HIV 慢性气道和肺泡疾病的分子机制-猫眼课题宝

HIV 慢性气道和肺泡疾病的分子机制

批准号：

8637535

负责人：

JEFFREY J ATKINSON

金额：

$59.87万

依托单位：

WASHINGTON UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-09-26 至 2018-07-31

来源：

https://reporter.nih.gov/project-details/8637535

关键词：

Adopted Age of Onset Alveolar Alveolar Macrophages Asthma Biological Assay Biological Markers Biology Bronchoalveolar Lavage CCR5 gene CD4 Positive T Lymphocytes CD8B1 gene CXCR4 gene Cell Separation Cells Chronic Chronic Obstructive Airway Disease Chronic lung disease Clinical Clinical Trials Unit Collection Disease Elastin Eligibility Determination Evaluation Flow Cytometry Future HIV HIV Infections HIV Seropositivity HIV-1 Highly Active Antiretroviral Therapy Immune Immunosuppression Incidence Individual Infection Infectious Lung Disorder Inflammatory Interferons Interleukin-13 Low Dose Radiation Lung Lung diseases Macrophage Activation Malignant neoplasm of lung Matrix Metalloproteinases Measures Mediating Molecular Obstructive Lung Diseases Outcome Outcome Measure Pathogenesis Pathology Pathway interactions Peptide Hydrolases Phenotype Physiology Population Prevalence Process Production Protease Inhibitor Protocols documentation Pulmonary Emphysema Recruitment Activity Research Resources Sampling Scanning Screening for cancer Smoker Smoking Sorting - Cell Movement Speed Stimulus Suggestion T-Lymphocyte T-Lymphocyte Subsets Techniques Therapeutic Therapy Clinical Trials Universities Virus Diseases Washington Work X-Ray Computed Tomography airway remodeling alveolar destruction base cell type clinical phenotype clinically relevant cohort cytokine macrophage neutrophil novel population based programs public health relevance research study response secondary infection small airways disease

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中文摘要

翻译

描述（由申请人提供）：慢性阻塞性肺疾病（COPD）的发生率是HIV感染者的两倍。更好地理解这种加速疾病发生率背后的炎症过程将有助于指导未来HIV相关COPD和一般COPD的治疗试验。我们以前的工作表明，使用一个单一的低辐射剂量的计算机断层扫描（CT）扫描，我们可以确定个人与不同的临床表现，他们的肺部疾病。在这个建议中，我们将研究HIV相关COPD的炎症细胞基础，旨在指导未来的治疗试验。

英文摘要

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) occurs at twice the rate in individuals with HIV as those without. Better understanding of the inflammatory process behind this accelerated disease rate will assist in guiding future therapeutic trials in both HIV-related COPD and COPD in general. Our previous work demonstrated that using a single low radiation dose computed tomography (CT) scan we can identify individuals with different clinical expression of their lung disease. In this proposal we ill examine the inflammatory cell underpinnings of HIV-related COPD with an aim at guiding future therapeutic trials.

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