A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat

描述（由申请人提供）：三种新型不带电荷的银杀微生物剂已被证明对多种病原体有效，当与谷胱甘肽组合时，已被证明自发形成无定形水凝胶，将被配制成两种不同的软膏制剂，并在大鼠的感染烧伤模型中进行测试。将在不同浓度下配制银杀微生物剂以进行评价。拟议研究的主要具体目标包括银杀微生物剂的制备和配方/加工，抗菌能力的测定，细胞相容性，以及在 大鼠烧伤创面感染模型。所提出的疗法的主要目的是：1）解决感染，2）改善愈合，和3.减少整体氧化应激。这种创新和合理的局部抗微生物治疗方法是建立在几项不同研究的基础上的，这些研究揭示了这些银杀微生物剂络合物有希望的生物适用属性。该项目的最终目标是使这些新型杀微生物制剂中的一种或多种的下一阶段开发成为可能，这些制剂将用于治疗烧伤创面，同时更好地了解这些化合物的工作机制。

DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and tested in an infected burn wound model in the rat. Formulation of the silver microbicides will be conducted at different concentrations for evaluation. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver microbicides, determination of antimicrobial capacity, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall oxidative stress. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of these silver microbicide complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds while developing a greater understanding of the mechanisms by which these compounds work.