Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
基本信息
- 批准号:8447542
- 负责人:
- 金额:$ 37.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2015-03-31
- 项目状态:已结题
- 来源:
- 关键词:12 year oldAddressAffectAgeAmygdaloid structureAngerAnteriorAnxietyAnxiety DisordersAttentionBehaviorBehavior TherapyBehavioralBrainBrain imagingBuild-itChildChildhoodClinicalCognitionCognitive deficitsCollaborationsComorbidityConflict (Psychology)Corpus striatum structureDataDevelopmentDiffusion Magnetic Resonance ImagingDimensionsDiseaseDorsalEmotionalEmotionsEquilibriumFaceFunctional Magnetic Resonance ImagingFunctional disorderGenderGoalsHeterogeneityImpulsivityIndividualIndividual DifferencesKnowledgeMediatingMethodsModelingNeuroanatomyParietalPharmacological TreatmentPrefrontal CortexProcessPsychopathologyResearchResolutionRestScanningServicesSeveritiesStimulusSymptomsTestingVariantautism spectrum disordercognitive functioncognitive neuroscienceexecutive functioninformation processingneuroimagingnovelnovel strategiesoperationresponsesocialtheoriestraitwhite matter
项目摘要
ABSTRACT
Autism Spectrum Disorder (ASD) is characterized by pervasive socio-emotional and cognitive deficits even in
children with high intellectual function. Its neuropathophysiology involves executive dysfunction mediated by
prefrontal cortex but is not well-understood, due to high phenotypic heterogeneity and comorbidity with
attention and anxiety disorders and a lack of resolution in affected component processes of executive function.
We postulate that symptom expression varies among ASD children due to the influence of traits that
characterize comorbid disorders (impulsivity, anxiety). Examining differences in functional brain organization
of executive control due to anxiety and impulsivity with sensitive fMRI probes will elucidate phenotypic
heterogeneity in ASD children. Guided by developmental neuroanatomical models, we will examine
multiple top-down control processes and bottom-up perceptual processes that function in adaptive
balance to serve goal-directed behavior. We will test the hypothesis that specific prefrontal-striato-
limbic circuits, which mediate that adaptive balance, are atypical in ASD. We will manipulate component
operations of top-down (voluntary, involuntary) and bottom-up (attention bias to salience) processing in 9-12
year-old high-functioning ASD children and age, Verbal IQ, and gender matched controls. Group differences
and individual variation by anxiety, impulsivity, and symptom severity will be examined with confirmatory
(hypothesis-driven) and exploratory (data-driven) analysis of functional networks and underlying white-matter
microstructure. Aim I examines whether voluntary and involuntary control of attention is modulated by
stimulus saliency (i.e., perceptual novelty, emotion) atypically in ASD. Exp 1 will examine incidental
(involuntary) and intentional (voluntary) encoding of salient (novel/infrequent vs. familiar/repeated) distracters
in the context of an ongoing task. Exp 2 will examine exogenous (involuntary) and endogenous (voluntary)
attentional bias to salient faces (angry vs. neutral) in the Dot-probe task. Aim 2 examines whether voluntary
and involuntary control of responses is modulated by stimulus domain (social-emotional or non-
social) atypically in ASD. Exp 3 will examine voluntary response control (response inhibition and
interference suppression) and involuntary context adaptation during a Flanker task with symbolic (non-social)
stimuli. Exp 4 will examine voluntary response control during conflict varying in socio-emotional significance in
a Stroop-like task. Aim 3 will examine whether intrinsic resting-state connectivity is atypical in ASD.
Current research shows parallel functional organization during behavioral and resting states. We will search
for resting-state correlates of component operations of executive control pooled by voluntary and involuntary
conditions and domains (non-social, socio-emotional) from Exps 1-4 and determine whether they are atypical
in ASD and vary by anxiety, impulsivity, and symptom severity. New knowledge from this proposal will refine
models of ASD neuropathophysiology and provide targets for pharmacological and behavioral intervention.
