Comparative Biology of Tissue Repair, Regeneration and Aging

组织修复、再生和衰老的比较生物学

• 批准号: 8432228
• 负责人: KEVIN STRANGE
• 金额: $ 271.32万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432228
• 关键词: Address; Advisory Committees; Aging; Animal Model; Animals; Biological; Biology; Biology of Aging; Biomedical Research; Centers of Research Excellence; Commit; Communities; Comparative Biology; Comparative Study; Computational Molecular Biology; Core Facility; Data; Data Analyses; Data Set; Development; Development Plans; Environment; Evaluation; Evolution; Faculty; Fellowship; Fellowship Program; Funding; Funding Opportunities; Genes; Genetic; Genetic Variation; Genomics; Goals; Growth; Growth and Development function; Health; Hematopoietic stem cells; Homeostasis; Housing; Human; Interdisciplinary Study; Invertebrates; Island; Laboratories; Leadership; Limb structure; Longevity; Maine; Mammals; Marines; Medicine; Mentors; Modeling; Molecular; Mus; Natural regeneration; Nature; Online Systems; Organism; Outcome; Physicians; Physiological; Process; Publishing; Recording of previous events; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Sensory; Services; Somatic Mutation; Speed; Stress; System; Technology; Tissues; Vertebrates; Vision; Visit; Whole Organism; Work; Zebrafish; age effect; axon regeneration; career development; comparative; cost; data management; functional genomics; gene environment interaction; human disease; improved; in vivo; in vivo Model; innovation; insight; novel; preference; programs; public health relevance; regenerative; response; success; tissue regeneration; tissue repair; tool

DESCRIPTION (provided by applicant): This application proposes to create an innovative Center of Biomedical Research Excellence (COBRE) focused on the Comparative Biology of Tissue Repair, Regeneration and Aging. Tissue regeneration in mammals is extremely limited. However, robust regeneration is the norm for countless lower vertebrates and invertebrates. In addition, nature has endowed diverse animals with remarkable longevity and robust tissue repair mechanisms that slow aging-induced degenerative processes. The COBRE research theme uniquely focuses on using diverse non-mammalian and mammalian model organisms together with comparative biology approaches to address several overarching and fundamental questions in the field of regenerative biology that can only be addressed at the level of the whole organism. This research focus represents a cornerstone of the long term strategic scientific Vision of the Mount Desert Island Biological Laboratory (MDIBL), and builds on the MDIBL and Maine INBRE success stories and on MDIBL's longstanding and increasingly important expertise in comparative biomedical research. The four proposed COBRE projects have extensive points of intersection and interaction and focus on defining mechanisms of limb and sensory axon regeneration in zebrafish, the impact of aging and somatic mutation load on mouse hematopoietic stem cell tissue homeostasis, and the effects of aging and stress on zebrafish tissue regeneration. Proposed scientific cores will provide essential services and resources to Project Leaders and will be valuable to a larger scientific community. The Comparative Animal Models Core will provide COBRE investigators with resources necessary to utilize diverse non-mammalian animal models in regenerative and aging biology research. The Comparative Functional Genomics Core will provide data management and analysis expertise to COBRE investigators. It will also develop a novel web-based resource that integrates data generated by COBRE investigators with published data sets in order to provide a systems-level view of regeneration that will inform new hypotheses about how genes regulate regenerative responses in diverse organisms. The Administrative Core will provide administrative, scientific, and fiscal leadership; implement a career development plan for junior faculty that facilitates their transition to independence; and implement an evaluation strategy to assess the progress of the COBRE in accomplishing its goals. The proposed COBRE will greatly enhance MDIBL's growth and development, which in turn will contribute to the continued growth and enhancement of the biomedical research infrastructure in Maine.

描述（由申请人提供）：本申请提议创建一个创新的生物医学研究卓越中心（COBRE），专注于组织修复，再生和衰老的比较生物学。哺乳动物的组织再生极为有限。然而，强健的再生是无数低等脊椎动物和无脊椎动物的常态。此外，大自然赋予各种动物非凡的寿命和强大的组织修复机制，以减缓衰老引起的退化过程。COBRE的研究主题独特地侧重于使用不同的非哺乳动物和哺乳动物模式生物以及比较生物学方法来解决再生生物学领域的几个首要和基本问题，这些问题只能在整个生物体的水平上解决。这一研究重点是荒漠岛山生物实验室（MDIBL）长期战略科学愿景的基石，并建立在MDIBL和缅因州INBRE的成功案例以及MDIBL在比较生物医学研究方面长期且日益重要的专业知识的基础上。这四个COBRE项目具有广泛的交叉点和相互作用，重点研究斑马鱼肢体和感觉轴突再生的机制，衰老和体细胞突变负荷对小鼠造血干细胞组织稳态的影响，以及衰老和应激对斑马鱼组织再生的影响。拟议的科学核心将为项目负责人提供必要的服务和资源，并将对更大的科学界有价值。比较动物模型核心将为COBRE研究人员提供必要的资源，以便在再生和衰老生物学研究中利用各种非哺乳动物模型。比较功能基因组学核心将为COBRE研究人员提供数据管理和分析专业知识。它还将开发一种新的基于网络的资源，将COBRE研究人员生成的数据与已发表的数据集集成在一起，以提供再生的系统级视图，从而为有关基因如何调节不同生物体的再生反应提供新的假设。行政核心将提供行政、科学和财政领导；为初级教师实施职业发展计划，促进他们向独立过渡；实施评估战略，以评估COBRE在实现其目标方面的进展。拟议的COBRE将极大地促进MDIBL的增长和发展，这反过来又将有助于缅因州生物医学研究基础设施的持续增长和增强。