Longitudinal Examination of Human Amygdala-vmPFC Development

人类杏仁核-vmPFC发育的纵向检查

• 批准号: 8282800
• 负责人: Nim Tottenham
• 金额: $ 26.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8282800
• 关键词: Address; Adolescence; Adolescent; Adult; Adverse event; Age; Amygdaloid structure; Animals; Anterior; Anxiety; Behavioral; Biological; Biological Markers; Biology; Bipolar Disorder; Child; Childhood; Coupled; Data; Development; Emotional; Emotions; Environment; Environmental Exposure; Environmental Risk Factor; Failure; Functional Magnetic Resonance Imaging; Hares; Human; Human Development; Individual; Life; Literature; Magnetic Resonance Imaging; Maps; Measures; Mental Depression; Mental Health; Mental disorders; Neurobiology; Orphanages; Personality Disorders; Population; Predisposing Factor; Prefrontal Cortex; Prevention; Problem behavior; Process; Psychopathology; Recruitment Activity; Regulation; Relative (related person); Research; Role; Schizophrenia; Shapes; Stress; Structure; Time; TimeLine; behavior measurement; caregiving; cingulate cortex; cohort; design; early adolescence; emotional stimulus; experience; high risk; human data; infancy; longitudinal design; neural circuit; neurodevelopment; neuroimaging; postnatal; prevent; programs; prospective; public health relevance

DESCRIPTION (provided by applicant): The primary aim of this proposal is to investigate the normative development of the neurobiology that results in mental illness associated with emotional difficulties including high reactivity and poor regulation. Such illnesses include, but are not limited to, anxiety, depression, schizophrenia, bipolar disorder, sociopathy, and personality disorders. A failure to effectively recruit a neural circuitry that includes the amygdala and ventromedial prefrontal cortex has been implicated in these mental illnesses in adults. The present research strategy, which uses structural and functional magnetic resonance imaging (MRI) and behavioral measures, will employ a prospective and longitudinal design that identifies biomarkers associated with these difficulties and map their development as children age into adolescence. The second aim is to examine the influence of early adverse caregiving environments on the development of this neurobiology. For long, it has been recognized that environmental stress is associated with a disproportionately high of risk emotional psychopathology. A large animal literature combined with an emerging human neuroimaging literature shows that environmental stress can impair mental health functioning via disruption of the amygdala and the regulatory processes that depend on proper connectivity between amygdala and ventromedial prefrontal cortex. When stress exposure occurs prior to developmental maturity, the effects can be more potent and its impact longer lasting than stress that occurs in adulthood. Therefore, the findings of this project will have a high impact on the field of mental health by identifying biomarkers associated with emotional difficulties prior to their behavioral onset. In this way, we will be better at predicting and preventing the development of mental illnesses that often emerge during the adolescent period. PUBLIC HEALTH RELEVANCE: This project will examine the development of a specific neurobiology that is associated with emotional difficulties such as high reactivity and poor regulation. In addition to mapping out the typical development of this biology, this project will examine the role that adverse early caregiving has on its development. This research is important because identification of biomarkers during development before they emerge into problem behaviors in adulthood will help in the prevention of mental illnesses associated with emotional difficulties.

描述（由申请人提供）：该提案的主要目的是研究神经生物学的规范性发展，导致精神疾病与情感困难相关，包括高反应性和调节不良。这些疾病包括但不限于焦虑，抑郁，精神分裂症，躁郁症，社会病和人格障碍。未能有效募集包括杏仁核和腹膜前额叶皮层在内的神经回路已与成人的这些精神疾病有关。本研究策略使用结构和功能磁共振成像（MRI）和行为措施，将采用一种前瞻性和纵向设计，可以识别与这些困难相关的生物标志物，并随着儿童年龄的增长而绘制其发展。第二个目的是研究早期不良护理环境对这种神经生物学发展的影响。长期以来，人们已经认识到，环境压力与风险不成比例的情绪心理病理学有关。大型动物文献与新兴的人类神经影像学文献相结合表明，环境压力会通过破坏杏仁核和依赖于杏仁核和腹膜前额叶前额叶皮质之间正确连通性而损害心理健康功能。当发生在发育成熟之前发生压力时，其影响可能更有效，其影响比成年时发生的压力更长。因此，该项目的发现将通过在行为发作之前识别与情绪困难相关的生物标志物来对心理健康领域产生重大影响。这样，我们将更好地预测和防止在青少年时期出现的精神疾病的发展。 公共卫生相关性：该项目将研究特定神经生物学的发展，该学与情感上的困难相关，例如高反应性和调节不良。除了绘制该生物学的典型发展外，该项目还将研究不良早期护理在其发展中的作用。这项研究很重要，因为在成年期间生物标志物在发展中的生物标志物中鉴定出来，这将有助于预防与情绪困难相关的精神疾病。