Nebraska Center for Nanomedicine

描述(由申请者提供)：内布拉斯加州多学科纳米医学中心(NCN)成立于2008年，由生物医学卓越研究中心(Cobre)资助，正在建设一个国家和国际公认的纳米医学卓越计划，该计划结合了材料、制药和生物科学方面的广泛专业知识，由创新研究驱动。NCN已经完成了其最初的目标，并通过创建具有战略联系的强大合作研究计划的基础设施，并通过指导一批有才华的初级教员取得独立成功，提高了内布拉斯加州的生物医学研究能力。26个NCN成员(都是Cobre的关键人员)总共发表了292篇论文(包括86篇由初级指导教师提出的文章)，99项新的专利申请以及46项授权(16项与纳米医学有关)。这份NCN Cobre续建提案详细说明了我们继续建设和维持一个具有全国知名度和国际认知度的生物医学研究中心的计划。未来五年，NCN朝着这些目标迈进的具体目标是：1)通过支持五个主题相关的项目和将初级教员指导为独立研究人员，继续扩大现有的研究实力；2)通过试点项目计划和经验丰富的研究人员对创新项目的支持，提高研究能力，重点是扩大翻译能力和临床研究合作；3)继续有针对性地招聘教员，以扩大纳米医学研究领域的范围和专业知识；以及4)继续支持必要的科学核心设施，作为提高NCN成员成功竞争NIH资金的能力的平台。这些目标的实现将使NCN能够从第二阶段的资助中脱颖而出，成为纳米医学卓越研究的自给自足的中心，并增强通过个人和多名研究人员、整个计划范围的研究拨款寻求计划支持的能力。通过开发和临床转化用于诊断和治疗人类疾病的有效纳米药物，NCN最终将为内布拉斯加州人和整个社会的健康提供重大好处。

DESCRIPTION (provided by applicant): The multidisciplinary Nebraska Center for Nanomedicine (NCN), established in 2008 with Center for Biomedical Research Excellence (COBRE) funding, is building a nationally and internationally recognized program of excellence in nanomedicine that combines broad expertise in material, pharmaceutical and biological sciences driven by innovative research. NCN has completed its original objectives and enhanced Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong collaborative research programs and by mentoring a cadre of talented junior faculty to independent success. 26 NCN members (all COBRE key personnel) have a total of 292 publications (including 86 by mentored junior faculty), 99 new patent applications along with 46 grants (16 related to nanomedicine). This NCN COBRE continuation proposal details our plan to continue building and to sustain a biomedical research center of national prominence and international recognition. The specific aims that move the NCN toward these goals over the next five years are: 1) continue to expand existing research strengths through the support of five thematically linked projects and mentorship of junior faculty into independent investigators; 2) grow research capacity through the pilot project program and the support of innovative projects by experienced researchers with a focus on expanding translational capabilities and clinical research collaborations; 3) continue targeted faculty recruitment to broaden the scope and expertise in the area of nanomedicine research; and 4) sustain the support of essential scientific core facilities, which serve as platforms to increase the capacity f NCN members to compete successfully for NIH funding. The realization of these aims will allow the NCN to emerge from Phase II funding as self-sustaining center of research excellence in nanomedicine, with an increased capacity to pursue programmatic support through individual and multi-investigator, program-wide research grants. Through the development and clinical translation of effective nanomedicines for diagnosis and therapy for human diseases, the NCN will ultimately provide significant benefits for the health of Nebraskans and society at large.