UCLA NEXT Collaboration Site

UCLA NEXT 合作网站

• 批准号: 8529638
• 负责人: BRUCE H DOBKIN
• 金额: $ 28.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529638
• 关键词: Address; Adult; Adverse event; Agreement; Blinded; California; Childhood; Cities; Clinic; Clinic Visits; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Commit; Communication; Communities; Community Outreach; Complex; Consent; Contracts Review; County; Data; Data Coordinating Center; Data Quality; Databases; Development; Disabled Persons; Disease; Drug Industry; Enrollment; Ethical Review; Ethnic Origin; Evidence based treatment; Faculty; Fostering; Foundations; Funding; Goals; Health; Healthcare Systems; Heterogeneity; Hospitals; Individual; Industry; Institutes; Institutional Review Boards; Intervention; Los Angeles; Measurement; Medical center; Minority; Monitor; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Neurosciences; Olives - dietary; Online Systems; Outcome; Outcome Assessment; Participant; Patient Monitoring; Patients; Performance; Phase; Phase II Clinical Trials; Population Heterogeneity; Practical trial; Private Practice; Protocols documentation; Publications; Race; Randomized Controlled Clinical Trials; Recruitment Activity; Recurrence; Rehabilitation Centers; Rehabilitation therapy; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Schedule; Scholarship; Site; Socioeconomic Status; Solutions; Sum; System; Testing; Therapeutic Intervention; Time; Training; Training Programs; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Visit; Woman; adjudicate; base; career; clinical research site; cost effective; design; electronic data; evidence base; experience; improved; lectures; medical schools; medical specialties; meetings; member; minority subjects; multi-site trial; nervous system disorder; outreach program; programs; response; skills; tool

DESCRIPTION (provided by applicant): The UCLA Neurology NEXT clinical site commits to the development and completion of phase 2 trials by the experienced two PD/PIs and the over 80 adult and pediatric clinicians of the UCLA Department of Neurology. This department has been the top recipient of NIH funding among neurology departments for the past 8 years and includes 19 disease-oriented clinical programs. Each of the 19 Program Directors commits to participation in NEXT trials and will use this opportunity to augment training opportunities for fellows and junior faculty. Department faculty members have been leaders in the design and management of clinical trials; programs participate in 40-50 trials yearly that enroll large numbers of participants from Los Angeles County's racially and ethnically diverse population. In 2004, the Department created a Center for NeuroTherapeutics with four clinic rooms to foster clinical trials. To further our ability to recruit and retain trial participants, we will intensify partnerships with the neurologists at the L.A. County's Harbor-UCLA and the Olive View-UCLA Medical Centers, the County's Rancho Los Amigos National Rehabilitation Center, the VA Greater Los Angeles Healthcare System, Cedars-Sinai Medical Center, and the UCLA and Cedars voluntary faculty in private practice. The combined faculty assesses over 200,000 new patients yearly. We will use Web-based communications with our sites and prospectively identify potential subjects for trials during clinic visits and faculty lectures in the community t give more women and minorities the opportunity to participate. We will utilize the community-outreach programs created by our NIH-funded Clinical Translational Science Institute to further our outstanding track record of enrolling minority subjects. UCLA has shown its institutional support by agreeing to a Central IRB and master contractual agreements. The PIs and faculty look forward to adding our expertise and collaborating with colleagues at other sites, as well as with the CCC and DCC, to rapidly implement and complete protocols, test new activity-monitoring and outcome-measurement tools, nest studies within protocols to improve recruitment and retention strategies, and train young clinical investigators.

描述（由申请人提供）：UCLA Neurology NEXT临床研究中心致力于由经验丰富的两名PD/PI和UCLA神经科的80多名成人和儿科临床医生开发和完成II期试验。在过去的8年里，该部门一直是美国国立卫生研究院资助神经科的最高接受者，包括19个以疾病为导向的临床项目。19个项目主任中的每一个都承诺参加NEXT试验，并将利用这个机会增加研究员和初级教师的培训机会。部门的教师一直在临床试验的设计和管理的领导者;程序参与40-50试验每年招收大量的参与者从洛杉矶县的种族和民族多样化的人口。2004年，该部门创建了一个神经治疗中心，有四个诊所，以促进临床试验。为了进一步提高我们招募和留住试验参与者的能力，我们将加强 和洛杉矶的神经科医生合作县的港口加州大学洛杉矶分校和橄榄视图加州大学洛杉矶分校医疗中心，县的兰乔洛杉矶之友国家康复中心，弗吉尼亚州大洛杉矶医疗保健系统，雪松西奈医疗中心，以及加州大学洛杉矶分校和雪松志愿教师在私人执业。合并后的教师每年评估超过20万名新患者。我们将使用基于网络的通信与我们的网站，并前瞻性地确定潜在的主题，在临床访问和教师讲座在社区t给更多的妇女和少数民族的机会参与试验。我们将利用我们的NIH资助的临床转化科学研究所创建的社区外展计划，以进一步促进我们在招收少数民族受试者方面的出色记录。加州大学洛杉矶分校通过同意中央机构审查委员会和主合同协议来表明其机构支持。PI和教师期待着增加我们的专业知识，并与其他网站的同事以及CCC和DCC合作，以快速实施和完成协议，测试新的活动监测和结果测量工具，在协议内嵌套研究，以改善招聘和保留策略，并培训年轻的临床研究人员。