UCLA NEXT Collaboration Site

描述(由申请人提供)：加州大学洛杉矶分校神经病学下一个临床站点致力于开发和完成由加州大学洛杉矶分校神经科有经验的两名PD/PI和80多名成人和儿科临床医生进行的第二阶段试验。在过去的8年里，这个部门一直是NIH神经科中最大的资金接受者，包括19个以疾病为导向的临床项目。19名项目主任中的每一位都承诺参与下一次试验，并将利用这次机会增加对研究员和初级教员的培训机会。该部门的教职员工一直是临床试验设计和管理的领导者；项目每年参与40-50项试验，这些试验招收了来自洛杉矶县种族和民族多样化人口的大量参与者。2004年，该部门成立了一个神经治疗中心，设有四个诊所，以促进临床试验。为了加强我们招募和留住试验参与者的能力，我们将加强 与洛杉矶县港湾-加州大学洛杉矶分校和橄榄园-加州大学洛杉矶分校的神经科医生、该县的牧场之友国家康复中心、退伍军人事务部大洛杉矶医疗系统、锡达斯-西奈医学中心以及加州大学洛杉矶分校和雪松志愿教师的私人执业合作伙伴关系。联合教职员工每年评估20多万名新患者。我们将在我们的网站上使用基于网络的交流，并在社区的诊所访问和教师讲座期间前瞻性地确定潜在的试验对象，让更多的妇女和少数族裔有机会参与。我们将利用由美国国立卫生研究院资助的临床转化科学研究所创建的社区外展计划，进一步推动我们在招收少数族裔科目方面的杰出记录。加州大学洛杉矶分校通过同意中央IRB和主合同协议来显示其机构支持。PIS和教职员工期待着增加我们的专业知识，并与其他地点的同事以及CCC和DCC合作，以快速实施和完成方案，测试新的活动监测和结果测量工具，在方案中嵌套研究以改进招募和保留策略，并培训年轻的临床研究人员。

DESCRIPTION (provided by applicant): The UCLA Neurology NEXT clinical site commits to the development and completion of phase 2 trials by the experienced two PD/PIs and the over 80 adult and pediatric clinicians of the UCLA Department of Neurology. This department has been the top recipient of NIH funding among neurology departments for the past 8 years and includes 19 disease-oriented clinical programs. Each of the 19 Program Directors commits to participation in NEXT trials and will use this opportunity to augment training opportunities for fellows and junior faculty. Department faculty members have been leaders in the design and management of clinical trials; programs participate in 40-50 trials yearly that enroll large numbers of participants from Los Angeles County's racially and ethnically diverse population. In 2004, the Department created a Center for NeuroTherapeutics with four clinic rooms to foster clinical trials. To further our ability to recruit and retain trial participants, we will intensify partnerships with the neurologists at the L.A. County's Harbor-UCLA and the Olive View-UCLA Medical Centers, the County's Rancho Los Amigos National Rehabilitation Center, the VA Greater Los Angeles Healthcare System, Cedars-Sinai Medical Center, and the UCLA and Cedars voluntary faculty in private practice. The combined faculty assesses over 200,000 new patients yearly. We will use Web-based communications with our sites and prospectively identify potential subjects for trials during clinic visits and faculty lectures in the community to give more women and minorities the opportunity to participate. We will utilize the community-outreach programs created by our NIH-funded Clinical Translational Science Institute to further our outstanding track record of enrolling minority subjects. UCLA has shown its institutional support by agreeing to a Central IRB and master contractual agreements. The PIs and faculty look forward to adding our expertise and collaborating with colleagues at other sites, as well as with the CCC and DCC, to rapidly implement and complete protocols, test new activity-monitoring and outcome-measurement tools, nest studies within protocols to improve recruitment and retention strategies, and train young clinical investigators.