Transnasal Probe for Diagnosing Eosinophilic Esophagitis

用于诊断嗜酸性食管炎的经鼻探头

基本信息

  • 批准号:
    8537448
  • 负责人:
  • 金额:
    $ 61.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-08-01 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus, thought to be caused by food allergy, and characterized by the presence of eosinophils within the esophageal mucosa. Even though it is a relatively new disease, EoE is now recognized to be common in both adult and pediatric populations and rapidly rising in incidence. Patients with EoE can experience a variety of upper GI symptoms, ranging from dysphagia to food impaction. Experts fear that if left untreated, EoE may lead to esophageal fibrosis and stricture formation. It is therefore currently recommended that this disease be treated until the symptoms and the eosinophilic infiltrate have resolved. EoE therapy options include corticosteroids and aggressive dietary restriction followed by gradual food reintroduction. While both treatments are effective, EoE returns following cessation of corticosteroids and numerous attempts at food reintroduction are needed to arrive at a diet that provides a good quality of life. As a result, management of EoE patients involves frequent follow up to monitor the patient's clinical and histopathologic response to changes in steroid dosing and/or diet. This strategy is arduous for patients and their families, and costly, as multiple endoscopy sessions must be conducted over time to procure esophageal biopsies and monitor eosinophil counts. We have developed a new technology called spectrally-encoded confocal microscopy (SECM), that is capable of being incorporated into a small-diameter probe and can rapidly obtain depth-resolved microscopic image data over large epithelial areas in vivo. Originally developed to evaluate dysplasia and cancer of the esophagus, we have recently discovered that this imaging modality can also see esophageal eosinophils with a high degree of contrast. Much of the inconvenience and nearly half of the cost of endoscopy is a consequence of patient sedation that is required to perform the endoscopic procedure. In this proposal we will advance the SECM technology so that it can be used to monitor esophageal eosinophils without requiring sedation, endoscopy, or excisional biopsy. We will accomplish this task by developing small, flexible transnasal SECM probe that can be routinely inserted into the esophagus in the outpatient setting. In conjunction with a new high-speed SECM system, this device will automatically image a large portion of the esophagus and count eosinophils. Once the device has been constructed, validation studies will be conducted to demonstrate that the accuracy of this device is comparable to that of endoscopic biopsy. The end product of this research will be an esophageal eosinophil monitoring tool that is less expensive and far better tolerated than the current standard of care. Beyond its immediate clinical impact, this technology can also be used in future investigational studies to expand our knowledge of EoE and other diseases such as asthma that are characterized by tissue eosinophilia.
描述(由申请人提供):嗜酸性食管炎(EoE)是一种食管炎症,被认为是由食物过敏引起的,其特征是食管粘膜内存在嗜酸性粒细胞。尽管这是一种相对较新的疾病,但人们现在认为,EoE在成人和儿科人群中都很常见,而且发病率正在迅速上升。EoE患者可出现各种上消化道症状,从吞咽困难到食物嵌塞。专家担心,如果不及时治疗,EoE可能导致食管纤维化和狭窄形成。因此,目前建议治疗此病,直到症状和嗜酸性粒细胞浸润消失。EoE治疗方案包括皮质类固醇和积极的饮食限制,然后逐渐重新引入食物。虽然这两种治疗方法都有效,但在停止使用皮质类固醇后,EoE会复发,需要多次尝试重新引入食物,以达到提供良好生活质量的饮食。因此,EoE患者的管理需要经常随访,以监测患者对类固醇剂量和/或饮食变化的临床和组织病理学反应。这一策略对患者及其家属来说是艰巨的,而且费用昂贵,因为必须在一段时间内进行多次内窥镜检查,以获得食管活检和监测嗜酸性粒细胞计数。我们开发了一种称为光谱编码共聚焦显微镜(SECM)的新技术,该技术能够集成到小直径探针中,并且可以快速获得体内大上皮区域的深度分辨率显微图像数据。最初用于评估食道发育不良和癌症,我们最近发现这种成像方式也可以在高对比度下看到食管嗜酸性粒细胞。内窥镜检查的大部分不便和近一半的费用是由于患者在进行内窥镜检查过程中需要镇静。在本提案中,我们将推进SECM技术,使其可用于监测食管嗜酸性粒细胞,而无需镇静,内窥镜检查或切除活检。我们将通过开发小型、灵活的经鼻SECM探针来完成这项任务,该探针可以在门诊常规插入食管。与新的高速SECM系统结合使用,该设备将自动成像大部分食道并计数嗜酸性粒细胞。一旦设备建成,将进行验证研究,以证明该设备的准确性与内窥镜活检相当。这项研究的最终成果将是一种食管嗜酸性粒细胞监测工具,它比目前的护理标准更便宜,耐受性也更好。除了直接的临床影响外,这项技术还可以用于未来的调查研究,以扩大我们对EoE和其他以组织嗜酸性粒细胞增多为特征的疾病(如哮喘)的认识。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Guillermo J Tearney其他文献

