A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat

描述（由申请人提供）：三种新型不带电荷的银杀菌剂已被证明对多种病原体有效，当与谷胱甘肽结合时，已被证明自发形成无定形水凝胶，将被配制成两种不同的软膏配方，并在大鼠感染烧伤伤口模型中进行测试。银杀菌剂的配方将以不同的浓度进行评估。拟议研究的主要具体目标包括银杀菌剂的制备和配方/加工，抗菌能力的测定，细胞相容性和评估

DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and tested in an infected burn wound model in the rat. Formulation of the silver microbicides will be conducted at different concentrations for evaluation. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver microbicides, determination of antimicrobial capacity, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall oxidative stress. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of these silver microbicide complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds while developing a greater understanding of the mechanisms by which these compounds work.