Botanical Research Core/David M. Ribnicky
植物研究核心/David M. Ribnicky
基本信息
- 批准号:8006962
- 负责人:
- 金额:$ 33.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-04-01 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:ArtsBiochemicalBiologicalBiological AvailabilityBiological TestingBiologyBotanicalsClinicalDataDietDrug FormulationsEquipmentEvaluationFundingFutureHigh Pressure Liquid ChromatographyIn VitroInvestigationMeasurementMetabolic syndromeMethodsMissionModelingModemsPhytochemicalPilot ProjectsPlant SourcesPlantsPlasmaPreparationProductionProtocols documentationQuality ControlRecommendationReproducibilityResearchResearch ActivityResearch PersonnelResearch Project GrantsResearch TrainingServicesSolventsStandardizationStructural ChemistrySyndromeTechniquesTestingTrainingTraining ProgramsTraining and EducationUniversitiesWorkbasedesigngastrointestinalimprovedin vivo Modelinstrumentpre-clinical researchresearch studyresponseskillstool
项目摘要
The Botanical Core of the BRC on Botanicals and Metabolic Syndrome will facilitate the work of all Research Projects, the Integrative Biology Core (IBC) and the Pilot Research and Training Programs. The Botanical Core uses state-of-the-art phytochemical discovery, characterization, standardization and production approaches and modem equipment and greenhouse facilities to perform its mission which include the following specific aims:
Aim 1. The Botanical Core supports the activities of each research project, the IBC and the pilot studies by providing specific services, biochemical tools and methods including: greenhouse-based cultivation of source plants and optimized production of bioactives, production of botanicals for the Center's research, pre-clinical, clinical and pilot studies, activity-guided isolation of bioactives and characterization of their interactions, analytical and structural chemistry support for the research activities, quality control and botanical authentication when necessary and determination of the bioaccessibility and bioavailability of identified active compounds using a gastrointestinal model and plasma analysis.
Aim 2. The Botanical Core collaborates with PIs and with intemal committees to design and perform the experiments and to interpret the results from projects, coordinate plant cultivation, preparation of extracts, fractions and compounds with the PIs' needs for biological testing, develop methods for expedited testing, relate observed biological response to bioaccessibility and bioavailability data.
Aim 3. The Botanical Core assists in design and conduct of pilot studies and in the education and training of new investigators for biobotanical research, provides specific recommendations and/or evaluations of the quality and sourcing of botanical materials to be used for proposed pilot studies and provides all necessary training to investigators and T32 fellows requiring specific skills for the evaluation and use of botanical preparations for in vitro and in vivo models related to metabolic syndrome.
Aim 4. The Botanical Core conducts original research with the following objectives: improve materials, methods and instruments for ongoing projects, create enabling approaches in the advance of new projects, and to continue to screen and identify new candidates and future projects.
BRC植物学和代谢综合征的植物学核心将促进所有研究项目,综合生物学核心(IBC)和试点研究和培训计划的工作。植物核心利用最先进的植物化学发现、表征、标准化和生产方法以及现代设备和温室设施来执行其使命,其中包括以下具体目标:
目标1.植物学核心通过提供具体服务、生物化学工具和方法,支持每个研究项目、国际生物伦理委员会和试点研究的活动,包括:基于温室的源植物栽培和生物活性物质的优化生产,为中心的研究,临床前,临床和试点研究生产植物药,生物活性物质的活性指导分离及其相互作用的表征,为研究活动提供分析和结构化学支持,必要时进行质量控制和植物认证,并使用胃肠道模型和血浆分析确定已鉴定活性化合物的生物可及性和生物利用度。
目标二。植物学核心与PI和内部委员会合作,设计和执行实验,解释项目结果,协调植物栽培,提取物,馏分和化合物的制备与PI的生物学测试需求,开发快速测试方法,将观察到的生物反应与生物可及性和生物利用度数据联系起来。
目标3.植物学核心协助设计和进行试点研究,并教育和培训新的生物植物学研究调查人员,提出具体建议和/或或评价拟用于拟议试点研究的植物材料的质量和来源,并为研究人员和T32研究员提供所有必要的培训,这些研究员和T32研究员需要评价和使用体外和体内植物制剂的特殊技能。代谢综合征相关的体内模型。
目标4。植物学核心进行原创性研究,其目标如下:为正在进行的项目改进材料、方法和仪器,在新项目的推进中创造有利的方法,并继续筛选和确定新的候选人和未来的项目。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
William T. Cefalu其他文献
Canagliflozin Demonstrates Durable Glycemic Improvements Over 104 Weeks Compared with Glimepiride in Subjects with Type 2 Diabetes Mellitus on Metformin
- DOI:
10.1016/j.jcjd.2013.08.081 - 发表时间:
2013-10-01 - 期刊:
- 影响因子:
- 作者:
Lawrence A. Leiter;Gisle Langslet;William T. Cefalu;Kun Ho Yoon;Pablo Arias;John Xie;Dainus Balis;Dawn Millington;Frank Vercruysse;William Canovatchel;Gary Meininger - 通讯作者:
Gary Meininger
Insulin Sensitizers Versus Secretagogues as First‐Line Therapy for Diabetes: Rationale for Clinical Choice
胰岛素增敏剂与促泌剂作为糖尿病一线治疗:临床选择的理由
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Robert J. Richards;L. Yvonne Melendez;William T. Cefalu - 通讯作者:
William T. Cefalu
Clinical validation of a second-generation fructosamine assay.