Assessment of Lipid Rich Plaque Containing Necrotic Core Using a Multi-Modality Near-Infrared Autofluorescence and Optical Coherence Tomography Imaging System
使用多模态近红外自发荧光和光学相干断层扫描成像系统评估含有坏死核心的富脂斑块
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kohei Watanabe;Joseph A Gardecki;Kensuke Nishimiya;Zhonglie Piao;Daisuke Yamada;Guillermo J Tearney
  • 通讯作者:
    Guillermo J Tearney
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
孟加拉国、巴基斯坦和赞比亚营养不良儿童队列研究与美国儿童相比的环境性肠功能障碍的组织病理学基础
  • DOI:
    10.1016/j.ajcnut.2024.02.028
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Paul Kelly;Kelley VanBuskirk;David Coomes;Samer Mouksassi;Gerald Smith;Zehra Jamil;Md Shabab Hossain;Sana Syed;Chelsea Marie;Phillip I Tarr;Peter B Sullivan;William A Petri;Donna M Denno;Tahmeed Ahmed;Mustafa Mahfuz;S Asad Ali;Sean R Moore;I Malick Ndao;Guillermo J Tearney;Ömer H Yilmaz;Kanekwa Zyambo
  • 通讯作者:
    Kanekwa Zyambo
Technology Insight: optical coherence tomography—current status and future development
技术洞察:光学相干断层扫描——现状与未来发展
  • DOI:
    10.1038/ncpcardio0482
  • 发表时间:
    2006-03-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Adrian F Low;Guillermo J Tearney;Brett E Bouma;Ik-Kyung Jang
  • 通讯作者:
    Ik-Kyung Jang

Guillermo J Tearney的其他文献

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{{ truncateString('Guillermo J Tearney', 18)}}的其他基金

Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy
使用多模态系留胶囊图像引导活检筛查巴雷特食管进展者
  • 批准号:
    10708177
  • 财政年份:
    2022
  • 资助金额:
    $ 61.81万
  • 项目类别:
Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy
使用多模态系留胶囊图像引导活检筛查巴雷特食管进展者
  • 批准号:
    10591985
  • 财政年份:
    2022
  • 资助金额:
    $ 61.81万
  • 项目类别:
A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
用于改善上消化道诊断的系留胶囊内镜-内镜 (TEEM) 方法
  • 批准号:
    10327702
  • 财政年份:
    2019
  • 资助金额:
    $ 61.81万
  • 项目类别:
A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
用于改善上消化道诊断的系留胶囊内镜-内镜 (TEEM) 方法
  • 批准号:
    10078943
  • 财政年份:
    2019
  • 资助金额:
    $ 61.81万
  • 项目类别:
Less invasive assessment of inflammation and subepithelial remodeling in eosinophilic esophagitis patients
嗜酸性粒细胞性食管炎患者炎症和上皮下重塑的微创评估
  • 批准号:
    9762923
  • 财政年份:
    2018
  • 资助金额:
    $ 61.81万
  • 项目类别:
Less invasive assessment of inflammation and subepithelial remodeling in eosinophilic esophagitis patients
嗜酸性粒细胞性食管炎患者炎症和上皮下重塑的微创评估
  • 批准号:
    10210260
  • 财政年份:
    2018
  • 资助金额:
    $ 61.81万
  • 项目类别:
Natural History of Barrett's Esophagus Using Capsule Endomicroscopy
使用胶囊内镜检查巴雷特食管的自然史
  • 批准号:
    9277434
  • 财政年份:
    2014
  • 资助金额:
    $ 61.81万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    9097686
  • 财政年份:
    2014
  • 资助金额:
    $ 61.81万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    8760911
  • 财政年份:
    2014
  • 资助金额:
    $ 61.81万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    9518853
  • 财政年份:
    2014
  • 资助金额:
    $ 61.81万
  • 项目类别:
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