A Situational Examination of Neurocognition and Affect with Simultaneous Cannabis

同时大麻的神经认知和影响的情境检查

• 批准号: 8202062
• 负责人: Randi Melissa Schuster
• 金额: $ 4.18万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-05 至 2014-07-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202062
• 关键词: Acute; Address; Affect; Affective; Alcohol or Other Drugs use; Area; Behavioral; Cannabis; Cannabis Smoking; Cigarette; Cognition; Cognitive; Data; Data Analyses; Data Collection; Dependence; Development; Drug Combinations; Emotional; Enrollment; Event; Faculty; Frequencies; Goals; Health; Intervention; Intoxication; Investigation; Knowledge; Lead; Link; Longevity; Measures; Mentorship; Methodology; Methods; Motivation; Neurocognition; Neurocognitive; Neuropsychology; Outcome; Participant; Performance; Positioning Attribute; Prevalence; Prevention; Public Health; Reinforcing Factor; Reporting; Research; Research Design; Robin bird; Sampling; Short-Term Memory; Smoker; Smoking; Staging; Structure; Symptoms; Techniques; Time; Tobacco; Tobacco use; Training; Work; addiction; career; cigarette smoking; design; experience; improved; meetings; skills; smoking cessation; social; young adult

DESCRIPTION (provided by applicant): The goal of the proposed training plan is to further develop the applicant's knowledge and research skills in the areas of substance use and neuropsychology and to integrate this with an understanding of ecological momentary assessment (EMA) and data analysis. The ultimate goal of the proposal is to conduct a dissertation project that will deepen the applicant's knowledge of research design and analytic issues addressing the topic of cognitive and affective situational factors surrounding cannabis and tobacco use and the field's knowledge of the momentary factors that contribute to conjoint cannabis and tobacco use among young adults. Given the skills that will be developed and the knowledge that will be gained, this project is a necessary step in achieving the applicant's career goal to pursue a faculty position in an academic setting where independent investigations can be conducted. The training plan proposed includes structured course work, regular sponsor meetings, experience with EMA data collection and analysis, and professional development activities. The proposed research furthers this training plan by examining the conjoint effects of simultaneous cannabis and tobacco use on neurocognitive, affective and behavioral outcomes in young adult tobacco users. The motivation for examining this particular drug combination comes from the increasing number of young people reporting combined use of cannabis and tobacco, the health consequences associated with conjoint use (e.g., greater dependence symptoms, fewer successful quit attempts), and the limited number of investigations examining the mechanisms that maintain simultaneous use. Given that young adults are highly influenced by contextual variables, EMA techniques are an optimal method for assessing the potential neurocognitive and affective factors that reinforce conjoint use. The specific aims of this study are: 1) to examine the effects of simultaneous use of cannabis and tobacco on momentary levels of neurocognitive functioning, namely changes in working memory and to compare these effects to the effects of cannabis and tobacco alone; 2) to examine the effects of simultaneous use on momentary changes in affect and subjective cannabis intoxication and to compare these effects to the effects of cannabis and tobacco alone; and 3) to examine the link between momentary changes in neurocognition, affect and subjective intoxication on behavioral outcomes (e.g., dependence and problematic use). Data will be collected from 325 young adults currently enrolled in a large, ongoing longitudinal investigation of the social and emotional contexts of young adult tobacco use. Mentorship for this project will be provided by experts in the areas of tobacco use and EMA methodology (Dr. Robin Mermelstein), cannabis use and the neuropsychology of addiction (Dr. Raul Gonzalez), and hierarchical longitudinal data analysis (Dr. Robin Mermelstein and Dr. Donald Hedeker). This area of research is in its nascent stages, and this study will be one of the first to examine conjoint effects of cannabis and tobacco as well as to integrate neurocognitive and EMA measures to the study of this understudied phenomenon. Not only will the proposed plan be instrumental in propelling the applicant's career forward, but also promises to yield results that will be directly applicable to the development of prevention and cessation efforts for young adult tobacco users who also use cannabis. PUBLIC HEALTH RELEVANCE: Tobacco use continues to be a major public health problem among young adults. A large percentage of young adult tobacco users also engage in simultaneous cannabis use, both of which are linked with a host of negative health consequences. This project will serve to delineate the mechanisms that reinforce this conjoint use. A better understanding of the situational correlates and consequences of simultaneous cannabis and tobacco use will inform the creation of more targeted prevention and cessation efforts for the young adults who use both cannabis and tobacco.

描述（由申请人提供）：拟议培训计划的目标是进一步发展申请人在物质使用和神经心理学领域的知识和研究技能，并将其与对生态瞬时评估（EMA）和数据分析的理解相结合。该提案的最终目标是开展一个论文项目，该项目将加深申请人对研究设计和分析问题的了解，解决围绕大麻和烟草使用的认知和情感情境因素的主题，以及该领域对导致年轻人联合使用大麻和烟草的瞬间因素的了解。考虑到将发展的技能和将获得的知识，该项目是实现申请人职业目标的必要步骤，即在可以进行独立调查的学术环境中追求教师职位。建议的培训计划包括结构化的课程作业，定期的赞助商会议，EMA数据收集和分析的经验，以及专业发展活动。拟议的研究通过检查同时使用大麻和烟草对年轻成年烟草使用者的神经认知、情感和行为结果的共同影响，进一步推进了这一培训计划。审查这种特殊药物组合的动机是，越来越多的年轻人报告同时使用大麻和烟草，与联合使用有关的健康后果（例如，依赖症状加重，成功戒烟的尝试较少），以及审查维持同时使用的机制的调查数量有限。考虑到年轻人受到环境变量的高度影响，EMA技术是评估潜在的神经认知和情感因素的最佳方法，可以加强联合使用。本研究的具体目的是：1)研究同时使用大麻和烟草对神经认知功能瞬间水平的影响，即工作记忆的变化，并将这些影响与大麻和烟草单独使用的影响进行比较；2)检查同时使用对情绪的瞬间变化和主观大麻中毒的影响，并将这些影响与大麻和烟草单独使用的影响进行比较；3)研究神经认知、情感和主观中毒对行为结果（如依赖和有问题的使用）的瞬间变化之间的联系。将从325名年轻人中收集数据，这些年轻人目前正在参加一项关于年轻人烟草使用的社会和情感背景的大型纵向调查。该项目将由烟草使用和EMA方法（Robin Mermelstein博士）、大麻使用和成瘾神经心理学（Raul Gonzalez博士）以及分层纵向数据分析（Robin Mermelstein博士和Donald Hedeker博士）等领域的专家提供指导。这一领域的研究还处于起步阶段，这项研究将是第一批研究大麻和烟草共同作用的研究之一，并将神经认知和EMA措施整合到这一研究不足的现象的研究中。拟议的计划不仅将有助于推动申请人的职业发展，而且还有望产生直接适用于为同时使用大麻的年轻成年烟草使用者开展预防和戒烟工作的结果。