An Integrated CT-based Image-Guided Neurosurgical System

基于 CT 的集成图像引导神经外科系统

• 批准号: 8833522
• 负责人: William Charles VanKampen
• 金额: $ 90.15万
• 依托单位: XORAN TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8833522
• 关键词: Integrated; CT; based; Image; Guided

DESCRIPTION (provided by applicant): Recent advances in x-ray detectors and microcomputers have enabled compact and affordable computed tomography (CT) imaging devices to be successful in dental and otolaryngology applications. This technology holds promise for neurosurgical applications. Specifically, intraoperative imaging updates would benefit minimally-invasive treatment of brain cancer by providing anatomic updates to the surgeon and localization data updates to surgical navigation for more accurate, safe and complete neoplasm removal. In this project, a compact intra-operative flat-panel CT imager integrated with a surgical navigation system will be developed. The product will use advanced imaging methods to produce low-artifact soft tissue images, even in the skull base and posterior fossa, which are typically challenging regions for x-ray imagers. The product will offer soft tissue image quality unprecedented for x-ray based surgical navigation. It will also be the most compact and OR-friendly image-guided neurosurgical navigation system available to date. Phase 1 work demonstrated the feasibility of using flat panel cone beam CT for low contrast imaging, as required for neurosurgical applications. In Phase 2, further efforts are proposed to advance soft-tissue imaging capability and to integrate the imager with surgical navigation tools. A prototype will be evaluated in a pilot study for the specific minimally-invasive neurosurgical task of transphenoidal endonasal pituitary tumor resection surgery. If successful, approximately $13 M in annual revenue and 15 additional jobs will be generated in the southeast Michigan life sciences corridor.

描述（由申请人提供）：X射线探测器和微型计算机的最新进展使得紧凑且经济实惠的计算机断层扫描（CT）成像设备在牙科和耳鼻喉科应用中获得成功。这项技术有望用于神经外科应用。具体而言，术中成像更新将通过向外科医生提供解剖学更新和向手术导航提供定位数据更新以实现更准确、安全和完整的肿瘤切除而有利于脑癌的微创治疗。在本项目中，将开发一种与手术导航系统集成的紧凑型术中平板CT成像仪。该产品将使用先进的成像方法来产生低伪影的软组织图像，即使在颅底和后颅窝，这是典型的X射线成像仪的挑战区域。该产品将为基于X射线的手术导航提供前所未有的软组织图像质量。它也将是迄今为止最紧凑和最友好的图像引导神经外科导航系统。第1阶段的工作证明了使用平板锥形束CT进行神经外科应用所需的低对比度成像的可行性。在第2阶段，提出了进一步的努力，以提高软组织成像能力，并将成像仪与手术导航工具。原型将在一项试点研究中进行评估，用于经蝶窦鼻内垂体瘤切除术的特定微创神经外科任务。如果成功，密歇根州东南部生命科学走廊将产生约1300万美元的年收入和15个额外的工作岗位。