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Growth Factors and Memory Formation

生长因子和记忆形成

基本信息

批准号：
8496122
负责人：
Thomas J Carew
金额：
$ 36.41万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8496122
关键词：
Accidents Address Adult Alzheimer&apos s Disease Aplysia Behavioral Binding Biological Models Brain Clinical Cognition Disorders Cognitive Data Development Developmental Process Disease Event Extracellular Protein Family Goals Growth Factor Health Individual Injury Knowledge Learning Link Maintenance Marines Mediating Memory Memory impairment Mental Health Mission Molecular Motor National Institute of Mental Health Neurodegenerative Disorders Neurons Neurosciences Outcome Phase Play Post-Traumatic Stress Disorders Preparation Publishing Research Project Grants Research Proposals Role Seminal Sensory Services Signal Transduction Stroke Synapses Synaptic plasticity System Testing Therapeutic Agents Time Training base effective therapy forging long term memory memory process molecular dynamics neuronal cell body neurotrophic factor novel novel strategies receptor research study spatiotemporal therapeutic target

项目摘要

DESCRIPTION (provided by applicant): One of the greatest challenges in modern neuroscience is to achieve an understanding of how the brain acquires, stores and retrieves information. A particularly exciting new development in exploring this general question is the recent identification of the possible role of growth factors, once considered to function mainly in brain development, in synaptic plasticity and memory in the adult. While this idea is truly seminal, a causal role of growth factors in memory formation has yet to be established. Thus the broad, long-term goal of this research project is to elucidate in mechanistic detail the ways in which growth factors participate in the formation and maintenance of long-term memories. To achieve this goal we will explore two interrelated Specific Aims. In AIM 1 we will test the hypothesis that growth factor signaling plays an essential role in memory formation and its underlying synaptic plasticity, and in Aim 2 we will test the hypothesis that growth factors re-employ molecular signaling cascades originally engaged in development in the service of adult memory formation and synaptic plasticity. Of direct relevance to the health-related mission of the NIMH, these two Aims will address a major challenge in mental health: to achieve a basic understanding of the brain mechanisms that are engaged in normal memory formation, and how those mechanisms are impaired when memory is compromised by disease or injury. Thus, understanding the molecular mechanisms whereby growth factors contribute to normal memory formation can provide an important and novel means of identifying therapeutic targets for a variety of health related cognitive disorders. To directly explore how growth factors participate i memory formation requires multiple levels of analysis (behavioral, cellular, synaptic, and molecular levels). Aplysia californica is a powerful model system to address this question because it allows such a simultaneous multi-level analysis, as well as a time-dependent analysis of when critical changes occur, and a spatial analysis of where changes occur in different regions of individual neurons. Thus a unique feature of this proposal is our use of a system that has the potential to demonstrate causal linkages between growth factor-mediated memory formation and the temporal and spatial features of the underlying synaptic mechanisms.

描述（由申请人提供）：现代神经科学最大的挑战之一是理解大脑如何获取、存储和检索信息。在探索这一一般性问题方面，一个特别令人兴奋的新进展是，最近发现了生长因子的可能作用，而生长因子曾被认为主要作用于