How social challenges prime the brain and body for social instability

社会挑战如何使大脑和身体做好应对社会不稳定的准备

基本信息

  • 批准号:
    8505525
  • 负责人:
  • 金额:
    $ 18.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-08-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Social competition is ubiquitous in both animal and human life, and the threat from a competitor typically induces a systemic surge in the steroid hormone testosterone. While past research demonstrates clear connections among social challenges, testosterone and a suite of physiological and behavioral effects, the molecular mechanisms underlying these phenotypic changes are poorly understood. Generating an appropriate organismal response to social challenges requires large scale coordination of behavior and physiology (e.g. changes in aggression, pain tolerance, and metabolism), yet the transcriptomic mechanisms by which brain and body act together to produce a coordinated response to social challenges are unclear. The long-term goal of the proposed research is to determine how steroid hormones serve to link brain and periphery in genomic and behavioral responses to environmental contingencies. The working hypothesis is that social challenges, and their associated testosterone surges, prime individuals for success in future competition, favoring greater mobilization of energy reserves, heightened response to injury or inflammation, and greater spatial and sensory capabilities, all at the expense of self-maintenance. The objectives of this particular application are to identify how gene transcription is altered by aggressive social interactions, and to characterize how the environmental effects of a social challenge differ in brain and periphery, while engendering a coordinated organismal response to social instability. The subject is a well-studied songbird in which social challenges lead to a systemic surge in testosterone, and the effects of testosterone on many aspects of behavior and physiology are well characterized (aggression, immune function, stress, activity, etc.). By employing emerging genomic techniques, including gene set enrichment and network co-expression analyses, the proposed research will identify the effects of (1) acute social challenges and (2) persistent social instability on gene transcription, relative to unchallenged control animals. These data will reveal gene families, hubs of connectivity within gene networks, and neural and peripheral tissues that are particularly prone to socially induced plasticity. Patterns of co-variation among tissues will further reveal the precise molecular mechanisms by which social challenges prime the brain and body for a coordinated response to social instability. Knowledge of how social stressors derail normal healthy organismal function can be applied to a range of hormonally and socially induced human health issues (e.g. reproductive health, behavioral disorders of high aggression, etc.), where insights to be gained by co-discussion of social environment, brain, and periphery have yet to be fully realized.
描述(由申请人提供):社会竞争在动物和人类生活中无处不在,来自竞争对手的威胁通常会引起类固醇激素睾酮的全身性激增。虽然过去的研究表明社会挑战,睾酮和一系列生理和行为影响之间存在明确的联系,但这些表型变化背后的分子机制却知之甚少。对社会挑战产生适当的生物反应需要大规模的行为和生理协调(例如攻击性,疼痛耐受性和代谢的变化),但大脑和身体共同作用以产生对社会挑战的协调反应的转录组学机制尚不清楚。这项研究的长期目标是确定类固醇激素如何在基因组和行为反应中将大脑和外周联系起来,以应对环境突发事件。工作假设是,社会挑战,以及与之相关的睾丸激素激增,为个体在未来的竞争中取得成功做好准备,有利于更好地调动能量储备,提高对损伤或炎症的反应,以及更大的空间和感官能力,所有这些都以自我维护为代价。这个特殊的应用程序的目标是确定基因转录是如何被积极的社会互动改变,并表征如何在大脑和外周的社会挑战的环境影响不同,同时产生一个协调的有机体对社会不稳定的反应。该主题是一种经过充分研究的鸣禽,其中社会挑战导致睾酮的系统性激增,并且睾酮对行为和生理学的许多方面的影响得到了很好的表征(攻击性,免疫功能,压力,活动等)。通过采用新兴的基因组技术,包括基因集富集和网络共表达分析,拟议的研究将确定(1)急性社会挑战和(2)相对于未受挑战的对照动物,持续的社会不稳定对基因转录的影响。这些数据将揭示基因家族,基因网络内的连接枢纽,以及特别容易受到社会诱导的可塑性的神经和外周组织。组织间的共同变异模式将进一步揭示社会挑战促使大脑和身体对社会不稳定做出协调反应的精确分子机制。关于社会压力如何破坏正常健康生物体功能的知识可以应用于一系列由生殖和社会引起的人类健康问题(例如生殖健康、高攻击性行为障碍等),通过共同讨论社会环境、大脑和周边获得的见解尚未完全实现。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Behavioral effects of social challenges and genomic mechanisms of social priming: What's testosterone got to do with it?
社会挑战的行为影响和社会启动的基因组机制:睾酮与它有什么关系?
  • DOI:
    10.1093/czoolo/60.6.791
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Rosvall,KimberlyA;Peterson,MarkP
  • 通讯作者:
    Peterson,MarkP
Proximate perspectives on the evolution of female aggression: good for the gander, good for the goose?
The effect of chronic and acute stressors, and their interaction, on testes function: an experimental test during testicular recrudescence.
慢性和急性应激源及其相互作用对睾丸功能的影响:睾丸复发期间的实验测试。
  • DOI:
    10.1242/jeb.180869
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Abolins-Abols,Mikus;Hanauer,RachelE;Rosvall,KimberlyA;Peterson,MarkP;Ketterson,EllenD
  • 通讯作者:
    Ketterson,EllenD
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Kimberly Anne Rosvall其他文献

Kimberly Anne Rosvall的其他文献

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{{ truncateString('Kimberly Anne Rosvall', 18)}}的其他基金

How social challenges prime the brain and body for social instability
社会挑战如何使大脑和身体做好应对社会不稳定的准备
  • 批准号:
    8356420
  • 财政年份:
    2012
  • 资助金额:
    $ 18.51万
  • 项目类别:
Integration and independence of neuroendocrine mechanisms of behavior
行为神经内分泌机制的整合和独立
  • 批准号:
    8201421
  • 财政年份:
    2011
  • 资助金额:
    $ 18.51万
  • 项目类别:

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