected time for training in advanced methods for studying TB transmission, and developing a structured mentoring program. Worldwide, TB is the leading cause of death among people living with HIV, with drug-resistant TB threatening decades of progress in TB and HIV control. Drug-resistant TB epidemics are driven primarily by person-to-person transmission of resistant strains, and innovative approaches to improve our understanding of TB transmission are urgently needed to guide effective interventions. Similarly, there is a need to train the next generation of scientists in multidisciplinary TB/HIV and global health POR. Dr. Shah’s robust research program supported by NIH, Gates Foundation, and CDC provides exciting training opportunities that attract trainees interested in multidisciplinary TB & HIV POR. She has a strong track record of mentorship of U.S. and international trainees in diverse areas of TB & HIV clinical research, and many of her mentees have pursued academic careers and K awards. In addition, through her role as Director of the Clinical Core for the NIH P30 Emory/Georgia TB Research Advancement Center and mentor on D43 and T32 programs, she is well placed to provide outstanding research and training opportunities. Biospecimens, clinical, and epidemiologic data from Dr. Shah’s ongoing NIH R01-funded CONTEXT study provide new opportunities for insights into TB transmission, including the impact of the COVID-19 pandemic on social contact patterns that are a key factor in disease spread. The CONTEXT study will serve as the parent study for the new research proposed in this K24 that will: 1) characterize Mtb genomic relatedness using long-read sequencing and evaluate the impact on transmission networks; and 2) characterize changes in social contact patterns during the COVID-19 pandemic and estimate the impact on TB incidence. Each aim is designed to integrate mentees who have experience and interest in growing their careers in these emerging areas of TB transmission science. Dr. Shah’s research and mentoring program is facilitated by her long-standing, cross-disciplinary collaborations with leading experts in mycobacterial genomics, pharmacology, immunology, clinical trials, and mathematical modeling. In addition, the outstanding training resources, funding opportunities, and research infrastructure at Emory will be integrated into Dr. Shah’s mentoring program to create an environment that enables the success of her trainees to pursue independent, impactful careers in TB, HIV, and global health POR.