Nonhuman Primate (NHP) Core Functional Genomics Laboratory for AIDS Vaccine Research and Development

非人类灵长类动物 (NHP) 艾滋病疫苗研发核心功能基因组实验室

• 批准号: 10880212
• 负责人: MICHAEL GALE
• 金额: $ 260.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10880212
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Algorithms; Bioinformatics; Biological Assay; Cellular Immunology; Contractor; Contracts; Data; Enrollment; Ensure; Genomic approach; Genomics; Immune response; Immunologic Tests; Immunologics; Immunology; Infection prevention; Innate Immune Response; Laboratories; Methods; Modeling; National Institute of Allergy and Infectious Disease; Protocols documentation; RNA; Research Personnel; Sampling; Services; Site; Standardization; Testing; Vaccine Research; Vaccines; Viral; Virus; Virus Replication; adaptive immune response; biocomputing; design; functional genomics; genetic signature; improved; nonhuman primate; pre-clinical; response; tool; transcriptomics; vaccine development; vaccine efficacy; vaccine evaluation

Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. NIAID provides immunological and virological support for NHP studies conducted at NIAID's Simian Vaccine Evaluation Unit (SVEU) contract sites and by Division of AIDS (DAIDS)-supported vaccine researchers through four existing NHP Core Laboratories (NHP Core Labs): the Functional Genomics Lab, the Humoral Immunology Lab, the Cellular Immunology Lab, and the Viral Lab. The NHP Core Functional Genomics Laboratory has the objective of ensuring standardization and comparability of functional genomics services and assays conducted for the SVEU and DAIDS-supported preclinical NHP studies. Importantly, the ultimate aim is to apply and refine high throughput functional genomics approaches in NHPs to more effectively evaluate vaccine-induced adaptive and innate immune responses and vaccine efficacy in challenge/protection studies and identify responses (e.g., transcriptomic "signatures") that predict vaccine efficacy.

非人灵长类动物(NHP)模型提供了测试各种候选艾滋病疫苗的机会，优化了它们诱导免疫反应的能力，并测试了它们在病毒攻击后预防感染或控制病毒复制的能力。NIAID通过以下四个现有的NHP核心实验室(NHP核心实验室)为NHP研究提供免疫学和病毒学支持：功能基因组学实验室、体液免疫学实验室、细胞免疫学实验室和病毒实验室。NHP核心功能基因组实验室的目标是确保为SVEU和DAIDS支持的临床前NHP研究进行的功能基因组服务和分析的标准化和可比性。重要的是，最终目标是将高通量功能基因组学方法应用和改进到NHP中，以便在挑战/保护研究中更有效地评估疫苗诱导的适应性和先天免疫反应以及疫苗效力，并识别预测疫苗效力的应答(例如，转录“签名”)。