TAS::75 0872::TAS ARIC DATA COORDINATING CENTER

ARIC 是一项在美国四个社区进行的前瞻性流行病学研究：马里兰州华盛顿县；北卡罗来纳州福赛斯县；杰克逊，MS；和明尼苏达州明尼阿波利斯。该研究旨在监测社区冠心病（CHD）和心力衰竭的发病率和死亡率趋势，并调查冠心病、心力衰竭和中风等亚临床和临床心血管疾病的病因、自然史和进展。因此，ARIC 包括社区监测部分和队列研究部分。 在社区监测方面，对四个社区进行了调查，以确定大约 80 万名 35-84 岁男性和女性住院心肌梗死和冠心病死亡的发生情况。从 2006 年开始，对住院患者（55 岁及以上）和门诊心力衰竭（65 岁及以上）的监测纳入 2005 年开始的事件中。根据新合同，社区监测将继续监测住院心梗、冠心病死亡和心力衰竭（住院患者和门诊患者）的长期趋势。 在队列研究中，通过概率抽样从受监测的四个社区中招募了大约 4,000 名年龄在 45-64 岁之间的个体。 1987 年至 1989 年间，共有 15,792 名参与者（11,478 名白人、4,266 名非裔美国人和 48 名其他人）接受了广泛的基线检查。 1990-92年、1993-95年和1996-98年进行了三次重复检查。检查收集了有关人口统计、心理社会和行为因素、饮食摄入量、身体测量以及生物和遗传标记的信息。根据新合同，幸存的队列成员将接受另一次临床检查，以描述心力衰竭阶段的特征，识别导致心室功能障碍和血管僵硬的遗传和环境因素，并评估肺功能的纵向变化并确定其下降的决定因素。每年还会通过电话联系参与者两次以评估健康状况。 根据新合同，该研究还将通过心血管结果研究得到加强，以评估心力衰竭危险因素和心力衰竭医疗护理的质量和结果。

ARIC is a prospective epidemiologic study conducted in four U.S. communities: Washington County, MD; Forsyth County, NC; Jackson, MS; and Minneapolis, MN. The study is designed to monitor the trends in incidence and mortality of coronary heart disease (CHD) and heart failure in communities, and to investigate the etiology, natural history, and progression of subclinical and clinical cardiovascular disease such as CHD, heart failure, and stroke. Accordingly, ARIC includes a Community Surveillance Component and Cohort Study Component. For the community surveillance, the four communities are investigated to determine the occurrence of hospitalized myocardial infarction and CHD deaths in approximately 800,000 men and women aged 35-84 years. Starting in 2006, surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) is included for the events beginning in 2005. Under the new contract, community surveillance will continue to monitor long-term trends in hospitalized MI, CHD deaths, and heart failure (inpatient and outpatient). For the cohort study, approximately 4,000 individuals aged 45-64 years were recruited by probability sampling from each of the four communities under surveillance. A total of 15,792 participants (11,478 whites, 4,266 African Americans, and 48 other) received an extensive baseline examination in 1987-1989. Three repeat examinations were conducted in 1990-92, 1993-95, and 1996-98. The examinations collected information on demographics, psycho-social and behavioral factors, dietary intakes, physical measurements, and biological and genetic markers. Under the new contract, the surviving cohort members will receive another clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants of its decline. Participants are also contacted twice a year by telephone to assess health status. Under the new contract, the study will also be enhanced with cardiovascular outcomes research to assess quality and outcomes of medical care for heart failure risk factors and heart failure.