UNC Center for Diabetes Translation Research to Reduce Health Disparities

目前，每10名美国成年人中就有1人(约2400万人)患有2型糖尿病，预测显示，如果目前的趋势继续下去，到2050年，每3人中可能有1人受到影响。糖尿病及其相关心血管疾病、视网膜病变、肾病和神经病变的患病率在美洲原住民、非裔美国人和拉美裔易感人群中更为严重。循证临床护理指南的科学为糖尿病患者提供了健康路线图。然而，CDC报告说，糖尿病患者遵守护理指南的比例在50%-60%之间。科学与实践之间的这种差距是北卡罗来纳大学糖尿病翻译研究中心减少健康差距的理由。该中心的使命是通过在北卡罗来纳州和其他地区推进翻译科学，改善1型、2型、妊娠期糖尿病或相关疾病患者或有患1型、2型、妊娠期糖尿病或相关疾病风险的人的健康状况，从而实现糖尿病及其并发症的一级或二级预防。这项研究的目标是1)开发一套整合的核心和计划，将现有资源集中起来，将研究进展转化为临床和社区实践，以减少糖尿病相关的健康差距，部分衡量标准是a)中心利用率，b)跟踪后续出版物和外部奖励，以及c)跟踪研究结果的初步结果，作为潜在公共健康改善的标志；2)利用现有的北卡罗来纳大学研究基础设施来加强中心的研究资源，包括北卡罗来纳大学糖尿病中心、北卡罗来纳大学糖尿病研究与临床研究所(CTSA)、Sheps医疗服务研究中心、Lineberger癌症中心，以及其他由NIDDK资助的资源，如NORC健康应用营养交流、干预(CHAI)核心计划和NIDDK资助的相关T32计划；以及3)开发一项丰富计划，以加强与糖尿病研究人员或受训人员、代表与糖尿病差异相关领域的其他研究人员在UNC-CH和UNC-P及其他联盟成员之间的科学交流。北卡罗来纳大学中心准备实现其目标，从而提高糖尿病翻译科学的生产率，保护糖尿病患者的健康，并缩小糖尿病患者之间的健康差距。

Currently 1 in 10 US adults (about 24 million people) has Type 2 diabetes, and projections suggest that 1 in 3 people may be affected in 2050 if current trends continue. The prevalence of diabetes and associated cardiovascular disease, retinopathy, nephropathy, and neuropathy are worse in vulnerable populations among Native Americans, African Americans, and Latinos. The science of evidence-based clinical care guidelines provides a roadmap to health for people with diabetes. However, CDC reports that adherence to care guidelines varies between 50% - 60% of people with diabetes. This gap between science and practice is the rationale for the UNC Center for Diabetes Translation Research to Reduce Health Disparities. The mission of the Center is to transform the health of people with, or at risk for type 1, type 2, or gestational diabetes or related conditions in North Carolina and beyond its borders by advancing translational sciences in North Carolina and beyond that result in primary or secondary prevention of diabetes and its complications. The study aims are 1) develop an integrated set of cores and programs that coalesce and focus existing resources to translate research advances into clinical and community practice that reduce diabetes-related health disparities as measured in part by a) Center utilization, b) tracking subsequent publications and extramural awards, and c) tracking primary outcomes from research findings as a marker for potential public health improvement; 2) leverage existing UNC research infrastructures to enhance the research resources of the Center, including the UNC Diabetes Center, the NC Translational and Clinical Sciences Institute (CTSA), the Sheps Center for Health Services Research, the Lineberger Cancer Center, and other NIDDK funded resources such as the NORC Nutrition Communication for Health Applications, Interventions (CHAI) Core, and relevant NIDDK-funded T32 programs; and 3) develop an Enrichment Program to enhance interactions and promote scientific exchange of translational research methods with diabetes researchers or trainees, and other investigators representing fields relevant to diabetes disparities at UNC-CH and UNC-P and other consortium members. The UNC Center is poised to achieve its aims that may result in increased productivity of diabetes translation science, the health of people with diabetes, and the reduction of health disparities among people with diabetes.