Transdiagnostic psychiatric symptoms related to visual processing abnormalities

与视觉处理异常相关的跨诊断精神症状

• 批准号: 8434418
• 负责人: Jeffrey S. Bedwell
• 金额: $ 40.4万
• 依托单位: UNIVERSITY OF CENTRAL FLORIDA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-08 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8434418
• 关键词: Academic Research Enhancement Awards; Address; Affect; Anxiety; Applications Grants; Area; Attention; Auditory; Award; Behavior; Belief; Bipolar Disorder; Brain; Categories; Chronic; Clinical; Cognitive; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Diffuse; Dimensions; Disease; Early identification; Electroencephalography; Environment; Etiology; First Degree Relative; Florida; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Generations; Goals; Human Resources; Individual; Institution; Intervention; Investigation; Label; Light; Literature; Mental disorders; National Institute of Mental Health; Neurobiology; Neurocognitive Deficit; Pathway interactions; Patient Self-Report; Patients; Pattern; Performance; Pilot Projects; Population; Prevention program; Primates; Research; Research Personnel; Research Training; Sampling; Schizophrenia; Sensory; Short-Term Memory; Staging; Students; Subgroup; Symptoms; Thinking; Training; United States; United States National Institutes of Health; Universities; Visual; Visual Pathways; Visual evoked cortical potential; Work; base; effective therapy; experience; graduate student; interest; intervention program; magnocellular; neurobehavioral; neuropathology; parvocellular; patient population; public health relevance; severe mental illness; social; undergraduate student; visual process; visual processing

DESCRIPTION (provided by applicant): Schizophrenia is a chronic, severe, mental illness, with over 2.5 million individuals estimated to have this disorder in the United States alone. Schizophrenia has been associated with a large number of neurocognitive deficits that researchers have investigated to better understand the underlying etiology and subtypes. One deficit that has received considerable attention is dysfunction in early visual processing, which has been assessed with visual-evoked potentials (VEPs) using electroencephalography. Most VEP studies have suggested a hypoactive magnocellular (M) visual pathway in individuals with schizophrenia, while a smaller number of studies have suggested that the parvocellular (P) pathway may also be hypoactive. A separate line of investigation has demonstrated that a subset of individuals with schizophrenia show an abnormal change in visual processing to red light. Despite the existing research on these visual processing abnormalities in schizophrenia samples, they remain poorly understood in terms of related symptom profiles and neurobiological etiologies. To address this need, the proposed 3-year project will assess 100 individuals with a broad range of schizophrenia-related disorders and 100 controls. The study will use a comprehensive diagnostic and symptom assessment (both self-reported and clinician administered) along with a VEP task to examine the relationship of the early visual processing abnormalities with clusters of schizophrenia-related symptoms. We expect that the VEP-to-symptom relationships will be stronger when examined across the diagnostic boundaries of the schizophrenia-related disorders rather than within particular diagnoses. VEPs will be elicited using a repeated transient (60 ms) presentation of a checkered pattern (presented at either high or low contrast) on alternating green and red backgrounds. We will examine whether there are specific differential clusters of schizophrenia-related symptoms that relate to VEP abnormalities of interest (which includes the abnormal change to red light). In addition, we will examine how each VEP abnormality relates to visual and auditory working memory performance. The results from this study will have strong potential to increase our understanding the underlying neuropathology and etiology of the schizophrenias that likely underlie our unitary concept of schizophrenia. This could potentially uncover new clinically-meaningful diagnostic categories, thereby facilitating the search for more effective pharmacological interventions for this devastating condition. Early identification of these deficits could also set the stage for intervention or prevention programs to ameliorate the most impairing aspects of this disorder.

描述（由申请人提供）：精神分裂症是一种慢性，严重，精神疾病，仅在美国就有超过250万人患有这种疾病。精神分裂症与研究人员所研究的大量神经认知缺陷有关，以更好地了解潜在的病因和亚型。在早期视觉处理中，引起了很大关注的赤字是功能障碍，该障碍已通过脑电图用视觉诱发电位（VEP）进行评估。大多数VEP研究表明，精神分裂症患者的低连接性大细胞（M）视觉途径，而较少的研究表明，副细胞（P）途径也可能是低连接性的。单独的调查线表明，精神分裂症患者的一部分表明，视觉处理为红光的异常变化。尽管现有关于精神分裂症样本中这些视觉加工异常的研究，但在相关症状特征和神经生物学病因方面，它们仍然对它们保持不足。为了满足这一需求，拟议的3年项目将评估100名与精神分裂症相关疾病和100个对照的人。该研究将使用全面的诊断和症状评估（均已自我报告和临床医生）以及VEP任务，以检查早期视觉处理异常与精神分裂症相关症状簇的关系。我们预计，在精神分裂症相关疾病的诊断边界中检查而不是在特定诊断中，对VEP到症状的关系将更加牢固。 VEP将通过在交替的绿色和红色背景上的重复瞬态（60 ms）表示（在高或低对比度）中引起VEP。我们将研究是否存在与感兴趣的VEP异常相关的精神分裂症相关症状的特定差分簇（包括与红光的异常变化）。此外，我们将研究每个VEP异常与视觉和听觉工作记忆性能的关系。这项研究的结果将具有强大的潜力，可以提高我们理解精神分裂症的基本神经病理学和病因，这可能是我们精神分裂症的单一概念的基础。这可能会揭示新的临床诊断类别，从而促进为这种毁灭性疾病寻找更有效的药理干预措施。这些缺陷的早期识别也可能为干预或预防计划奠定了基础，以改善该疾病最受损的方面。