开发统计方法来检测人类谱系中的罕见遗传变异-猫眼课题宝

开发统计方法来检测人类谱系中的罕见遗传变异

批准号：

8745754

负责人：

Yin Yao

金额：

$34.76万

依托单位：

NATIONAL INSTITUTE OF MENTAL HEALTH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8745754

关键词：

Accounting Affect Algorithms Amish Base Sequence Code Communities Complex Coupled DNA Data Data Set Dependency Development Disease Disease model Family Future Genes Genetic Genomics Haplotypes Human Human Genetics Individual Intramural Research Program Literature Machine Learning Mental disorders Methods Modeling Mutation Nasopharynx Carcinoma Obsessive-Compulsive Disorder Phenotype Population Property Publications Relative (related person)Research Design Role Schizophrenia Scientist Sequence Analysis Statistical Methods Sum Technology Testing Variant Weight Work analytical method base database of Genotypes and Phenotypes design exome sequencing family structure genetic linkage analysis genetic pedigree genetic variant genome sequencing genome wide association study human disease interest large scale simulation next generation sequencing novel population based statistics trait

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英文摘要

We have developed pedigree-based rare variants analysis approach by treating each affected relatives as dependent pairs and the dependency will be accounted for using correlation matrix. This work led to two publications. We are now working on using a haplotype-based approach to identify causal variants for human diseases such as schizophrenia, bipolar and obsessive compulsive disorder. We have obtained the relevant data sets from dbGap which will allow us to compare the statistical properties (in an empirical sense) given by various types of analytical methods. In the future, we will also make contribution to a bipolar study in the Plain People in the Amish community, led by Dr. Francis McMahon (Chief, Human Genetics Branch, Intramural Research Program).

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