Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

使用多模态系留胶囊图像引导活检筛查巴雷特食管进展者

基本信息

  • 批准号:
    10591985
  • 负责人:
  • 金额:
    $ 64.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-30 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Esophageal adenocarcinoma (EAC) is a deadly cancer that is preceded by a metaplastic change called Barrett's esophagus (BE). It has long been thought that endoscopic screening for BE followed by endoscopic surveillance can significantly decrease the mortality of EAC. This unfortunately has not borne out as the cost and inconvenience of conscious sedation prohibits endoscopy from being used as a population-based screening tool. BE screening may become possible in the future, owing to innovative swallowable tethered capsule endomicroscopes or cell sampling devices that can detect BE without requiring sedation. Yet, even if these capsules were to identify the large number of people in the US who have BE (~15M), endoscopic surveillance of this group would be prohibitively expensive. If we could use tissue biomarkers to identify the 5% of those with BE who will develop EAC in their lifetimes, then endoscopic intervention could be given to those who really need it, and those with low-risk BE would not require further follow up. Recognition of this need has motivated the field to identify BE progression biomarkers derived from esophageal tissue samples obtained by autofluorescence/reflectance-targeted endoscopy. This research has identified biomarkers such as aneuploidy and aberrant p53/cyclin A expression as strong predictors of BE progression. Unfortunately, the only way to target and obtain these tissues today is through sedated endoscopy. With the modifications proposed here, a new BE screening technology that we have developed called optical coherence tomography (OCT) tethered capsule endomicroscopy (TCE), could enable targeted biopsy without sedation. OCT-TCE obtains 3D microscopic images of the entire esophagus in unsedated subjects, accurately identifies BE, and has been successfully used by nurses and technicians in primary care settings. Here, we propose to advance OCT-TCE for targeted biopsy by adding autofluorescence and reflectance spectral imaging technology that can help identify tissue enriched in molecular alterations associated with BE progression risk. The new capsule will also have a cryobiopsy mechanism for acquiring targeted tissue samples under real time image guidance. In Aim 1 of this proposal, we will develop this multimodality TCE with biopsy (MM-TCEB) device and show that it works as intended in a study of 20 BE patients. Then, we will conduct a clinical study in 100 unsedated BE patients to demonstrate that MM-TCEB collects tissue and identifies BE progression biomarkers as well as sedated endoscopy. In Aim 3, we will develop image analysis and deep learning algorithms to mine the Aim 2 data, uncovering new relationships between OCT, autofluorescence, and reflectance spectroscopy and tissue-derived BE progression biomarkers. By acquiring targeted biopsies using a swallowable tethered capsule in unsedated subjects, MM-TCEB can become a powerful technique for obtaining esophageal tissue samples for BE progression biomarker discovery, validation, and ultimately population-based screening.
食管腺癌(EAC)是一种致命的癌症,在发生之前会发生一种叫做巴雷特的化生变化

项目成果

期刊论文数量(0)
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Guillermo J Tearney其他文献

Assessment of Lipid Rich Plaque Containing Necrotic Core Using a Multi-Modality Near-Infrared Autofluorescence and Optical Coherence Tomography Imaging System
使用多模态近红外自发荧光和光学相干断层扫描成像系统评估含有坏死核心的富脂斑块
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kohei Watanabe;Joseph A Gardecki;Kensuke Nishimiya;Zhonglie Piao;Daisuke Yamada;Guillermo J Tearney
  • 通讯作者:
    Guillermo J Tearney
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
孟加拉国、巴基斯坦和赞比亚营养不良儿童队列研究与美国儿童相比的环境性肠功能障碍的组织病理学基础
  • DOI:
    10.1016/j.ajcnut.2024.02.028
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Paul Kelly;Kelley VanBuskirk;David Coomes;Samer Mouksassi;Gerald Smith;Zehra Jamil;Md Shabab Hossain;Sana Syed;Chelsea Marie;Phillip I Tarr;Peter B Sullivan;William A Petri;Donna M Denno;Tahmeed Ahmed;Mustafa Mahfuz;S Asad Ali;Sean R Moore;I Malick Ndao;Guillermo J Tearney;Ömer H Yilmaz;Kanekwa Zyambo
  • 通讯作者:
    Kanekwa Zyambo
Technology Insight: optical coherence tomography—current status and future development
技术洞察:光学相干断层扫描——现状与未来发展
  • DOI:
    10.1038/ncpcardio0482
  • 发表时间:
    2006-03-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Adrian F Low;Guillermo J Tearney;Brett E Bouma;Ik-Kyung Jang
  • 通讯作者:
    Ik-Kyung Jang

Guillermo J Tearney的其他文献

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{{ truncateString('Guillermo J Tearney', 18)}}的其他基金

Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy
使用多模态系留胶囊图像引导活检筛查巴雷特食管进展者
  • 批准号:
    10708177
  • 财政年份:
    2022
  • 资助金额:
    $ 64.35万
  • 项目类别:
A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
用于改善上消化道诊断的系留胶囊内镜-内镜 (TEEM) 方法
  • 批准号:
    10327702
  • 财政年份:
    2019
  • 资助金额:
    $ 64.35万
  • 项目类别:
A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
用于改善上消化道诊断的系留胶囊内镜-内镜 (TEEM) 方法
  • 批准号:
    10078943
  • 财政年份:
    2019
  • 资助金额:
    $ 64.35万
  • 项目类别:
Less invasive assessment of inflammation and subepithelial remodeling in eosinophilic esophagitis patients
嗜酸性粒细胞性食管炎患者炎症和上皮下重塑的微创评估
  • 批准号:
    9762923
  • 财政年份:
    2018
  • 资助金额:
    $ 64.35万
  • 项目类别:
Less invasive assessment of inflammation and subepithelial remodeling in eosinophilic esophagitis patients
嗜酸性粒细胞性食管炎患者炎症和上皮下重塑的微创评估
  • 批准号:
    10210260
  • 财政年份:
    2018
  • 资助金额:
    $ 64.35万
  • 项目类别:
Natural History of Barrett's Esophagus Using Capsule Endomicroscopy
使用胶囊内镜检查巴雷特食管的自然史
  • 批准号:
    9277434
  • 财政年份:
    2014
  • 资助金额:
    $ 64.35万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    9097686
  • 财政年份:
    2014
  • 资助金额:
    $ 64.35万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    8760911
  • 财政年份:
    2014
  • 资助金额:
    $ 64.35万
  • 项目类别:
Celiac Disease Diagnosis using Tethered Capsule Endomicroscopy
使用系留胶囊内镜检查进行乳糜泻诊断
  • 批准号:
    9518853
  • 财政年份:
    2014
  • 资助金额:
    $ 64.35万
  • 项目类别:
Transnasal Probe for Diagnosing Eosinophilic Esophagitis
用于诊断嗜酸性食管炎的经鼻探头
  • 批准号:
    8537448
  • 财政年份:
    2011
  • 资助金额:
    $ 64.35万
  • 项目类别:

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阐明额外染色体消除对嵌合非整倍体综合征的影响:以 Pallister-Killian 综合征为模型
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