Botanical Research Core/David M. Ribnicky
Botanical Research Core/David M. Ribnicky
批准号:
8006962
负责人:
William T. Cefalu
金额:
$33.52万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-04-01 至 2015-08-31
关键词:
ArtsBiochemicalBiologicalBiological AvailabilityBiological TestingBiologyBotanicalsClinicalDataDietDrug FormulationsEquipmentEvaluationFundingFutureHigh Pressure Liquid ChromatographyIn VitroInvestigationMeasurementMetabolic syndromeMethodsMissionModelingModemsPhytochemicalPilot ProjectsPlant SourcesPlantsPlasmaPreparationProductionProtocols documentationQuality ControlRecommendationReproducibilityResearchResearch ActivityResearch PersonnelResearch Project GrantsResearch TrainingServicesSolventsStandardizationStructural ChemistrySyndromeTechniquesTestingTrainingTraining ProgramsTraining and EducationUniversitiesWorkbasedesigngastrointestinalimprovedin vivo Modelinstrumentpre-clinical researchresearch studyresponseskillstool
中文摘要
植物和代谢综合征BRC的植物学核心将促进所有研究项目、综合生物学核心(IBC)和试点研究和培训计划的工作。植物中心使用最先进的植物化学发现、表征、标准化和生产方法,以及现代化的设备和温室设施来执行其任务,包括以下具体目标:
英文摘要
The Botanical Core of the BRC on Botanicals and Metabolic Syndrome will facilitate the work of all Research Projects, the Integrative Biology Core (IBC) and the Pilot Research and Training Programs. The Botanical Core uses state-of-the-art phytochemical discovery, characterization, standardization and production approaches and modem equipment and greenhouse facilities to perform its mission which include the following specific aims:
Aim 1. The Botanical Core supports the activities of each research project, the IBC and the pilot studies by providing specific services, biochemical tools and methods including: greenhouse-based cultivation of source plants and optimized production of bioactives, production of botanicals for the Center's research, pre-clinical, clinical and pilot studies, activity-guided isolation of bioactives and characterization of their interactions, analytical and structural chemistry support for the research activities, quality control and botanical authentication when necessary and determination of the bioaccessibility and bioavailability of identified active compounds using a gastrointestinal model and plasma analysis.
Aim 2. The Botanical Core collaborates with PIs and with intemal committees to design and perform the experiments and to interpret the results from projects, coordinate plant cultivation, preparation of extracts, fractions and compounds with the PIs' needs for biological testing, develop methods for expedited testing, relate observed biological response to bioaccessibility and bioavailability data.
Aim 3. The Botanical Core assists in design and conduct of pilot studies and in the education and training of new investigators for biobotanical research, provides specific recommendations and/or evaluations of the quality and sourcing of botanical materials to be used for proposed pilot studies and provides all necessary training to investigators and T32 fellows requiring specific skills for the evaluation and use of botanical preparations for in vitro and in vivo models related to metabolic syndrome.
Aim 4. The Botanical Core conducts original research with the following objectives: improve materials, methods and instruments for ongoing projects, create enabling approaches in the advance of new projects, and to continue to screen and identify new candidates and future projects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Administrative Core
-
批准号:7499827
-
项目类别:
-
资助金额:$17.1万
-
财政年份:2007
-
负责人:William T. Cefalu
-
依托单位:
Artemisia SP and Insulin Action/William T. Cefalu
-
批准号:8006899
-
项目类别:
-
资助金额:$52.76万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:7626062
-
项目类别:
-
资助金额:$145.65万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Administrative Core
-
批准号:6946067
-
项目类别:
-
资助金额:$28.39万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
HRT TO AUGMENT LOSS OF VISCERAL FAT AND IMPROVE INSULIN SENSITIVITY
-
批准号:7206931
-
项目类别:
-
资助金额:$2.13万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:8543509
-
项目类别:
-
资助金额:$158.9万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Integrative Biology Core/Thomas W. Gettys
-
批准号:8339167
-
项目类别:
-
资助金额:$33.63万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:7846969
-
项目类别:
-
资助金额:$24.32万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Chromium, Cellular Energy Status, Whole Body Energy Bala
-
批准号:6963437
-
项目类别:
-
资助金额:$22.05万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Pregnane and Glycosides and Obesity/llya Raskin
-
批准号:8006959
-
项目类别:
-
资助金额:$27.22万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:7998300
-
项目类别:
-
资助金额:$150.83万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:7227130
-
项目类别:
-
资助金额:$145.65万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
PMI-5011 and Insulin Action
-
批准号:6946057
-
项目类别:
-
资助金额:$21.84万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Adipocytes and Botanicals/Jacequeline M. Stephens
-
批准号:8339164
-
项目类别:
-
资助金额:$23.59万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Chromium, Cellular Energy Status and Whole Body Energy Balance
-
批准号:7140083
-
项目类别:
-
资助金额:$21.53万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:8650486
-
项目类别:
-
资助金额:$9.55万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanical Research Core/David M. Ribnicky
-
批准号:8339166
-
项目类别:
-
资助金额:$37.06万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:8136232
-
项目类别:
-
资助金额:$146.15万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:6910409
-
项目类别:
-
资助金额:$149.97万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
Botanicals and Metabolic Syndrome
-
批准号:8263916
-
项目类别:
-
资助金额:$16.08万
-
财政年份:2005
-
负责人:William T. Cefalu
-
依托单位:
海外基金