A Situational Examination of Neurocognition and Affect with Simultaneous Cannabis

同时大麻的神经认知和影响的情境检查

• 批准号: 8484807
• 负责人: Randi Melissa Schuster
• 金额: $ 4.22万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2014-07-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484807
• 关键词: Acute; Address; Affect; Affective; Alcohol or Other Drugs use; Area; Behavioral; Cannabis; Cannabis Smoking; Cigarette; Cognition; Cognitive; Data; Data Analyses; Data Collection; Dependence; Development; Drug Combinations; Emotional; Enrollment; Event; Faculty; Frequencies; Goals; Health; Intervention; Intoxication; Investigation; Knowledge; Lead; Link; Longevity; Measures; Mentorship; Methodology; Methods; Motivation; Neurocognition; Neurocognitive; Neuropsychology; Outcome; Participant; Performance; Positioning Attribute; Prevalence; Prevention; Public Health; Reinforcing Factor; Reporting; Research; Research Design; Robin bird; Sampling; Short-Term Memory; Smoker; Smoking; Staging; Structure; Symptoms; Techniques; Time; Tobacco; Tobacco use; Training; Work; addiction; career; cigarette smoking; design; experience; improved; meetings; skills; smoking cessation; social; young adult

DESCRIPTION (provided by applicant): The goal of the proposed training plan is to further develop the applicant's knowledge and research skills in the areas of substance use and neuropsychology and to integrate this with an understanding of ecological momentary assessment (EMA) and data analysis. The ultimate goal of the proposal is to conduct a dissertation project that will deepen the applicant's knowledge of research design and analytic issues addressing the topic of cognitive and affective situational factors surrounding cannabis and tobacco use and the field's knowledge of the momentary factors that contribute to conjoint cannabis and tobacco use among young adults. Given the skills that will be developed and the knowledge that will be gained, this project is a necessary step in achieving the applicant's career goal to pursue a faculty position in an academic setting where independent investigations can be conducted. The training plan proposed includes structured course work, regular sponsor meetings, experience with EMA data collection and analysis, and professional development activities. The proposed research furthers this training plan by examining the conjoint effects of simultaneous cannabis and tobacco use on neurocognitive, affective and behavioral outcomes in young adult tobacco users. The motivation for examining this particular drug combination comes from the increasing number of young people reporting combined use of cannabis and tobacco, the health consequences associated with conjoint use (e.g., greater dependence symptoms, fewer successful quit attempts), and the limited number of investigations examining the mechanisms that maintain simultaneous use. Given that young adults are highly influenced by contextual variables, EMA techniques are an optimal method for assessing the potential neurocognitive and affective factors that reinforce conjoint use. The specific aims of this study are: 1) to examine the effects of simultaneous use of cannabis and tobacco on momentary levels of neurocognitive functioning, namely changes in working memory and to compare these effects to the effects of cannabis and tobacco alone; 2) to examine the effects of simultaneous use on momentary changes in affect and subjective cannabis intoxication and to compare these effects to the effects of cannabis and tobacco alone; and 3) to examine the link between momentary changes in neurocognition, affect and subjective intoxication on behavioral outcomes (e.g., dependence and problematic use). Data will be collected from 325 young adults currently enrolled in a large, ongoing longitudinal investigation of the social and emotional contexts of young adult tobacco use. Mentorship for this project will be provided by experts in the areas of tobacco use and EMA methodology (Dr. Robin Mermelstein), cannabis use and the neuropsychology of addiction (Dr. Raul Gonzalez), and hierarchical longitudinal data analysis (Dr. Robin Mermelstein and Dr. Donald Hedeker). This area of research is in its nascent stages, and this study will be one of the first to examine conjoint effects of cannabis and tobacco as well as to integrate neurocognitive and EMA measures to the study of this understudied phenomenon. Not only will the proposed plan be instrumental in propelling the applicant's career forward, but also promises to yield results that will be directly applicable to the development of prevention and cessation efforts for young adult tobacco users who also use cannabis.

描述（由申请人提供）：拟议的培训计划的目的是进一步发展申请人在物质使用和神经心理学领域的知识和研究技能，并将其与对生态瞬时评估（EMA）和数据分析的了解相结合。该提案的最终目的是开展论文项目，该项目将加深申请人对研究设计和分析问题的了解，以解决有关大麻和烟草使用的认知和情感情境因素的话题，以及该领域对年轻人使用的瞬时因素的了解。鉴于将要发展的技能和将获得的知识，该项目是实现申请人职业目标的必要步骤，即在可以进行独立调查的学术环境中攻读教职员工。拟议的培训计划包括结构化课程工作，定期赞助者会议，EMA数据收集和分析的经验以及专业发展活动。拟议的研究通过研究年轻成人烟草使用者的神经认知，情感和行为结果的同时大麻和烟草使用对神经认知，情感和行为成果的联合影响，从而进一步加强了这一培训计划。检查这种特殊药物组合的动机来自报告大麻和烟草使用综合使用的年轻人，与联合使用相关的健康后果（例如，更大的依赖性症状，成功的戒烟尝试更少）以及研究的研究数量有限，研究了维持同时使用的机制。鉴于年轻人受到上下文变量的影响很大，EMA技术是评估增强联合使用的潜在神经认知和情感因素的最佳方法。这项研究的具体目的是：1）检查大麻和烟草同时使用对神经认知功能的瞬时水平的影响，即工作记忆的变化，并将这些影响与单独的大麻和烟草的影响进行比较； 2）检查同时使用对情感和主观大麻中毒的瞬时变化的影响，并将这些影响与仅大麻和烟草的影响进行比较； 3）检查神经认知的瞬时变化，对行为结果的影响和主观中毒（例如依赖性和有问题的使用）之间的联系。数据将从目前正在参加大规模的，正在进行的纵向调查的年轻人中收集数据，对年轻成人烟草使用的社会和情感环境。该项目的指导将由烟草使用和EMA方法论（Robin Mermelstein博士），大麻使用和成瘾神经心理学（Raul Gonzalez博士）和等级纵向数据分析（Robin Mermelstein和Donald Hedeker博士）提供指导。该研究领域处于新生的阶段，这项研究将是最早检查大麻和烟草的联合效应的研究之一，以及将神经认知和EMA衡量标准与这种被忽视的现象的研究相结合。拟议的计划不仅有助于推动申请人的职业发展，而且还有望产生结果，这些结果将直接适用于为也使用大麻的年轻成人烟草用户开发预防和停止工作。