Integrative Training in the Pharmacological Sciences

描述（由申请人提供）：这个综合药理学培训计划（IPSTP）是为在药理学领域进行论文研究项目的二年级和三年级博士生设计的。学员和培训教师（36人）来自4个博士专业（生物化学与分子生物学、细胞与分子生物学、神经科学和药理学与毒理学）。IPSTP的独特重点是体内药理学方法和概念的培训。IPSTP培训教师的研究专长集中在三个重叠的主题：1)细胞生长，分化，损伤和修复；2)细胞内和细胞间信号传导；3)综合药理学和生理学。申请资金支持1年级的3名学生和2-5年级的6名学生（每个学生获得2年的支持）。培训项目将由一名项目主管（Galligan）和一个执行委员会管理，执行委员会由每个项目的一名代表和一名学员组成。该计划还由参与博士项目的主席或主任组成的内部咨询委员会指导。培训计划有7个核心要素：1)一个研究项目，其结果导致博士论文和药理学知识的贡献；2)为期两周的药理学方法短期课程（“新兵训练营”）；3)药理学和生物统计学三门课程；4)每周一次的沟通技巧和专业发展研讨会（在两年的项目支持期间，以及支持结束后的两年，学员都需要参加）；5)有受指导的教学经历；6)参加定量系统生物学研讨会；7)参加年度项目静修。学员还需要参加研究生院提供的负责任的研究行为（RCR）系列讲习班和项目具体的RCR活动。学员可获得的补充活动包括：1)参与在线课程开发和交付的机会；2)参加校内in Vivo药理学机构的实习（4-6周），该机构作为合同研究机构。学员将接触到与合同工作相关的问题（良好实验室规范协议、预算和合同开发、数据安全、按时交付成果）。IPSTP制定了一项全面计划，招收高素质的学生，包括代表性不足的少数民族学生。IPSTP将为受训者提供优秀的研究和专业培训，并为他们在学术界、工业界和政府从事研究工作做好准备。

DESCRIPTION (provided by applicant): This Integrative Pharmacological Sciences Training Program (IPSTP) is designed for 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty (n=36) are drawn from 4 Ph.D. programs (Biochemistry & Molecular Biology, Cell & Molecular Biology, Neuroscience and Pharmacology & Toxicology). The unique focus of the IPSTP is training with in vivo pharmacological approaches and concepts. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) cell growth, differentiation, injury and repair; 2) intra and intercellular signaling and, 3) integrative pharmacology and physiology. Funds are requested to support 3 students in year 1 and 6 students in years 2-5 (each student receives 2 years of support). The training program will be administered by a Program Director (Galligan) and an Executive Committee composed of a representative of each program and a student trainee. The program is also guided by an Internal Advisory Committee composed of the Chairs or Directors of the participating Ph.D. programs. There are 7 core elements to the training plan: 1) a research project whose results lead to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) a two week short course in pharmacological methods ("Boot camp"); 3) a three course curriculum in pharmacology and biostatistics; 4) a weekly Communications Skills and Professional Development Workshop (trainee participation is required during the two years of program support and for two years after support has ended); 5) a mentored teaching experience; 6) participation in a quantitative systems biology workshop and; 7) participation in an annual program retreat. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program specific RCR activities. Supplemental activities that are available to trainees include: 1) opportunities to participate in development and delivery of online classes; 2) participation in an internship (4-6 week) in an on-campus In Vivo Pharmacology facility which functions as a contract research organization. Trainees would be exposed to issues related to contract work (Good Laboratory Practice protocols, budget and contract development, data security, delivering outcomes on schedule). The IPSTP has developed a comprehensive plan to recruit highly qualified students including under-represented minority students. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government.