Steroid Catecholamine Interactions and Behavior

类固醇儿茶酚胺相互作用和行为

基本信息

  • 批准号:
    8594014
  • 负责人:
  • 金额:
    $ 35.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1993
  • 资助国家:
    美国
  • 起止时间:
    1993-07-01 至 2018-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The regulation of social interactions is of fundamental importance to both basic scientists and to clinicians interested in the etiology of mental illness. Such studies can produce general principles that will facilitate insights into the etiology and pathophysiology of mental disorders. This endeavor is a major goal of the NIMH and of this research program. The activation of social behaviors involves not only an individual being in the presence of an appropriate stimulus but also being in the appropriate motivational state. The steroid hormone testosterone is a pro-hormone that can be metabolized via the enzyme aromatase to an estrogen such as estradiol. In the preoptic area, the conversion of testosterone to estradiol is critical for the activation of both sexual motivation and performance. Estradiol ca act in two modes, a slow mode that involves binding to intracellular receptors and the induction of gene expression and a fast mode that involves interactions with the cell membrane and the activation of second messenger systems. Our recent work has shown that the fast actions of estrogens produced by brain aromatase are important for the activation of appetitive sexual behavior (motivational aspects) while the slower genomic actions are important for the activation of copulatory performance. In addition to the preoptic area, aromatase is widely distributed in brain nuclei of the social behavior network. One goal of the current proposal (Aim I) is to investigate in both males and females the function of estrogen production in other nuclei of the social behavior network besides the preoptic area and the effects of estrogens on motivational aspects of other social behaviors besides sexual behavior. Another goal (Aim II) is to study the rapid non-genomic effects of steroid hormones on male sexual motivation and whether these effects are specific to sexual motivation or extend to other motivated responses. We will also assess the neuroanatomical target sites of these effects. Subsequent studies in Aim III will address some the cellular mechanisms of these effects. For example, there is evidence that estrogen receptors embedded in the cell membrane interact with receptors for the excitatory amino acid receptor glutamate. The anatomical pattern of such interactions and the role they play in motivation will be investigated. Finally in the last aim (IV) the rapid regulation of the enzyme, aromatase, that converts androgens to estrogens will be studied. We will assess how behavioral situations that modulate motivation might also modulate aromatase that in turn will affect how much estradiol is available in specific brain areas related to behavioral activation.
描述(由申请人提供):社会互动的调节对基础科学家和对精神疾病病因感兴趣的临床医生都至关重要。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Gregory F Ball其他文献

Mechanistic target of rapamycin (mTOR): A mediator of social development
25 – Neuroendocrine Regulation of Reproductive Behavior in Birds
25 – 鸟类繁殖行为的神经内分泌调节
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gregory F Ball
  • 通讯作者:
    Gregory F Ball
Physicochemical analytical techniques (excluding HPLC).
理化分析技术(不包括HPLC)。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gregory F Ball
  • 通讯作者:
    Gregory F Ball
Prior Experience with Photostimulation Enhances Photo-Induced Reproductive Development in Female European Starlings: A Possible Basis for the Age-Related Increase in Avian Reproductive Performance1
先前的光刺激经验增强了雌性欧洲八哥的光诱导生殖发育:鸟类生殖性能与年龄相关的增长的可能基础1
  • DOI:
    10.1095/biolreprod.104.029751
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Keith W. Sockman;T. Williams;A. Dawson;Gregory F Ball
  • 通讯作者:
    Gregory F Ball
Anatomical relationships between aromatase and tyrosine hydroxylase in the quail brain: Double‐label immunocytochemical studies
鹌鹑脑中芳香酶和酪氨酸羟化酶之间的解剖关系:双标记免疫细胞化学研究
  • DOI:
    10.1002/(sici)1096-9861(19980209)391:2<214::aid-cne5>3.0.co;2-5
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    J. Balthazart;A. Foidart;M. Baillien;N. Harada;Gregory F Ball
  • 通讯作者:
    Gregory F Ball

Gregory F Ball的其他文献

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{{ truncateString('Gregory F Ball', 18)}}的其他基金

Steroid Hormone Regulation of Brain Plasticity and Vocal Behavior
类固醇激素对大脑可塑性和声音行为的调节
  • 批准号:
    10350677
  • 财政年份:
    2018
  • 资助金额:
    $ 35.55万
  • 项目类别:
Steroid Hormone Regulation of Brain Plasticity and Vocal Behavior
类固醇激素对大脑可塑性和声音行为的调节
  • 批准号:
    9886292
  • 财政年份:
    2018
  • 资助金额:
    $ 35.55万
  • 项目类别:
NEUROCHEMICAL MARKERS OF SEXUALLY DIMORPHIC NUCLEI IN AVIAN VOCAL CONTROL SYSTEM
鸟类声音控制系统中性二态核的神经化学标记
  • 批准号:
    6336888
  • 财政年份:
    1998
  • 资助金额:
    $ 35.55万
  • 项目类别:
Seasonal Plasticity in Steroid-Sensitive Neural Circuits
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    6750644
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
Seasonal Plasticity in Steroid-Sensitive Neural Circuits
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    7245136
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
NEUROCHEMICAL MARKERS OF SEXUALLY DIMORPHIC NUCLEI IN AVIAN VOCAL CONTROL SYSTEM
鸟类声音控制系统中性二态核的神经化学标记
  • 批准号:
    6251551
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
Seasonal Plasticity in Steroid-Sensitive Neural Circuits
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    6909908
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
Seasonal Plasticity in Steroid-Sensitive Neural Circuits
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    6684635
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
Seasonal Plasticity in Steroid-Sensitive Neural Circuits
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    7655207
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:
SEASONAL PLASTICITY IN STEROID SENSITIVE NEURAL CIRCUITS
类固醇敏感神经回路的季节性可塑性
  • 批准号:
    6187315
  • 财政年份:
    1997
  • 资助金额:
    $ 35.55万
  • 项目类别:

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