Botanicals and Metabolic Syndrome

植物药和代谢综合症

• 批准号: 8543509
• 负责人: William T. Cefalu
• 金额: $ 158.9万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8543509
• 关键词: Agriculture; Animals; Artemisia; Asclepias; Attenuated; Biology; Biomedical Research; Biotechnology; Botanicals; Cardiovascular Diseases; Desire for food; Development; Energy Metabolism; Environment; Epidemic; Evaluation; Functional disorder; Goals; Health; Human; Hypericum perforatum; Insulin; Insulin Receptor; Insulin Resistance; Louisiana; Metabolic syndrome; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathologic Processes; Phase; Physiological; Prevalence; Proteomics; Public Health; Receptor Signaling; Research; Research Personnel; Research Project Grants; Resistance development; Societies; System; Technology; Translating; Universities; Weight; adipocyte differentiation; adipokines; dietary supplements; energy balance; improved; insulin sensitivity; metabolomics; public health relevance

DESCRIPTION (provided by applicant): This application is for a renewal of our Dietary Supplement Research Center focusing on Botanicals. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Biotechnology Center for Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. As the prevalence of metabolic syndrome is reaching epidemic proportions worldwide, metabolic syndrome has been, and will continue to be, one of the most important public health problems facing society. Our Botanical Research Center will consist of three (3) research projects, an Integrative Biology Core, a Botanical core and an Administrative core. Each of the research projects will evaluate specific botanicals and assess the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. Project 1 investigators will conduct studies to evaluate mechanisms of action by which selected extracts of Artemisia sp. modulate insulin receptor signaling and insulin sensitivity in both animal and in early phase human studies. Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action. Project 3 investigators will evaluate how Asclepias incarnata modulates central mechanisms controlling appetite and energy expenditure as a means to improve overall energy balance and weight. We propose to use cutting-edge technologies that include metabolomic profiling, proteomic assessments, and bioaccessibility determinations. Thus, the scientific goal of our Center is to provide a comprehensive evaluation of specific, compelling hypotheses about the molecular, cellular and physiological mechanisms by which botanicals can modulate the development of the underlying pathophysiologic mechanisms of, and attenuate the development to, metabolic syndrome.

描述（由申请人提供）：本申请是我们的膳食补充剂研究中心的更新，重点是植物药。我们的植物研究中心是路易斯安那州立大学（LSU）系统的彭宁顿生物医学研究中心和罗格斯大学农业和环境生物技术中心之间的合作努力。该中心的主题是“植物药和代谢综合征”。“代谢综合征”定义了一种人类状况，其主要特征包括肥胖、胰岛素抵抗、2型糖尿病的发展和加速的心血管疾病。随着代谢综合征在全球范围内的流行，代谢综合征已经并将继续成为社会面临的最重要的公共卫生问题之一。我们的植物学研究中心将包括三（3）个研究项目，一个综合生物学核心，一个植物学核心和一个行政核心。每个研究项目将评估特定的植物药，并评估对代谢综合征病理生理学和发展的细胞机制的影响。项目1的研究人员将进行研究，以评估在动物和早期人类研究中，蒿属植物的提取物调节胰岛素受体信号传导和胰岛素敏感性的作用机制。项目2的研究者将集中于青蒿提取物和贯叶连翘提取物的作用机制。(St. John's Wort）影响脂肪细胞发育、脂肪因子和胰岛素作用。项目3研究人员将评估Asclepias incarnata如何调节控制食欲和能量消耗的中枢机制，以改善整体能量平衡和体重。我们建议使用尖端技术，包括代谢组学分析，蛋白质组学评估和生物可及性测定。因此，我们中心的科学目标是提供一个具体的，令人信服的分子，细胞和生理机制的假说，植物可以调节的基础病理生理机制的发展，并减弱发展，代谢综合征的全面评估。