Integrative Training in the Pharmacological Sciences

描述(由申请者提供)：本综合药理学培训计划(IPSTP)是为攻读药理学学位论文研究项目的二年级和三年级博士生设计的。实习生和培训教师(n=36)来自4个博士专业(生物化学与分子生物学、细胞与分子生物学、神经科学和药理学与毒理学)。IPSTP的独特重点是用体内药理学方法和概念进行培训。IPSTP培训人员的研究专长集中在三个相互重叠的主题中：1)细胞生长、分化、损伤和修复；2)细胞内和细胞间信号；3)综合药理学和生理学。申请资助一年级3名学生和2-5年级6名学生(每个学生获得两年资助)。培训计划将由一名计划主任(加里根)和一个执行委员会管理，执行委员会由每个计划的一名代表和一名受训学生组成。该计划还由一个由参与博士计划的主席或主任组成的内部咨询委员会指导。培训计划有7个核心要素：1)研究项目，其结果导致博士论文和对药理学知识的贡献；2)两周的药理学方法短期课程(“训练营”)；3)药理学和生物统计学的三门课程；4)每周一次的沟通技能和专业发展研讨会(受训者需要在两年的计划支持期间和支持结束后的两年内参加)；5)指导教学经验；6)参加定量系统生物学研讨会和7)参加年度计划务虚会。学员还被要求参加由研究生院提供的负责任的研究行为(RCR)研讨会系列和项目特定的RCR活动。学员可参加的补充活动包括：1)参与开发和提供在线课程的机会；2)参加Vivo药理机构作为合同研究机构运作的校园内实习(4-6周)。受训人员将接触到与合同工作有关的问题(良好的实验室操作规程、预算和合同制定、数据安全、按时交付成果)。IPSTP制定了一项全面计划，招收高素质学生，包括代表性不足的少数族裔学生。IPSTP将为学员提供出色的研究和专业培训，并为他们在学术界、工业界和政府的研究生涯做好准备。 公共卫生相关性：拟议的培训计划将为学生在药理学研究中的领导职业生涯做好准备。完成这一项目的学员将为我们了解人类疾病的原因和治疗做出重要贡献。

DESCRIPTION (provided by applicant): This Integrative Pharmacological Sciences Training Program (IPSTP) is designed for 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty (n=36) are drawn from 4 Ph.D. programs (Biochemistry & Molecular Biology, Cell & Molecular Biology, Neuroscience and Pharmacology & Toxicology). The unique focus of the IPSTP is training with in vivo pharmacological approaches and concepts. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) cell growth, differentiation, injury and repair; 2) intra and intercellular signaling and, 3) integrative pharmacology and physiology. Funds are requested to support 3 students in year 1 and 6 students in years 2-5 (each student receives 2 years of support). The training program will be administered by a Program Director (Galligan) and an Executive Committee composed of a representative of each program and a student trainee. The program is also guided by an Internal Advisory Committee composed of the Chairs or Directors of the participating Ph.D. programs. There are 7 core elements to the training plan: 1) a research project whose results lead to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) a two week short course in pharmacological methods ("Boot camp"); 3) a three course curriculum in pharmacology and biostatistics; 4) a weekly Communications Skills and Professional Development Workshop (trainee participation is required during the two years of program support and for two years after support has ended); 5) a mentored teaching experience; 6) participation in a quantitative systems biology workshop and; 7) participation in an annual program retreat. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program specific RCR activities. Supplemental activities that are available to trainees include: 1) opportunities to participate in development and delivery of online classes; 2) participation in an internship (4-6 week) in an on-campus In Vivo Pharmacology facility which functions as a contract research organization. Trainees would be exposed to issues related to contract work (Good Laboratory Practice protocols, budget and contract development, data security, delivering outcomes on schedule). The IPSTP has developed a comprehensive plan to recruit highly qualified students including under-represented minority students. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government. PUBLIC HEALTH RELEVANCE: The proposed training program will prepare students for leadership careers in pharmacological research. The trainees completing this program will make important contributions to our understanding of the causes and treatments of human illness.