UNC Center for Diabetes Translation Research to Reduce Health Disparities

目前，十分之一的美国成年人（约2400万人）患有2型糖尿病，预测表明，如果目前的趋势继续下去，到2050年，三分之一的人可能会受到影响。糖尿病和相关的心血管疾病、视网膜病、肾病和神经病的患病率在美洲原住民、非洲裔美国人和拉丁美洲人中的脆弱人群中更严重。循证医学临床护理指南为糖尿病患者的健康提供了路线图。然而，CDC报告说，50%-60%的糖尿病患者遵守护理指南。科学和实践之间的这种差距是糖尿病翻译研究中心减少健康差异的基本原理。该中心的使命是通过在北卡罗来纳州及其他地区推进转化科学，改善北卡罗来纳州及其他地区1型、2型或妊娠糖尿病或相关疾病患者的健康状况，从而对糖尿病及其并发症进行一级或二级预防。本研究的目标是：1）开发一套整合的核心和计划，合并和集中现有资源，将研究进展转化为临床和社区实践，减少糖尿病相关的健康差异，部分通过a）中心利用率，B）跟踪后续出版物和校外奖励，以及c）跟踪研究结果的主要结果作为潜在公共卫生改善的标志; 2）利用现有的NIDDK研究基础设施来增强中心的研究资源，包括NIDDK糖尿病中心，NC转化和临床科学研究所（CTSA），Sheps健康服务研究中心，Lineberger癌症中心，以及其他NIDDK资助的资源，如NORC健康应用营养交流，干预（CHAI）核心，以及相关的NIDDK资助的T32计划;和3）制定一个丰富的计划，以加强互动和促进与糖尿病研究人员或学员，和其他代表UNC-CH和UNC-P和其他联盟成员的糖尿病差异相关领域的研究人员的转化研究方法的科学交流。该中心准备实现其目标，这可能会导致糖尿病翻译科学的生产力提高，糖尿病患者的健康，并减少糖尿病患者之间的健康差距。

Currently 1 in 10 US adults (about 24 million people) has Type 2 diabetes, and projections suggest that 1 in 3 people may be affected in 2050 if current trends continue. The prevalence of diabetes and associated cardiovascular disease, retinopathy, nephropathy, and neuropathy are worse in vulnerable populations among Native Americans, African Americans, and Latinos. The science of evidence-based clinical care guidelines provides a roadmap to health for people with diabetes. However, CDC reports that adherence to care guidelines varies between 50% - 60% of people with diabetes. This gap between science and practice is the rationale for the UNC Center for Diabetes Translation Research to Reduce Health Disparities. The mission of the Center is to transform the health of people with, or at risk for type 1, type 2, or gestational diabetes or related conditions in North Carolina and beyond its borders by advancing translational sciences in North Carolina and beyond that result in primary or secondary prevention of diabetes and its complications. The study aims are 1) develop an integrated set of cores and programs that coalesce and focus existing resources to translate research advances into clinical and community practice that reduce diabetes-related health disparities as measured in part by a) Center utilization, b) tracking subsequent publications and extramural awards, and c) tracking primary outcomes from research findings as a marker for potential public health improvement; 2) leverage existing UNC research infrastructures to enhance the research resources of the Center, including the UNC Diabetes Center, the NC Translational and Clinical Sciences Institute (CTSA), the Sheps Center for Health Services Research, the Lineberger Cancer Center, and other NIDDK funded resources such as the NORC Nutrition Communication for Health Applications, Interventions (CHAI) Core, and relevant NIDDK-funded T32 programs; and 3) develop an Enrichment Program to enhance interactions and promote scientific exchange of translational research methods with diabetes researchers or trainees, and other investigators representing fields relevant to diabetes disparities at UNC-CH and UNC-P and other consortium members. The UNC Center is poised to achieve its aims that may result in increased productivity of diabetes translation science, the health of people with diabetes, and the reduction of health disparities among people with diabetes.