Basic Research Support for the CCR

CCR的基础研究支持

• 批准号: 8763746
• 负责人: Robert Wiltrout
• 金额: $ 85.03万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763746
• 关键词: Acquired Immunodeficiency Syndrome; Algorithms; Animal Technicians; Apoptotic; Area; Autoimmune Diseases; Basic Science; Biological Assay; Biology; Breast; Cancer Research Project; Cell Death; Cell Lineage; Cell Survival; Cell physiology; Cell surface; Chemicals; Chemistry; Clinical; Communicable Diseases; Contrast Media; Dendritic Cells; Development; Disease; Drug Delivery Systems; Drug resistance; Effector Cell; Embryonic Development; Epigenetic Process; Event; Genetic; Glioma; Glycobiology; Growth; HIV; HLA Antigens; Hematopoiesis; Human Resources; Immune response; Immunobiology; Immunogenetics; Immunotherapy; Inflammation; Information Technology; Interleukin-7; Laboratories; Laboratory Animals; Laboratory Research; MHC Class II Genes; Malignant Neoplasms; Medical Imaging; Molecular; Molecular Biology; Molecular Models; Molecular Target; Mus; NCI Center for Cancer Research; Natural Products Chemistry; Neoplasm Metastasis; Nitric Oxide; Pathway interactions; Pattern; Play; Predisposition; Prevention therapy; Prostate; Protein Chemistry; Proteins; Qualifying; Reaction; Regulation; Renal Cell Carcinoma; Renal carcinoma; Research; Research Support; Resistance; Role; Scientist; Stem cells; Structure; Susceptibility Gene; T-Lymphocyte and Natural Killer Cell; Technical Expertise; Urologic Oncology; Vaccines; anticancer research; base; cancer diagnosis; cancer genetics; cancer prevention; cancer stem cell; cancer therapy; carcinogenesis; cell type; cellular imaging; cytokine; glycosyltransferase; member; molecular modeling; multidisciplinary; nanobiology; novel; programs; protein protein interaction; screening; self-renewal; stem cell biology; structural biology; tumor; tumorigenesis

The Basic Research Program (BRP) provides scientific and technical expertise to NCI's Center for Cancer Research (CCR) in areas ranging from cancer and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), to the basic cellular processes underlying cancer, infectious diseases, and autoimmune disorders. Research topics supported by the BRP include: -Investigating ways in which novel, molecularly targeted cancer therapies can be used alone or in combination with immunotherapy in various tumor models (Molecular Immunotherapy Section, Cancer and Inflammation Program). -Understanding the genetic basis for resistance or susceptibility to disease conferred by human leukocyte antigen (HLA) class I and class II genes, which have a central role in the innate immune response (HLA Immunogenetics Section, Cancer and Inflammation Program). -Investigating the role of cytokines such as interleukin-7 (IL-7) in the development of T lymphocyte and natural killer (NK) cell lineages and their role in promoting cell survival, terminal differentiation, and apoptotic cell death (Immunological Cytokine Research Section, Cancer and Inflammation Program). -Examining the role of dendritic cells, other innate or adaptive effector cell types, and proinflammatory or immunoregulatory cytokines on carcinogenesis and cancer therapy (Cancer Immunobiology Section, Cancer and Inflammation Program). -Identifying and defining the molecular events that regulate lineage commitment and terminal differentiation of hemotopoietic stem cells (Hematopoiesis and Stem Cell Biology Section, Laboratory of Cancer Prevention). -Defining the cell surface markers, metastasis ability, and pathways for growth and self-renewal, of cancer stem cells from prostate, breast, glioma, and renal cell carcinomas (Cancer Stem Cell Section, Laboratory of Cancer Prevention). -Studying the role that epigenetic regulation plays in cellular differentiation, embryonic development, and tumorigenesis (Epigenetics Group, Laboratory of Cancer Prevention). -Understanding the structure and function of glycosyltransferases and developing novel glycosyltransferases for targeted drug delivery and contrast agents for medical imaging (Structural Glycobiology Section, CCR Nanobiology Program). -Developing highly efficient, state-of-the-art algorithms to discover the structural patterns of proteins and predict molecular associations (i.e., protein-protein interactions) in support of nanodesign for cancer diagnosis, therapy, and prevention (Computational Structural Biology Group, CCR Nanobiology Program). -Support in bioassay development and screening, natural products chemistry, protein chemistry, molecular biology, and high-content cellular imaging to facilitate multidisciplinary, molecular targets discovery research (Molecular Targets Laboratory). -Basic and applied chemistry support for studies characterizing the reactions of the bioregulatory agent nitric oxide (NO) with organic compounds (Chemistry Section, Chemical Biology Laboratory). -Discovery and characterization of renal carcinoma susceptibility genes (Urologic Oncology Research Group, Urologic Oncology Branch).

基础研究计划（BRP）为NCI的癌症研究中心（CCR）提供科学和技术专业知识，范围从癌症和人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征（AIDS），到癌症、传染病和自身免疫性疾病的基本细胞过程。BRP支持的研究课题包括：-研究如何在各种肿瘤模型中单独使用新颖的、分子靶向的癌症治疗方法或与免疫治疗联合使用（分子免疫治疗部分，癌症和炎症项目）。-了解人类白细胞抗原（HLA） I类和II类基因对疾病的抗性或易感性的遗传基础，这些基因在先天免疫反应中起着核心作用（HLA免疫遗传学部分，癌症和炎症项目）。-研究细胞因子如白细胞介素-7 （IL-7）在T淋巴细胞和自然杀伤（NK）细胞谱系发育中的作用，以及它们在促进细胞存活、终末分化和凋亡细胞死亡中的作用（免疫细胞因子研究部门，癌症和炎症项目）。-检查树突状细胞，其他先天或适应性效应细胞类型，促炎或免疫调节细胞因子在致癌和癌症治疗中的作用（癌症免疫生物学部分，癌症和炎症项目）。-识别和定义调节造血干细胞谱系承诺和终末分化的分子事件（造血和干细胞生物学部分，癌症预防实验室）。-确定来自前列腺癌、乳腺癌、胶质瘤和肾细胞癌的癌症干细胞的细胞表面标记物、转移能力以及生长和自我更新途径（癌症预防实验室癌症干细胞组）。-研究表观遗传调控在细胞分化、胚胎发育和肿瘤发生中的作用（癌症预防实验室表观遗传学组）。-了解糖基转移酶的结构和功能，开发用于靶向药物传递和医学成像造影剂的新型糖基转移酶（结构糖生物学部分，CCR纳米生物学项目）。-开发高效、先进的算法来发现蛋白质的结构模式和预测分子关联（即蛋白质-蛋白质相互作用），以支持用于癌症诊断、治疗和预防的纳米设计（计算结构生物学组，CCR纳米生物学计划）。支持生物检测开发和筛选，天然产物化学，蛋白质化学，分子生物学和高含量细胞成像，以促进多学科，分子靶点发现研究（分子靶点实验室）。-为生物调节剂一氧化氮（NO）与有机化合物的反应特性研究提供基础和应用化学支持（化学生物学实验室化学部分）。-肾癌易感基因的发现与表征（泌尿肿瘤学研究组，泌尿肿瘤学分会）