South Carolina Center for Clinical /Translational Resear

描述（由申请人提供）：南卡罗来纳州在慢性疾病（如中风、糖尿病、心脏病和癌症）的患病率方面位居前列，所有这些疾病都不成比例地影响非洲裔美国人，非洲裔美国人占全州人口的30%，占该州农村社区的40%。因此，我们处于独特的地位，进行转化研究，以解决健康差距，这种类型的研究是在我们国家特别重要。南卡罗来纳州的大学有强大的机构支持，跨学院，单位和部门，包括我们的附属医院和组织，加强我们的研究工作的合作研究的文化。我们提出了一个为期一年的规划过程，以设计一个临床和转化研究中心（CCTR），其中基础科学，临床和转化研究人员，沿着利益相关者从医院，社区组织，行业，宗教机构，大学和政府形成团队开发具体的转化研究计划。我们将围绕特定内容领域开发研究组合和基础设施，以促进新知识向床边和社区的移动。这一愿景的组成部分是临床和转化科学家的培训计划，该计划将联合收割机的研究设计和传播课程与新CCTR中集中的应用经验相结合。一个关键的组成部分将是用于衡量业绩标准的评价方法，并最终衡量合同技术审评的有效性。该提案的具体目标是：1）设计一个由四个综合职能部分组成的研究管理核心：行政;方法和信息学;项目和赠款管理以及社区外展。2)设计一个综合计划，以培养临床转化科学家，包括职业中期的临床医生和临床研究人员，“导师学院”，博士后研究员，课程开发，新的研究生课程转化研究，和本科生的研究经验。3)设计一个虚拟的临床转化科学实验室，通过开发一个过程，围绕核心临床研究领域整合研究者和关键利益相关者。4)设计一个评估过程来衡量CCTR规划的有效性。我们希望在资助期结束时，CCTR将开始作为一个高效的转化研究中心运作。

DESCRIPTION (provided by applicant): South Carolina ranks among the highest in the prevalence of chronic diseases such as stroke, diabetes, heart disease, and cancer, all of which disproportionately affect African Americans, who comprise 30% of the population statewide, and 40% in the rural communities in this state. Hence, we are uniquely positioned to conduct translational research to address health disparities, and this type of research is particularly important in our State. The University of South Carolina has strong institutional support, a culture of collaborative research across colleges, units, and departments including our affiliated hospitals and organizations that strengthens our research effort. We propose a one-year planning process to design a Center for Clinical and Translational Research (CCTR) in which basic science, clinical, and translational researchers, along with stakeholders from hospitals, community organizations, industry, faith-based institutions, Universities, and government form teams to develop specific translational research programs. We will develop, around specific content areas, research portfolios and infrastructure that facilitate the movement of new knowledge to the bedside and then the community. Integral to this vision is a training program for clinical and translational scientists that combine coursework in research design and dissemination with applied experience centralized within the new CCTR. A critical component will be the evaluation methodology used to measure performance criteria and ultimately, the effectiveness of the CCTR. The Specific Aims of this proposal are: 1) to design a research administration core comprised of four integrated functional components: administrative; methodology and informatics; projects and grants management, and community outreach. 2) To design an integrated program to train clinical translational scientists to include mid-career clinician and clinician researchers, a "College of Mentors", post-doctoral fellows, curricular development, new graduate programs in translational research, and research experiences for undergraduates. 3) To design a virtual clinical translational science laboratory, by developing a process for integrating investigators and key stakeholders around core clinical research areas. 4) To design an evaluation process to measure the effectiveness of CCTR planning. We expect the CCTR to begin operating as an efficient center for translational research, by the end of the funding period.