IRRADIATION SHARED RESOURCE

诺里斯棉花癌症中心(NCCC)辐射共享资源(ISR)的主要任务是 提供电离辐射服务，以支持基础和翻译细胞和动物实验 NCCC研究社区。各种放射源的可获得性继续使ISR能够 提供广泛和多功能的辐射能力，具有广泛的能量和剂量率。ISR 运营多个实验和临床辐照装置，包括一个Cs-伽马源(12,000居里，Cs-137)， 一个正压x射线源(Pantak多能量，300kv x射线)，4个直线加速器，从6-20 MeV光子和5-18 MeV电子和一台LR-192高剂量率后加载器。直线加速器 其能力包括锥束CT、立体定向放射外科和心脏/呼吸门控治疗。ISR 以前开发了许多先进的成像仪器和服务，现在已经剥离 在先进的动物成像中构成发育核心。ISR目前提供25个NCCC PI 和他们的实验室提供辐射服务。NCCC用户占实验室总数的81% 达特茅斯的这一设施(总共25/31个实验室)2007财年，其使用量占总数的95%，基于 使用单位。尽管ISR为某些NCCC项目提供关键支持并具有成本效益 与个别实验室独立维护和操作这些辐射源的成本相比， 总体来说，用户群相对较小，而且比较专业化。因此，ISR需要不成比例的 CCSG和其他来源对其按存储容量使用计费收入的支持。费用保持在最低的 实用，基于用户关于研究人员能够和愿意为服务付费支付的反馈 这些辐射的基础(例如，必须将费用提高五倍才能收回总成本) 基于与其他机构的比较。2007财年，此核心的总退款为15,466美元， 占总收入的17%，业务预算总额为91,869美元，需要--76,403美元 补助金，来自NCCC核心补助金(64 356美元，70%)和其他机构资源(12 047美元， 13%)。ISR要求从NCCC核心拨款中为今年第一年提供70,600美元的预算 续订相当于本年度支助的财政年度总业务预算估计数 2009年约为89,523美元。ISR继续为细胞培养提供各种辐照服务 以及实验动物实验，以满足NCCC调查人员的需求，他们是NCCC的主要用户。 铯辐照器仍然是ISR使用量最大的辐照服务。尽管数量较少 大量使用，临床放射源已被证明对特定项目非常有价值，总体目标是 ISR将继续以尽可能低的费率为NCCC癌症研究人员提供这些服务 以便他们能够继续成功地单独和集体地实现他们的研究目标。

The primary mission of the Norris Cotton Cancer Center (NCCC) Irradiation Shared Resource (ISR) is to provide ionizing radiation services in support of basic and translational cell and animal experiments for the NCCC research community. The availability of a variety of radiation sources continues to allow the ISR to offer a broad and versatile irradiation capability with a wide range of energies and dose rates. The ISR operates multiple experimental and clinical irradiators, including a Cs-gamma source (12,000 Curie, Cs-137), an orthovoltage x-ray source (Pantak multiple energy, 300 KV x-irradiator), four linear accelerators from 6-20 MeV photons and 5-18 MeV electrons and an lr-192 high dose rate after-loader. Linear accelerator capabilities include Cone Beam CT, stereotactic radiosurgery and cardiac/respiration gated therapy. The ISR previously developed a number of advanced imaging instruments and services that now have been split off to constitute a developmental core in advanced animal imaging. The ISR currently provides 25 NCCC Pis and their laboratories with irradiation services. NCCC users represented 81% of the total laboratories using this facility at Dartmouth (25/31 labs total) for FY 2007, and their usage constituted 95% of the total based on units of use. Although the ISR provides critical support for certain NCCC projects and is cost-effective compared with the cost to individual labs to maintain and operate such irradiation sources independently, the overall user base is relatively small and specialized. Thus, the ISR requires a disproportionate level of support from the CCSG and other sources relative to its chargeback revenues. Fees are kept as low as practical, based on user feedback as to what researchers are able and willing to pay on a fee-for-service basis for these irradiations (e.g., fees would have to raise five-fold in order to recover total costs) and also based on comparisons with other institutions. Total chargebacks for this core were $15,466 for FY 2007, representing 17% of the total revenues, and the total operating budget was $91,869, requiring -$76,403 in subvention, derived from the NCCC Core Grant ($64,356, 70%) and other institutional resources ($12,047, 13%). The ISR is requesting a budget of $70,600 from the NCCC Core Grant for the first year of this renewal¿a level comparable to the current year's support¿for its total estimated operating budget for FY 2009 of approximately $89,523. The ISR continues to provide a variety of irradiation services for cell culture and experimental animal experiments to meet the needs of NCCC investigators, who are its principal users. The cesium irradiator continues to be the most heavily used irradiation service of the ISR. Although less heavily used, the clinical radiation sources have proved invaluable for specific projects, the overall goal of the ISR is to continue to support NCCC cancer researchers with these services at as low a rate as possible so that they can continue to successfully meet their research objectives individually and collectively.