Mentoring Multidisciplinary Patient-Oriented Research in TB, HIV, and Global Health

指导结核病、艾滋病毒和全球健康领域的多学科、以患者为导向的研究

• 批准号: 10619230
• 负责人: Nippie Sarita Shah
• 金额: $ 19.53万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-23 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619230
• 关键词: Affect; Area; Base Pairing; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Data; Clinical Research; Clinical Trials; Clonal Expansion; Collaborations; Communicable Diseases; Communities; Data; Diagnosis; Disease; Drug resistance in tuberculosis; Ensure; Environment; Epidemic; Epidemiologist; Epidemiology; Extreme drug resistant tuberculosis; Foundations; Funding; Funding Opportunities; Genomics; Goals; HIV; HIV/TB; Health; Health Policy; Household; Immunology; Incidence; Individual; Interdisciplinary Study; International; K-Series Research Career Programs; Knowledge; Lead; Link; Location; M. tuberculosis genome; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular Epidemiology; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mycobacterium tuberculosis; Parents; Participant; Patient Care; Pattern; Persons; Pharmacology; Physicians; Policies; Prevention; Public Health; Research; Research Infrastructure; Resources; Rifampicin resistance; Role; Science; Scientific Advances and Accomplishments; Scientist; Social Mobility; South Africa; Specimen; Structure; Time; Training; Treatment outcome; Tuberculosis; United States National Institutes of Health; Universities; Work; career; career development; co-infection; community setting; design; detection limit; effective intervention; epidemiologic data; epidemiology study; experience; genome sequencing; global health; improved; innovation; insight; interest; mathematical model; multidisciplinary; mycobacterial; next generation; novel; novel diagnostics; novel therapeutics; patient oriented; patient oriented research; prevent; programs; research study; resistant strain; skills; social; social contact; success; training opportunity; transmission process; whole genome

Dr. Shah is a physician-scientist with 15 years of experience leading patient-oriented research (POR) on diagnosis, treatment, and prevention of tuberculosis (TB) globally, including drug-resistant TB and TB/HIV co- infection. Her experience with U.S. and international public health programs, including the Centers for Disease Control & Prevention (CDC) where she trained and worked for a decade, provides a strong foundation for integrating research into policy and patient care. This K24 award will allow her to enhance and expand her successful mentorship in POR by providing vital protected time for training in advanced methods for studying TB transmission, and developing a structured mentoring program. Worldwide, TB is the leading cause of death among people living with HIV, with drug-resistant TB threatening decades of progress in TB and HIV control. Drug-resistant TB epidemics are driven primarily by person-to-person transmission of resistant strains, and innovative approaches to improve our understanding of TB transmission are urgently needed to guide effective interventions. Similarly, there is a need to train the next generation of scientists in multidisciplinary TB/HIV and global health POR. Dr. Shah’s robust research program supported by NIH, Gates Foundation, and CDC provides exciting training opportunities that attract trainees interested in multidisciplinary TB & HIV POR. She has a strong track record of mentorship of U.S. and international trainees in diverse areas of TB & HIV clinical research, and many of her mentees have pursued academic careers and K awards. In addition, through her role as Director of the Clinical Core for the NIH P30 Emory/Georgia TB Research Advancement Center and mentor on D43 and T32 programs, she is well placed to provide outstanding research and training opportunities. Biospecimens, clinical, and epidemiologic data from Dr. Shah’s ongoing NIH R01-funded CONTEXT study provide new opportunities for insights into TB transmission, including the impact of the COVID-19 pandemic on social contact patterns that are a key factor in disease spread. The CONTEXT study will serve as the parent study for the new research proposed in this K24 that will: 1) characterize Mtb genomic relatedness using long-read sequencing and evaluate the impact on transmission networks; and 2) characterize changes in social contact patterns during the COVID-19 pandemic and estimate the impact on TB incidence. Each aim is designed to integrate mentees who have experience and interest in growing their careers in these emerging areas of TB transmission science. Dr. Shah’s research and mentoring program is facilitated by her long-standing, cross-disciplinary collaborations with leading experts in mycobacterial genomics, pharmacology, immunology, clinical trials, and mathematical modeling. In addition, the outstanding training resources, funding opportunities, and research infrastructure at Emory will be integrated into Dr. Shah’s mentoring program to create an environment that enables the success of her trainees to pursue independent, impactful careers in TB, HIV, and global health POR.

Shah博士是一名拥有15年经验的医师兼科学家，他领导了以患者为导向的研究（POR）