Nebraska Center for Nanomedicine

描述（由申请人提供）：多学科的内布拉斯加州纳米医学中心（NCN），成立于2008年与生物医学研究卓越中心（COBRE）的资金，正在建立一个国家和国际公认的卓越的纳米医学计划，结合了材料，制药和生物科学的广泛专业知识，由创新研究驱动。NCN已经完成了其最初的目标，并通过建立强大的合作研究计划的战略联系基础设施，并通过指导有才华的初级教师干部独立成功，提高了内布拉斯加州的生物医学研究能力。 26名NCN成员（所有COBRE关键人员）共有292篇出版物（包括86篇由指导的初级教师），沿着99项新专利申请和46项赠款（16项与纳米医学有关）。这个NCN COBRE延续提案详细说明了我们继续建设和维持一个全国知名和国际认可的生物医学研究中心的计划。NCN在未来五年内实现这些目标的具体目标是：1）通过支持五个主题相关的项目和指导初级教师成为独立调查员，继续扩大现有的研究优势;（二）通过试点项目计划和经验丰富的研究人员对创新项目的支持来提高研究能力，重点是扩大翻译能力和临床研究合作; 3）继续有针对性的教师招聘，以扩大纳米医学研究领域的范围和专业知识;和4）维持必要的科学核心设施的支持，作为平台，以提高NCN成员成功竞争NIH资金的能力。这些目标的实现将使NCN从第二阶段资助中脱颖而出，成为纳米医学卓越研究的自我维持中心，通过个人和多研究者，整个项目的研究赠款，提高了寻求项目支持的能力。通过开发和临床转化用于诊断和治疗人类疾病的有效纳米药物，NCN最终将为内布拉斯加人和整个社会的健康提供重大利益。

DESCRIPTION (provided by applicant): The multidisciplinary Nebraska Center for Nanomedicine (NCN), established in 2008 with Center for Biomedical Research Excellence (COBRE) funding, is building a nationally and internationally recognized program of excellence in nanomedicine that combines broad expertise in material, pharmaceutical and biological sciences driven by innovative research. NCN has completed its original objectives and enhanced Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong collaborative research programs and by mentoring a cadre of talented junior faculty to independent success. 26 NCN members (all COBRE key personnel) have a total of 292 publications (including 86 by mentored junior faculty), 99 new patent applications along with 46 grants (16 related to nanomedicine). This NCN COBRE continuation proposal details our plan to continue building and to sustain a biomedical research center of national prominence and international recognition. The specific aims that move the NCN toward these goals over the next five years are: 1) continue to expand existing research strengths through the support of five thematically linked projects and mentorship of junior faculty into independent investigators; 2) grow research capacity through the pilot project program and the support of innovative projects by experienced researchers with a focus on expanding translational capabilities and clinical research collaborations; 3) continue targeted faculty recruitment to broaden the scope and expertise in the area of nanomedicine research; and 4) sustain the support of essential scientific core facilities, which serve as platforms to increase the capacity f NCN members to compete successfully for NIH funding. The realization of these aims will allow the NCN to emerge from Phase II funding as self-sustaining center of research excellence in nanomedicine, with an increased capacity to pursue programmatic support through individual and multi-investigator, program-wide research grants. Through the development and clinical translation of effective nanomedicines for diagnosis and therapy for human diseases, the NCN will ultimately provide significant benefits for the health of Nebraskans and society at large.