Fifth World Congress of Leishmaniasis 2013

2013 年第五届世界利什曼病大会

• 批准号: 8529171
• 负责人: LYNN SOONG
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-19 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529171
• 关键词: Address; Area; Basic Science; Brazil; Cells; Clinical; Clinical Sciences; Collaborations; Communicable Diseases; Congresses; Country; Dendritic Cells; Disabled Persons; Disease; Drug resistance; Ensure; Epidemiology; Faculty; Fees; Functional disorder; Funding; Goals; Human; Immunology; Infection; Institution; International; Lead; Leishmania; Leishmaniasis; Life; Minority; Molecular Biology; Natural Immunity; Parasites; Participant; Pharmaceutical Preparations; Public Health; Reporting; Request for Applications; Research; Research Personnel; Resources; Risk; Sand Flies; Site; Study models; Systems Biology; Therapeutic; Toxic effect; Training; Training and Education; Translational Research; Travel; Vaccines; Vacuole; Visit; Woman; Work; adaptive immunity; base; cost; drug development; global health; graduate student; macrophage; meetings; member; neglect; neutrophil; public health relevance; success; symposium; vaccine development; vector

DESCRIPTION (provided by applicant): This application requests support for trainees and junior faculty to attend the 5th World Congress of Leishmania and Leishmaniasis (WL5) to be held in Brazil in May 2013. Leishmania are protozoan parasites that infect neutrophils, dendritic cells, and macrophages. The active replication and long-term persistence of parasites within specialized vacuoles of macrophages and dendritic cells can lead to dysfunction of host innate and adaptive immunity. Leishmania parasites are transmitted to humans by sand flies and are widely distributed in about 90 tropical and subtropical countries, including certain parts of the U.S. They pose a major public health problem and a risk for millions of people living in endemic areas and entering those areas. The epidemiology of leishmaniasis is extremely diverse, and 20 species of the Leishmania genus are known to be pathogenic for humans. The available anti-Leishmania drugs are far from satisfactory due to high costs, toxicity, or drug resistance. Leishmaniasis is one of the world's principal neglected diseases, for which no effective vaccines are available for any form of the disease. To address these challenges, WL congresses have been held every four years in an endemic country since 1997, and they remain the only international meetings devoted exclusively to Leishmania and leishmaniasis. The primary goal of WL5 is to provide a platform by which investigators working in basic sciences, as well as field-based and translational research have a chance to interact directly. The purpose of this R15 application is to provide travel funds for graduate students, postdoctoral trainees, and junior faculty from the U.S. and other countries to attend WL5. Efforts will be made to provide support for women, minorities, and persons with disabilities and financial limitations. The success and impact of WL5 are ensured by local organizing committees and an International Scientific Committee. This congress and its training opportunities will have a significant impact on the control of infectious diseases and the improvement of global health.

描述（由申请人提供）：本申请要求支持学员和初级教员参加2013年5月在巴西举行的第五届利什曼原虫和利什曼病世界大会（WL5）。利什曼原虫是感染中性粒细胞、树突状细胞和巨噬细胞的原生动物寄生虫。寄生虫在巨噬细胞和树突状细胞的特殊液泡内的主动复制和长期存在可导致宿主先天和适应性免疫功能障碍。利什曼原虫通过沙蝇传播给人类，广泛分布在大约90个热带和亚热带国家，包括美国的某些地区。它们构成了一个重大的公共卫生问题，对生活在流行地区并进入这些地区的数百万人构成了威胁。利什曼病的流行病学极为多样化，已知有20种利什曼属对人类具有致病性。现有的抗利什曼原虫药物由于成本高、毒性大或耐药，远不能令人满意。利什曼病是世界上主要被忽视的疾病之一，没有针对任何形式该病的有效疫苗。为了应对这些挑战，自1997年以来，世卫组织大会每四年在一个流行国家举行一次，它们仍然是专门讨论利什曼原虫和利什曼病的唯一国际会议。WL5的主要目标是提供一个平台，让从事基础科学、实地研究和转化研究的研究人员有机会直接互动。本次R15申请的目的是为研究生、博士后培训生和大三学生提供旅行资金