UNC Center for Diabetes Translation Research to Reduce Health Disparities

目前，十分之一的美国成年人（约2400万人）患有2型糖尿病，预计如果目前的趋势继续下去，到2050年，三分之一的人可能会受到影响。糖尿病及相关心血管疾病、视网膜病变、肾病和神经病变的患病率在印第安人、非洲裔美国人和拉丁美洲人等弱势人群中更为严重。循证临床护理指南科学为糖尿病患者提供了健康路线图。然而，美国疾病控制与预防中心报告说，糖尿病患者对护理指南的依从性在50% - 60%之间。这种科学与实践之间的差距是北卡罗来纳大学糖尿病转化研究中心减少健康差距的基本原理。该中心的使命是通过推进北卡罗莱纳州和其他地区的转化科学，从而实现糖尿病及其并发症的一级或二级预防，从而改变北卡罗莱纳州和其他地区患有1型、2型或妊娠糖尿病或相关疾病的人的健康状况。本研究的目的是1)开发一套整合的核心和项目，将现有资源整合和集中，将研究进展转化为临床和社区实践，以减少糖尿病相关的健康差异，部分衡量指标为a)中心利用率，b)跟踪后续出版物和校外奖励，以及c)跟踪研究结果的主要结果，作为潜在公共健康改善的标志；2)利用现有的北卡罗来纳大学研究基础设施来增强中心的研究资源，包括北卡罗来纳大学糖尿病中心、北卡罗来纳大学转化与临床科学研究所（CTSA）、谢普斯健康服务研究中心、Lineberger癌症中心和其他NIDDK资助的资源，如北卡罗来纳大学健康应用营养交流、干预（CHAI）核心和相关的NIDDK资助的T32项目；3)制定一个浓缩计划，以加强与UNC-CH和UNC-P的糖尿病研究人员或学员，以及其他代表糖尿病差异相关领域的研究人员以及其他联盟成员之间的互动和促进转化研究方法的科学交流。UNC中心准备实现其目标，这可能导致提高糖尿病转化科学的生产力，糖尿病患者的健康，并减少糖尿病患者之间的健康差距。

Currently 1 in 10 US adults (about 24 million people) has Type 2 diabetes, and projections suggest that 1 in 3 people may be affected in 2050 if current trends continue. The prevalence of diabetes and associated cardiovascular disease, retinopathy, nephropathy, and neuropathy are worse in vulnerable populations among Native Americans, African Americans, and Latinos. The science of evidence-based clinical care guidelines provides a roadmap to health for people with diabetes. However, CDC reports that adherence to care guidelines varies between 50% - 60% of people with diabetes. This gap between science and practice is the rationale for the UNC Center for Diabetes Translation Research to Reduce Health Disparities. The mission of the Center is to transform the health of people with, or at risk for type 1, type 2, or gestational diabetes or related conditions in North Carolina and beyond its borders by advancing translational sciences in North Carolina and beyond that result in primary or secondary prevention of diabetes and its complications. The study aims are 1) develop an integrated set of cores and programs that coalesce and focus existing resources to translate research advances into clinical and community practice that reduce diabetes-related health disparities as measured in part by a) Center utilization, b) tracking subsequent publications and extramural awards, and c) tracking primary outcomes from research findings as a marker for potential public health improvement; 2) leverage existing UNC research infrastructures to enhance the research resources of the Center, including the UNC Diabetes Center, the NC Translational and Clinical Sciences Institute (CTSA), the Sheps Center for Health Services Research, the Lineberger Cancer Center, and other NIDDK funded resources such as the NORC Nutrition Communication for Health Applications, Interventions (CHAI) Core, and relevant NIDDK-funded T32 programs; and 3) develop an Enrichment Program to enhance interactions and promote scientific exchange of translational research methods with diabetes researchers or trainees, and other investigators representing fields relevant to diabetes disparities at UNC-CH and UNC-P and other consortium members. The UNC Center is poised to achieve its aims that may result in increased productivity of diabetes translation science, the health of people with diabetes, and the reduction of health disparities among people with diabetes.