第二代果糖胺测定的临床验证。
- DOI:
- 发表时间:
1991 - 期刊:
- 影响因子:9.3
- 作者:
William T. Cefalu;William T. Cefalu;A. Bell;A. Bell;Marie Petty;Marie Petty;Camille Izlar;Camille Izlar;Jeffrey A. Smith;Jeffrey A. Smith - 通讯作者:
Jeffrey A. Smith
The new diabetes inhalers: New tools for the clinician
- DOI:
10.1007/s11892-007-0026-2 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:6.400
- 作者:
William T. Cefalu - 通讯作者:
William T. Cefalu
Correlation of Serum Fructosamine Activity in Type i Diabetic Children
- DOI:
10.1097/00000441-198904000-00009 - 发表时间:
1989-04-01 - 期刊:
- 影响因子:
- 作者:
William T. Cefalu;Etienne Mejia;George R. Puente;Debbie Fleishhacker;Kathryn Macaulay - 通讯作者:
Kathryn Macaulay
William T. Cefalu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('William T. Cefalu', 18)}}的其他基金
HRT TO AUGMENT LOSS OF VISCERAL FAT AND IMPROVE INSULIN SENSITIVITY
激素替代疗法可增加内脏脂肪的减少并提高胰岛素敏感性
- 批准号:
7206931 - 财政年份:2005
- 资助金额:
$ 33.52万 - 项目类别:
Artemisia SP and Insulin Action/William T. Cefalu
蒿 SP 和胰岛素作用/William T. Cefalu
- 批准号:
8006899 - 财政年份:2005
- 资助金额:
$ 33.52万 - 项目类别:
Integrative Biology Core/Thomas W. Gettys
综合生物学核心/Thomas W. Gettys
- 批准号:
8339167 - 财政年份:2005
- 资助金额:
$ 33.52万 - 项目类别:
Chromium, Cellular Energy Status, Whole Body Energy Bala
铬、细胞能量状态、全身能量巴拉
- 批准号:
6963437 - 财政年份:2005
- 资助金额:
$ 33.52万 - 项目类别:
Pregnane and Glycosides and Obesity/llya Raskin
孕烷和糖苷与肥胖/llya Raskin
- 批准号:
8006959 - 财政年份:2005
- 资助金额:
$ 33.52万 - 项目类别:
相似海外基金
Elucidating the molecular basis and expanding the biological applications of the glycosyltransferases using biochemical and structural biology approaches
利用生化和结构生物学方法阐明糖基转移酶的分子基础并扩展其生物学应用
- 批准号:
23K14138 - 财政年份:2023
- 资助金额:
$ 33.52万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Analytical validation of a biochemical test for alpha-synuclein aggregates in biological fluids for the diagnosis of Parkinson's Disease
用于诊断帕金森病的生物体液中 α-突触核蛋白聚集体的生化测试的分析验证
- 批准号:
10396678 - 财政年份:2021
- 资助金额:
$ 33.52万 - 项目类别:
Analytical validation of a biochemical test for alpha-synuclein aggregates in biological fluids for the diagnosis of Parkinson's Disease
用于诊断帕金森病的生物体液中 α-突触核蛋白聚集体的生化测试的分析验证
- 批准号:
10361903 - 财政年份:2021
- 资助金额:
$ 33.52万 - 项目类别:
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological Systems
生物系统适应的分子机制和生化回路
- 批准号:
10248476 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
Shining a light on dense granules- biochemical, genetic and cell biological investigation of an essential but understudied compartment in malarial -
揭示致密颗粒——对疟疾中一个重要但尚未充分研究的隔室进行生化、遗传和细胞生物学研究——
- 批准号:
2243093 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
Studentship
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological Systems
生物系统适应的分子机制和生化回路
- 批准号:
10687856 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological Systems
生物系统适应的分子机制和生化回路
- 批准号:
10005386 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological Systems
生物系统适应的分子机制和生化回路
- 批准号:
10480082 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
Investigation into the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects
空气污染对人体皮肤功能的生化、生物学影响及其干预研究
- 批准号:
2314361 - 财政年份:2018
- 资助金额:
$ 33.52万 - 项目类别:
Studentship
Investigation into the biochemical and biological effects of air pollution on the function of human skin and the intervention of such effects
空气污染对人体皮肤功能的生化、生物学影响及其干预研究
- 批准号:
BB/S506837/1 - 财政年份:2018
- 资助金额:
$ 33.52万 - 项目类别:
Training Grant