Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes

用新型不带电银卡宾配合物治疗伤口感染

基本信息

  • 批准号:
    8453014
  • 负责人:
  • 金额:
    $ 30万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-20 至 2015-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Three novel uncharged silver carbene microbicides that have been shown to be effective against a wide variety of pathogens will be formulated into two different ointment formulations and tested in an infected healing model in the diabetic rat. Formulation of the silver carbenes into one of either a transparent (gel) wound ointment that will allow viewing of the wound while being treated or an occlusive petrolatum-based ointment that is anticipated to have different moisture retention and drug delivery characteristics that a water-based gel will be carried out. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver carbene antimicrobial agents into an ointment form, chemical and biological characterization, determination of maximum tolerated doses, and evaluation in an infected wound model in the rat. The biological characterization involves the determination of the MIC90 for each compound and evaluation of the toxicity of each compound formulated into an ointment over a two log range starting at a concentration (in the ointment) at the MIC90. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) minimization of inflammation, and 3) encouragement of wound resolution. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bio-applicable attributes of these silver carbene complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal compounds that will be targeted for the treatment of infected chronic wounds and burns while developing a greater understanding of the mechanisms by which these compounds work. PUBLIC HEALTH RELEVANCE: Diabetic foot ulcers are a common type of chronic wound affecting as many as 25% of all diabetics and in many cases diabetics develop infection as a consequence of an impaired inflammatory response. Infection can greatly complicate treatment and outcomes for diabetic foot ulcers with 65% of all patients developing osteomyelitis and amputation in 14-24% of the osteomyelitis group (American Diabetes Association, 1999). Complications associated with foot ulcers account for 20-25% of all hospitalizations costing billions of dollars annually and despite the important medical advances that have been made in the treatment of diabetic foot ulcers in the past fifty years, there remains a significant need for more effective therapies to combat infection and impaired wound healing in this patient population.
描述(由申请人提供):将三种新型不带电荷的银卡宾杀微生物剂配制成两种不同的软膏制剂,并在糖尿病大鼠的感染愈合模型中进行测试,这些杀微生物剂已被证明对多种病原体有效。将银卡宾配制成透明(凝胶)伤口软膏或封闭性凡士林基软膏中的一种,所述透明(凝胶)伤口软膏将允许在治疗时观察伤口,所述封闭性凡士林基软膏预期具有与水基凝胶不同的保湿性和药物递送特性。拟议研究的主要具体目的包括将银卡宾抗菌剂制备和配制/加工成软膏形式、化学和生物学表征、最大耐受剂量的测定以及在大鼠感染伤口模型中的评价。生物学表征包括测定每种化合物的MIC 90,并从MIC 90的浓度(软膏中)开始,在两个对数范围内评价配制成软膏的每种化合物的毒性。所提出的治疗的主要目的是:1)感染消退,2)炎症最小化,和3)促进伤口消退。这种创新和合理的局部抗微生物治疗方法是建立在几项不同研究的基础上的,这些研究揭示了这些银卡宾络合物有希望的生物适用属性。该项目的最终目标是使一种或多种新型杀微生物化合物的下一阶段开发成为可能,这些化合物将用于治疗感染的慢性伤口和烧伤,同时更好地了解这些化合物的工作机制。 公共卫生关系:糖尿病足溃疡是一种常见类型的慢性伤口,影响多达25%的所有糖尿病患者,并且在许多情况下,糖尿病患者由于炎症反应受损而发生感染。感染可使糖尿病足溃疡的治疗和结局大大复杂化,所有患者中有65%发生骨髓炎,骨髓炎组中有14-24%截肢(American Diabetes Association,1999)。与足部溃疡相关的并发症占每年花费数十亿美元的所有住院治疗的20-25%,并且尽管在过去五十年中在糖尿病足部溃疡的治疗中已经取得了重要的医学进步,但是仍然存在对糖尿病足部溃疡的显著需求。 更有效的治疗来对抗感染和该患者群体中受损的伤口愈合。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DAVID J VACHON其他文献

DAVID J VACHON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DAVID J VACHON', 18)}}的其他基金

A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat
具有抗菌和抗氧化特性的自组装凝胶,用于治疗
  • 批准号:
    8597978
  • 财政年份:
    2013
  • 资助金额:
    $ 30万
  • 项目类别:
A Novel Electrospun Vascular Graft
新型静电纺血管移植物
  • 批准号:
    7805685
  • 财政年份:
    2010
  • 资助金额:
    $ 30万
  • 项目类别:
Peptide-Modified Sulfonated Styrene Block Copolymers for Vascular Applications
用于血管应用的肽改性磺化苯乙烯嵌段共聚物
  • 批准号:
    7393608
  • 财政年份:
    2008
  • 资助金额:
    $ 30万
  • 项目类别:
Topical Modulation of Burn Wound Healing
烧伤伤口愈合的局部调节
  • 批准号:
    7481972
  • 财政年份:
    2008
  • 资助金额:
    $ 30万
  • 项目类别:
A Novel & Tailorable Drug Delivery Device for the Treatment of Periodontitis
一本小说
  • 批准号:
    7537768
  • 财政年份:
    2008
  • 资助金额:
    $ 30万
  • 项目类别:
A Novel & Tailorable Topical Wound Therapy Based on a Semi-Interpenetrating Polym
一本小说
  • 批准号:
    7275122
  • 财政年份:
    2007
  • 资助金额:
    $ 30万
  • 项目类别:
PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERS
用于治疗静脉溃疡的蛋白酶调节伤口敷料
  • 批准号:
    6998556
  • 财政年份:
    2006
  • 资助金额:
    $ 30万
  • 项目类别:
Synthesis and Processing of Sulfonated Block Copolymer Biomaterials
磺化嵌段共聚物生物材料的合成与加工
  • 批准号:
    7109992
  • 财政年份:
    2006
  • 资助金额:
    $ 30万
  • 项目类别:
Novel Cation-Exchange Wound Dressing for Diabetic Ulcers
用于糖尿病溃疡的新型阳离子交换伤口敷料
  • 批准号:
    6834243
  • 财政年份:
    2004
  • 资助金额:
    $ 30万
  • 项目类别:
Novel Wound Dressing for Chronic Ulcers
用于慢性溃疡的新型伤口敷料
  • 批准号:
    6550024
  • 财政年份:
    2002
  • 资助金额:
    $ 30万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 30万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了