Nebraska Center for Nanomedicine

描述（由申请人提供）：多学科内布拉斯加州纳米医学中心（NCN）成立于2008年，由生物医学研究卓越中心（COBRE）资助，正在建立一个国家和国际公认的纳米医学卓越计划，该计划结合了创新研究驱动的材料，制药和生物科学方面的广泛专业知识。NCN已经完成了最初的目标，并通过创建强大的合作研究项目的战略联系基础设施和指导有才华的初级教师骨干独立成功，增强了内布拉斯加州的生物医学研究能力。26名NCN成员（均为COBRE关键人员）共有292篇出版物（包括86篇受指导的初级教师），99项新专利申请以及46项授权（16项与纳米医学有关）。这个NCN COBRE延续提案详细说明了我们继续建设和维持一个国家突出和国际认可的生物医学研究中心的计划。NCN在未来五年内实现这些目标的具体目标是：1)通过支持五个主题相关的项目和指导初级教师成为独立研究者，继续扩大现有的研究优势；2)通过试点项目计划和经验丰富的研究人员对创新项目的支持来提高研究能力，重点是扩大转化能力和临床研究合作；3)继续有针对性地招聘教师，以扩大纳米医学研究领域的范围和专业知识；4)维持对基本科学核心设施的支持，这些设施作为平台，可以提高NCN成员成功竞争NIH资助的能力。这些目标的实现将使NCN从第二阶段的资助中脱颖而出，成为自我维持的纳米医学卓越研究中心，并具有通过个人和多研究者、项目范围的研究资助寻求项目支持的更大能力。通过开发和临床转化用于诊断和治疗人类疾病的有效纳米药物，纳米网络最终将为内布拉斯加人和整个社会的健康提供重大利益。

DESCRIPTION (provided by applicant): The multidisciplinary Nebraska Center for Nanomedicine (NCN), established in 2008 with Center for Biomedical Research Excellence (COBRE) funding, is building a nationally and internationally recognized program of excellence in nanomedicine that combines broad expertise in material, pharmaceutical and biological sciences driven by innovative research. NCN has completed its original objectives and enhanced Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong collaborative research programs and by mentoring a cadre of talented junior faculty to independent success. 26 NCN members (all COBRE key personnel) have a total of 292 publications (including 86 by mentored junior faculty), 99 new patent applications along with 46 grants (16 related to nanomedicine). This NCN COBRE continuation proposal details our plan to continue building and to sustain a biomedical research center of national prominence and international recognition. The specific aims that move the NCN toward these goals over the next five years are: 1) continue to expand existing research strengths through the support of five thematically linked projects and mentorship of junior faculty into independent investigators; 2) grow research capacity through the pilot project program and the support of innovative projects by experienced researchers with a focus on expanding translational capabilities and clinical research collaborations; 3) continue targeted faculty recruitment to broaden the scope and expertise in the area of nanomedicine research; and 4) sustain the support of essential scientific core facilities, which serve as platforms to increase the capacity f NCN members to compete successfully for NIH funding. The realization of these aims will allow the NCN to emerge from Phase II funding as self-sustaining center of research excellence in nanomedicine, with an increased capacity to pursue programmatic support through individual and multi-investigator, program-wide research grants. Through the development and clinical translation of effective nanomedicines for diagnosis and therapy for human diseases, the NCN will ultimately provide significant benefits for the health of Nebraskans and society at large.