Linking Biological and Social Pathways to Adolescent Health and Well-Being

将生物和社会途径与青少年健康和福祉联系起来

• 批准号: 8430135
• 负责人: Jodi Ford
• 金额: $ 25.52万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8430135
• 关键词: Adherence; Adolescent; Adolescent Risk Behavior; Adrenal Glands; African American; Alcohol or Other Drugs use; Behavioral; Biological; Biological Markers; Chronic; Chronic stress; Cohort Studies; Collection; Community Surveys; Computer Assisted; County; Crime; Data; Data Collection; Data Quality; Data Sources; Development; Discipline; Disease; Exposure to; Foundations; Funding; Future; Grant; Hair; Health; Health Benefit; Health behavior; Household and Family; Human Herpesvirus 4; Hydrocortisone; Hypothalamic structure; Impaired health; Individual; Interview; Lead; Length; Life; Life Cycle Stages; Link; Mails; Measurement; Measures; Mediating; Mental Health; Methodology; Neighborhoods; Neurosecretory Systems; Not Hispanic or Latino; Ohio; Outcome; Pathway interactions; Personal Satisfaction; Pituitary Gland; Population; Population Research; Population Study; Positioning Attribute; Protocols documentation; Psychosocial Factor; Psychosocial Stress; Research; Respondent; Retrieval; Risk; Risk Behaviors; Role; Saliva; Salivary; Sampling; Schools; Shapes; Social Impacts; Social Network; Stress; System; Techniques; Testing; Time; United States National Institutes of Health; Validity and Reliability; Variant; Victimization; Violence; abstracting; aged; cost effective; cost effectiveness; design; environmental stressor; health disparity; immune function; multilevel analysis; physical conditioning; prospective; psychosocial; public health relevance; racial and ethnic; research study; response; sample collection; social; socioeconomics; stressor; trait; viral DNA

DESCRIPTION (provided by applicant): Linking Biological and Social Pathways to Adolescent Health and Well-Being Abstract Research across disciplines provides strong evidence that exposure to chronic stress contributes to poor physical and mental health outcomes across the life course. Consequently, large-scale population studies have increasingly integrated the collection of biomarkers of hypothalamus-pituitary-adrenal (HPA) activity (e.g. cortisol) to investigate the extent to which the neuroendocrine pathway explicates the role of chronic stress in shaping poor health outcomes and racial/ethnic and socioeconomic health disparities. However, few population studies have collected cortisol biomarkers from adolescents and among those that have, significant methodological challenges ultimately hampered data quality. Therefore, the purpose of this R21 proposal is to field test the collection of non-invasive longitudinal cortisol samples from adolescents to explore the validity and reliability of nightly measures of salivary cortisol for 6 nights and one hair sample for cortisol. The findings will determine if the collection of these measures is feasible and informative in a population of adolescents across a spectrum of social risk for impaired health. This R21 proposal is unique in that we will leverage a subsample of adolescents participating in the first wave of a recently funded prospective cohort study - the Adolescent Health and Development in Context (AHDC) study (PI Browning; NIH 1R01DA032371-01 and the William T. Grant Foundation). The AHDC study will examine the impact of spatial and social exposures on the risk behavior, victimization and mental health outcomes of 4,000 adolescents aged 11-17 years in Franklin County, Ohio. The specific aims of this R21 proposal are: Aim 1: To field test the collection of non-invasive biomarkers of cortisol in adolescents via nightly salivary samples for 6 nights and one hair sample and Aim 2: To examine the relationships between the (a) cortisol biomarkers; (b) immune function biomarkers (EBV DNA) and (c) linked secondary data from the AHDC study of adolescent risk behavior, psychosocial stressors, and environmental stressors. Our analytic strategy will employ advanced multilevel modeling techniques designed to estimate the variability in cortisol levels between and within individuals and the behavioral, psychosocial and environmental stressors associated with this variability. The findings of this R21 proposal will inform the selection of a high-quality, feasible and cost-effective biomarker data collection protocol to determine the biological impact of social risk on adolescent health and behavior in the second wave of the AHDC study. In addition, these data will inform the design of future population research studies to reduce adolescent health risk and disparities, with potential health benefits over the life course.

摘要跨学科研究提供了强有力的证据，表明长期压力会导致整个生命过程中身体和心理健康状况不佳。因此，大规模人口研究越来越多地整合了下丘脑-垂体-肾上腺（HPA）活性生物标志物（如皮质醇）的收集，以调查神经内分泌途径在多大程度上解释慢性应激在形成不良健康结果和种族/民族和社会经济健康差异中的作用。然而，很少有人口研究从青少年中收集皮质醇生物标志物，在这些研究中，重大的方法挑战最终阻碍了数据质量。因此，本R21提案的目的是实地测试从青少年中收集的非侵入性纵向皮质醇样本，以探索6个晚上的唾液皮质醇夜间测量和一个头发样本的皮质醇的有效性和可靠性。调查结果将确定这些措施的收集在健康受损社会风险范围内的青少年人群中是否可行和提供信息。这项R21提案的独特之处在于，我们将利用青少年的子样本参与最近资助的前瞻性队列研究的第一波-青少年健康与发展（AHDC）研究（PI Browning； NIH 1R01DA032371-01和William T. Grant基金会）。AHDC研究将调查空间和社会暴露对俄亥俄州富兰克林县4000名11-17岁青少年的风险行为、受害和心理健康结果的影响。该R21提案的具体目的是：目的1：通过连续6晚的夜间唾液样本和一次头发样本，实地测试青少年皮质醇的非侵入性生物标志物的收集；目的2：检查(a)皮质醇生物标志物之间的关系；(b)免疫功能生物标志物（EBV DNA）和(c)来自AHDC青少年风险行为、社会心理压力源和环境压力源研究的相关次要数据。我们的分析策略将采用先进的多层次建模技术，旨在估计个体之间和个体内部皮质醇水平的可变性，以及与这种可变性相关的行为、社会心理和环境压力因素。这项R21提案的研究结果将为选择高质量、可行和具有成本效益的生物标志物数据收集方案提供信息，以确定第二波AHDC研究中社会风险对青少年健康和行为的生物学影响。此外，这些数据将为未来人口研究的设计提供信息，以减少青少年健康风险和差异，并在整个生命过程中带来潜在的健康益处。