Core B - Nanomaterials

拟议的核心B将发挥三个主要作用。首先，它将为每个项目开发用于药物输送的纳米材料。这将包括用于药物、放射性制药和蛋白质输送的新的纳米载体，并包括可切割的多嵌段HPMA共聚物(项目6)、定向HPMA共聚-药物结合物(项目9)和蛋白质纳米载体(项目7、8和10)。第二，核心将协助中心的科学家对纳米材料进行全面和深入的表征。综合表征技术包括：动态光散射；Zeta电位测量；分析超速离心法；表面等离子激元共振；原子力显微镜；透射电子显微镜；电感耦合等离子体质谱和荧光光谱。第三，核心将使用各自的细胞系和动物模型来评估所有新合成纳米材料的安全性，核心将为所有研究人员提供用于生物用途的受控和标准化材料。

The proposed Core B will serve three primary functions. First, it will develop nanoscale materials for drug delivery for each of the projects. This will include new nanocarriers for drug, radiopharmaceutics and protein delivery, and include cleavable multi-block HPMA copolymers (Project 6), targeted HPMA copolymer-drug conjugates (Project 9), and protein nanocarriers (Project 7, 8, and 10). Second, the Core will assist the Center's scientists in comprehensive and in-depth characterization of the nanomaterials. The combined characterization techniques include the following: dynamic light scattering; zeta-potential measurements; analytical ultracentrifugation; surface plasmon resonance; atomic force microscopy; transmission electron microscopy; inductively coupled plasma mass spectroscopy, and fluorescence spectroscopy. Third, the Core will evaluate safety of all new synthesized nanomaterials using the respective cell lines and animal models, and the Core will provide all investigators with controlled and standardized materials for biological use.