A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat

具有抗菌和抗氧化特性的自组装凝胶，用于治疗

• 批准号: 8597978
• 负责人: DAVID J VACHON
• 金额: $ 34.92万
• 依托单位: NOVION TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-20 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597978
• 关键词: Accounting; Acetates; Animal Model; Antibiotics; Antioxidants; Bacteria; Burn injury; Cessation of life; Characteristics; Complex; Complication; Cream; Dermal; Development; Dose; Drug Formulations; Effectiveness; Environment; Erythema; Evaluation; Fibroblasts; Free Radicals; Gel; Glutathione; Goals; Granulation Tissue; Healed; Histocompatibility; Hydrogels; Imagery; In Vitro; Individual; Infection; Inflammation; Light; Lipid Peroxidation; Lipids; Liquid substance; Maintenance; Measurement; Methicillin Resistance; Microbial Biofilms; Modeling; Nature; Ointments; Oxidative Stress; Patients; Performance; Peroxidases; Phase; Preparation; Process; Production; Property; Pseudomonas aeruginosa; Rattus; Reactive Oxygen Species; Reduced Glutathione; Research; Resolution; Running; Sepsis; Silver; Solubility; Solutions; Staphylococcus aureus; Sterile coverings; Sulfadiazine; TNF gene; Technology; Testing; Therapeutic; Thick; Tissues; Topical Antibiotic; Topical agent; Toxic effect; Toxin; Treatment outcome; Work; Wound Healing; antimicrobial; antimicrobial drug; base; biomaterial compatibility; carbene; design; healing; improved; in vivo; innovation; leukocyte activation; microbial; microbicide; novel; pathogen; programs; protein complex; public health relevance; resistant strain; scale up; wound

DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and tested in an infected burn wound model in the rat. Formulation of the silver microbicides will be conducted at different concentrations for evaluation. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver microbicides, determination of antimicrobial capacity, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall oxidative stress. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of these silver microbicide complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds while developing a greater understanding of the mechanisms by which these compounds work.

描述(申请人提供)：三种新型的不带电荷的银杀菌剂已被证明对多种病原体有效，当与谷胱甘肽结合时，被证明能自发形成无定形水凝胶，将被配制成两种不同的软膏配方，并在大鼠感染的烧伤创面模型中进行测试。银微杀菌剂的配方将在不同的浓度下进行评估。拟议研究的主要具体目标包括银系杀菌剂的制备和配方/加工、抗菌能力的测定、细胞相容性以及对 大鼠烧伤感染创面模型。建议治疗的主要目标是：1)消除感染，2)促进愈合，3.减少总的氧化应激。这种创新和合理的局部抗菌治疗方法是建立在几项不同研究的基础上的，这些研究揭示了这些银杀微生物剂复合体有希望的生物适用属性。该项目的最终目标是使一种或多种新型杀微生物剂的开发进入下一阶段，这些新型杀菌剂将用于治疗烧伤创面，同时更好地了解这些化合物的作用机制。