摘要
自闭症谱系障碍(ASD)的特点是普遍的社会情感和认知缺陷,即使在
高智力功能的儿童。其神经病理生理学涉及执行功能障碍,
前额叶皮层,但由于高表型异质性和共病,
注意力和焦虑障碍以及执行功能的受影响组件过程中缺乏解决方案。
我们假设,ASD儿童的症状表现不同,这是由于以下特征的影响,
表征共病障碍(冲动、焦虑)。检查大脑功能组织的差异
执行控制由于焦虑和冲动与敏感的功能磁共振成像探针将阐明表型
ASD儿童的异质性。在发育神经解剖学模型的指导下,我们将研究
多个自上而下的控制过程和自下而上的感知过程,
平衡以服务于目标导向的行为。我们将检验特定的前额叶纹状体-
调节适应性平衡边缘回路在ASD中是非典型的。我们将操纵组件
自上而下(自愿,非自愿)和自下而上(注意力偏向于显著性)的加工操作9-12
岁的高功能ASD儿童和年龄,言语智商和性别匹配的对照。群体差异
焦虑、冲动和症状严重程度的个体差异将用确证性
(假设驱动)和探索性(数据驱动)分析功能网络和潜在的白质
微观结构目的I检验注意力的自愿和非自愿控制是否受到
刺激显著性(即,知觉新奇感、情感)在ASD中的作用。实验1将检查附带的
(非自愿)和有意(自愿)编码的显着(新的/不常见的与熟悉/重复)干扰
在一个正在进行的任务的背景下。实验2将检查外源性(非自愿)和内源性(自愿)
点探测任务中对显著面孔(愤怒与中性)的注意偏向。目标2审查是否自愿
和无意识控制的反应是调制的刺激域(社会情绪或非-
在ASD中的社会性。实验3将检查自愿反应控制(反应抑制和
干扰抑制)和无意识的上下文适应过程中的侧卫任务与符号(非社会)
刺激。实验4将考察冲突中的自愿反应控制在社会情感意义上的变化,
一个类似Stroop的任务。目的3将研究是否内在的静息状态连接是非典型的ASD。
目前的研究表明,在行为和静息状态下的平行功能组织。我们会搜查
对于由自愿和非自愿汇集的执行控制的组件操作的静息状态相关性,
条件和领域(非社会,社会情感)从实验1-4,并确定他们是否是非典型的
在ASD中,并因焦虑、冲动和症状严重程度而异。这项提案中的新知识将使
ASD神经病理生理学模型,并提供药理学和行为干预的目标。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Atypical Functional Connectivity of the Amygdala in Childhood Autism Spectrum Disorders during Spontaneous Attention to Eye-Gaze.
- DOI:10.1155/2012/652408
- 发表时间:2012-01-01
- 期刊:
- 影响因子:0
- 作者:Murphy, Eric R;Foss-Feig, Jennifer;Vaidya, Chandan J
- 通讯作者:Vaidya, Chandan J
Neural basis of implicit memory for socio-emotional information in schizophrenia.
- DOI:10.1016/j.psychres.2012.10.005
- 发表时间:2013-04-30
- 期刊:
- 影响因子:11.3
- 作者:Schwartz, Barbara L.;Vaidya, Chandan J.;Shook, Devon;Deutsch, Stephen I.
- 通讯作者:Deutsch, Stephen I.
Neurodevelopmental abnormalities in ADHD.
- DOI:10.1007/7854_2011_138
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Vaidya, Chandan J
- 通讯作者:Vaidya, Chandan J
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Chandan J Vaidya其他文献
Chandan J Vaidya的其他文献
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{{ truncateString('Chandan J Vaidya', 18)}}的其他基金
Effects of dopaminergic genotypes on resting state connectivity relevant to execu
多巴胺能基因型对与执行相关的静息态连接的影响
- 批准号:
8062272 - 财政年份:2010
- 资助金额:
$ 37.18万 - 项目类别:
Effects of dopaminergic genotypes on resting state connectivity relevant to execu
多巴胺能基因型对与执行相关的静息态连接的影响
- 批准号:
7896266 - 财政年份:2010
- 资助金额:
$ 37.18万 - 项目类别:
Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
- 批准号:
8478835 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
- 批准号:
8235038 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
- 批准号:
8045413 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
FUNCTIONAL MRI OF ATTENTION REGULATION IN PEOPLE WITH AND WITHOUT AUTISM
自闭症患者和非自闭症患者注意力调节的功能性 MRI
- 批准号:
7951969 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
- 批准号:
7731942 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
Neuroimaging of Top-Down Control and Bottom-Up Processes in Childhood ASD
儿童自闭症谱系障碍自上而下控制和自下而上过程的神经影像学
- 批准号:
7874721 - 财政年份:2009
- 资助金额:
$ 37.18万 - 项目类别:
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