IRRADIATION SHARED RESOURCE

辐照共享资源

• 批准号: 8463392
• 负责人: Jack Hoopes
• 金额: $ 8.55万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463392
• 关键词: Animal Experiments; Animals; Budgets; Cancer Center Support Grant; Cancer Vaccines; Cardiac; Cell Culture Techniques; Cell Survival; Cells; Center Core Grants; Cesium; Clinical; Clinical Trials; Communities; Development; Dose-Rate; Electrons; Fee-for-Service Plans; Feedback; Fees; Goals; Hour; Image; Immunosuppression; Individual; Institution; Ionizing radiation; Irradiation Shared Resource; Laboratories; Linear Accelerator Radiotherapy Systems; Malignant Neoplasms; Mammalian Cell; Mission; Normal tissue morphology; Norris Cotton Cancer Center; Patients; Photons; Radiation; Radiosurgery; Relative (related person); Research; Research Personnel; Resources; Respiration; Rodent; Services; Source; Tube; base; cone-beam computed tomography; cost; cost effective; flasks; instrument; irradiation; meetings; neoplastic cell; research study; tumor

The primary mission of the Norris Cotton Cancer Center (NCCC) Irradiation Shared Resource (ISR) is to provide ionizing radiation services in support of basic and translational cell and animal experiments for the NCCC research community. The availability of a variety of radiation sources continues to allow the ISR to offer a broad and versatile irradiation capability with a wide range of energies and dose rates. The ISR operates multiple experimental and clinical irradiators, including a Cs-gamma source (12,000 Curie, Cs-137), an orthovoltage x-ray source (Pantak multiple energy, 300 KV x-irradiator), four linear accelerators from 6-20 MeV photons and 5-18 MeV electrons and an lr-192 high dose rate after-loader. Linear accelerator capabilities include Cone Beam CT, stereotactic radiosurgery and cardiac/respiration gated therapy. The ISR previously developed a number of advanced imaging instruments and services that now have been split off to constitute a developmental core in advanced animal imaging. The ISR currently provides 25 NCCC Pis and their laboratories with irradiation services. NCCC users represented 81% of the total laboratories using this facility at Dartmouth (25/31 labs total) for FY 2007, and their usage constituted 95% of the total based on units of use. Although the ISR provides critical support for certain NCCC projects and is cost-effective compared with the cost to individual labs to maintain and operate such irradiation sources independently, the overall user base is relatively small and specialized. Thus, the ISR requires a disproportionate level of support from the CCSG and other sources relative to its chargeback revenues. Fees are kept as low as practical, based on user feedback as to what researchers are able and willing to pay on a fee-for-service basis for these irradiations (e.g., fees would have to raise five-fold in order to recover total costs) and also based on comparisons with other institutions. Total chargebacks for this core were $15,466 for FY 2007, representing 17% of the total revenues, and the total operating budget was $91,869, requiring -$76,403 in subvention, derived from the NCCC Core Grant ($64,356, 70%) and other institutional resources ($12,047, 13%). The ISR is requesting a budget of $70,600 from the NCCC Core Grant for the first year of this renewal¿a level comparable to the current year's support¿for its total estimated operating budget for FY 2009 of approximately $89,523. The ISR continues to provide a variety of irradiation services for cell culture and experimental animal experiments to meet the needs of NCCC investigators, who are its principal users. The cesium irradiator continues to be the most heavily used irradiation service of the ISR. Although less heavily used, the clinical radiation sources have proved invaluable for specific projects, the overall goal of the ISR is to continue to support NCCC cancer researchers with these services at as low a rate as possible so that they can continue to successfully meet their research objectives individually and collectively.

诺里斯棉花癌症中心（NCCC）辐照共享资源（ISR）的主要使命是 提供电离辐射服务，以支持基本和转化细胞和动物实验， NCCC研究社区。各种辐射源的可用性继续使ISR能够 提供了一个广泛的和通用的辐射能力与广泛的能量和剂量率。的ISR 操作多个实验和临床辐照器，包括一个Cs-γ源（12，000居里，Cs-137）， 一个正电压x射线源（Pantak多能，300 KV x辐照器），4个6-20的直线加速器 MeV光子和5-18 MeV电子以及lr-192高剂量率后装弹。直线加速器 包括锥形束CT、立体定向放射外科和心脏/呼吸门控治疗。的ISR 以前开发了一些先进的成像仪器和服务，现在已经被分离出来， 构成了先进动物成像的发展核心。ISR目前提供25个NCCC PI 和他们的实验室提供辐照服务。NCCC用户占使用NCCC的实验室总数的81%。 2007财年，位于达特茅斯的该设施（31个实验室中的25个）的使用量占总使用量的95%， 使用单位。虽然ISR为某些NCCC项目提供关键支持，并且具有成本效益， 与单个实验室独立维护和操作这种辐射源的成本相比， 总的用户基础相对较小，而且比较专业。因此，ISR需要不成比例的 来自CCSG和其他来源的与其退款收入相关的支持。费用低至 实用，基于用户反馈，即研究人员能够并愿意为付费服务支付什么费用 这些照射的基础（例如，为了收回总成本，费用必须增加五倍）， 根据与其他机构的比较。2007财年，该核心的总退款额为15,466美元， 占总收入的17%，总运营预算为91，869美元，需要-76，403美元， 补助金，来自NCCC核心补助金（64，356美元，70%）和其他机构资源（12，047美元， 13%）。ISR要求从NCCC核心补助金中获得70，600美元的预算，用于本项目的第一年。 更新<$相当于本年度的支持水平<$其财政年度的总估计业务预算 2009年约89，523美元。ISR继续为细胞培养提供各种辐照服务 和实验动物实验，以满足NCCC调查人员的需要，他们是它的主要用户。 铯辐照器仍然是ISR使用最多的辐照服务。尽管较不 大量使用，临床辐射源已被证明是非常宝贵的具体项目， ISR将继续以尽可能低的费用支持NCCC癌症研究人员 以便他们能够继续单独和集体地成功实现他们的研究目标。