Novel Innate Immune Adjuvant for Avian Influenza and West Nile Virus Vaccines
Novel Innate Immune Adjuvant for Avian Influenza and West Nile Virus Vaccines
批准号:
8751849
负责人:
MICHAEL GALE
金额:
$677.01万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-30 至 2016-09-29
关键词:
AdjuvantAdjuvant StudyAntigensAvian InfluenzaAvian Influenza A VirusBird Flu vaccineDevelopmentDoseDrug FormulationsEmerging Communicable DiseasesFDA approvedFerretsFlavivirusGenesHumanImmune responseImmunologic AdjuvantsInfectionInfluenza A Virus, H5N1 SubtypeInvestigational DrugsInvestigational New Drug ApplicationLeadLicensingLicensureMusNational Institute of Allergy and Infectious DiseaseNatural ImmunityPathway interactionsPharmaceutical ChemistryProgram DevelopmentStagingSystemToxicologyTretinoinVaccine AdjuvantVaccinesVirus DiseasesWest Nile virushuman IRF3 proteininfluenza virus vaccineinterferon regulatory factor-3novelpathogenprogramsresponsesmall moleculetranscription factor
中文摘要
NIAID/DAIT佐剂开发计划支持通过免疫学表征研究和先导化合物优化开发新的候选疫苗佐剂,直至并包括IND使能研究,所有这些都是为了获得人用许可。佐剂将与目前许可的或新的研究疫苗一起研究,以防止NIAID新发和再发传染病病原体的感染。
英文摘要
The NIAID/DAIT Adjuvant Development Program supports the development of new candidate vaccine adjuvants through immunological characterization studies and lead compound optimization, up to and including IND-enabling studies, all towards licensure for human use. Adjuvants will be studied with currently licensed or new investigational vaccines to protect against infection by NIAID emerging and re-emerging infectious disease pathogens.
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会议论文
Nonhuman Primate (NHP) Core Functional Genomics Laboratory for AIDS Vaccine Research and Development
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项目类别:
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依托单位:
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批准号:9543270
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财政年份:2017
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依托单位:
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