The Role of ABCC6 In Chronic & Acute Cardiovascular Mineralization
ABCC6 在慢性病中的作用
基本信息
- 批准号:8433315
- 负责人:
- 金额:$ 34.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-02-24 至 2016-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAffectAgingArterial Fatty StreakAtherosclerosisBackcrossingsBindingBlood CirculationBlood VesselsCardiacCardiovascular systemCell membraneCellular translocationChronicChronic Kidney FailureComplementComplexCoronary arteryDataDepositionDermalDiabetes MellitusDigestionDiseaseDistalDystrophic CalcificationElderlyGene ExpressionGenesGoalsHealthHealthcareHepaticHepatocyteHereditary DiseaseHumanHydrolysisHyperlipidemiaIn VitroInflammatoryInheritedInjection of therapeutic agentInjuryKidney FailureKnock-outKnockout MiceLigationLinkLiverLocationMechanicsMediatingMetabolicMineralsModificationMolecularMouse ProteinMusMutationPathologic ProcessesPathologyPathway interactionsPatientsPhenotypePopulationPredispositionProteinsPseudoxanthoma ElasticumPublishingRegulationRoleTailTestingThalassemiaTissuesTrypsinVascular calcificationVeinsWild Type MouseWorkcalcificationcalcification inhibitordisease-causing mutationhuman diseasehypercholesterolemiaimprovedin vivoinhibitor/antagonistloss of function mutationmineralizationmouse modelmutantnovelprotein structure functionresponserestoration
项目摘要
DESCRIPTION (provided by applicant): Abnormal mineralization occurs in the context of several common conditions, including advanced age, diabetes, hypercholesterolemia, chronic renal failure and certain genetic conditions. Loss-of-function mutations in the ABCC6 gene cause chronic or acute forms of dystrophic mineralization in diseases such as Pseudoxanthoma elasticum (PXE) and dystrophic cardiac calcification (DCC). These pathologies are characterized by mineralization of cardiovascular and/or dermal tissues. PXE is heritable while DCC is an acquired phenotype resulting from cardiovascular insults. We have obtained preliminary data that suggest that ABCC6 initiates and modulates a calcification inhibitor pathway with a crucial role in both acute and chronic dystrophic calcification. We hypothesize that the loss of ABCC6 function in liver produces an imbalance of modulators of calcification in cardiovascular tissues either directly or through increased levels or modification of a circulating factor. To test this hypothesis, we will use a mouse models to characterize the effects of ABCC6 mutations on the structure and function of the protein, determine the response of Abcc6-/- mice to acute ischemic cardiac injuries and determine the role of Abcc6-/- in the calcification of the atherosclerotic plaque.
描述(由申请人提供):异常矿化发生在几种常见情况下,包括高龄、糖尿病、高胆固醇血症、慢性肾衰竭和某些遗传疾病。ABCC6基因的功能缺失突变导致弹性假黄瘤(PXE)和营养不良心脏钙化(DCC)等疾病的慢性或急性营养不良矿化。这些病理的特点是心血管和/或皮肤组织矿化。PXE是遗传的,而DCC是由心血管损伤引起的获得性表型。我们已经获得的初步数据表明,ABCC6启动和调节钙化抑制剂途径,在急性和慢性营养不良钙化中都起着至关重要的作用。我们假设肝脏中ABCC6功能的丧失直接或通过循环因子水平的增加或修饰导致心血管组织中钙化调节剂的失衡。为了验证这一假设,我们将使用小鼠模型来表征ABCC6突变对蛋白质结构和功能的影响,确定ABCC6 -/-小鼠对急性缺血性心脏损伤的反应,并确定ABCC6 -/-在动脉粥样硬化斑块钙化中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
WILLIAM A BOISVERT其他文献
WILLIAM A BOISVERT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('WILLIAM A BOISVERT', 18)}}的其他基金
The role of ABCC6 in chronic and acute cardiovascular mineralization
ABCC6 在慢性和急性心血管矿化中的作用
- 批准号:
8236848 - 财政年份:2012
- 资助金额:
$ 34.51万 - 项目类别:
The Role of ABCC6 In Chronic & Acute Cardiovascular Mineralization
ABCC6 在慢性病中的作用
- 批准号:
8798686 - 财政年份:2012
- 资助金额:
$ 34.51万 - 项目类别:
The Role of ABCC6 In Chronic & Acute Cardiovascular Mineralization
ABCC6 在慢性病中的作用
- 批准号:
8605215 - 财政年份:2012
- 资助金额:
$ 34.51万 - 项目类别:
Rho kinase in immune-mediated atherosclerosis
Rho 激酶在免疫介导的动脉粥样硬化中的作用
- 批准号:
7996473 - 财政年份:2007
- 资助金额:
$ 34.51万 - 项目类别:
Rho kinase in immune-mediated atherosclerosis
Rho 激酶在免疫介导的动脉粥样硬化中的作用
- 批准号:
7414542 - 财政年份:2007
- 资助金额:
$ 34.51万 - 项目类别:
Rho kinase in immune-mediated atherosclerosis
Rho 激酶在免疫介导的动脉粥样硬化中的作用
- 批准号:
7259970 - 财政年份:2007
- 资助金额:
$ 34.51万 - 项目类别:
Rho kinase in immune-mediated atherosclerosis
Rho 激酶在免疫介导的动脉粥样硬化中的作用
- 批准号:
7813871 - 财政年份:2007
- 资助金额:
$ 34.51万 - 项目类别:
Anti-inflammatory Cytokines in Atherosclerosis
动脉粥样硬化中的抗炎细胞因子
- 批准号:
7270467 - 财政年份:2005
- 资助金额:
$ 34.51万 - 项目类别:
Anti-inflammatory Cytokines in Atherosclerosis
动脉粥样硬化中的抗炎细胞因子
- 批准号:
7480215 - 财政年份:2005
- 资助金额:
$ 34.51万 - 项目类别:
Anti-inflammatory Cytokines in Atherosclerosis
动脉粥样硬化中的抗炎细胞因子
- 批准号:
6984242 - 财政年份:2005
- 资助金额:
$ 34.51万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 34.51万 - 项目类别:
Research Grant