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MOLECULAR MECHANISMS OF CHRONIC AIRWAY AND ALVEOLAR DISEASE IN HIV

HIV 慢性气道和肺泡疾病的分子机制

基本信息

批准号：
8743253
负责人：
JEFFREY J ATKINSON
金额：
$ 63.61万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-26 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8743253
关键词：
Adopted Age of Onset Alveolar Alveolar Macrophages Asthma Biological Assay Biological Markers Biology Bronchoalveolar Lavage CCR5 gene CD4 Positive T Lymphocytes CD8B1 gene CXCR4 gene Cell Separation Cells Chronic Chronic Obstructive Airway Disease Chronic lung disease Clinical Clinical Trials Unit Collection Disease Elastin Eligibility Determination Evaluation Flow Cytometry Future HIV HIV Infections HIV Seropositivity HIV-1 Highly Active Antiretroviral Therapy Immune Immunosuppression Incidence Individual Infection Infectious Lung Disorder Inflammatory Interferons Interleukin-13 Low Dose Radiation Lung Lung diseases Macrophage Activation Malignant neoplasm of lung Matrix Metalloproteinases Measures Mediating Molecular Obstructive Lung Diseases Outcome Outcome Measure Pathogenesis Pathology Pathway interactions Peptide Hydrolases Phenotype Physiology Population Prevalence Process Production Protease Inhibitor Protocols documentation Pulmonary Emphysema Recruitment Activity Research Resources Sampling Scanning Screening for cancer Smoker Smoking Sorting - Cell Movement Speed Stimulus Suggestion T-Lymphocyte T-Lymphocyte Subsets Techniques Therapeutic Therapy Clinical Trials Universities Virus Diseases Washington Work X-Ray Computed Tomography airway remodeling alveolar destruction base cell type clinical phenotype clinically relevant cohort cytokine macrophage neutrophil novel population based programs public health relevance research study response secondary infection small airways disease

项目摘要

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) occurs at twice the rate in individuals with HIV as those without. Better understanding of the inflammatory process behind this accelerated disease rate will assist in guiding future therapeutic trials in both HIV-related COPD and COPD in general. Our previous work demonstrated that using a single low radiation dose computed tomography (CT) scan we can identify individuals with different clinical expression of their lung disease. In this proposal we ill examine the inflammatory cell underpinnings of HIV-related COPD with an aim at guiding future therapeutic trials.

描述（由申请人提供）：艾滋病毒感染者的慢性阻塞性肺病（COPD）发病率是未感染者的两倍。更好地了解这种疾病发病率加速背后的炎症过程将有助于指导未来艾滋病毒相关慢性阻塞性肺病和一般慢性阻塞性肺病的治疗试验。我们之前的工作表明，使用单次低辐射剂量计算机断层扫描 (CT) 扫描，我们可以识别具有不同肺部疾病临床表现的个体。在本提案中，我们将检查 HIV 相关慢性阻塞性肺病的炎症细胞基础，旨在指导未来的治疗试验。