Replacement of Cage and Rack Wash System at Brown University's BioMedical Center

描述(申请人提供)：这个G20项目的总体目标是通过用新的型号Basil Steris 4700笼架洗涤系统取代已有24年历史的Basil Steris 4600机架洗涤系统，对主要生物医学中心动物设施的笼子洗涤系统进行现代化改造。通过在该垫圈完全失效之前更换该垫圈，我们的目标是保持Brown的AAALAC国际认证动物护理和使用计划的质量和完整性，继续保持并超过有效科学研究所需的动物护理标准。它的有用之处即将结束 在日常生活中，4600机架洗涤系统越来越多地离线维修，现在需要更换过时的部件。这种“4600”的主动更替将维持和提高Brown动物研究项目的研究实践和生产率，通过及时更换笼子提供与保持动物健康状态一致的物理植物环境和设备冗余，并为其提供所需的设备冗余。现代化的笼架清洗系统还包括更换两辆最旧的笼式洗涤车和小规模的公用事业翻新，通过持续和及时的实体植物改进，保持和提高动物护理设施的运营效率和工作人员生产力。它将建立一个现代化的基础设施，以促进稳定、安全和可靠的研究环境，为布朗动物研究实验室提供至关重要的笼子清洗服务能力和冗余。布朗的动物保护计划的年度运营预算约为200万美元，生物医学中心设施目前支持29名研究人员，每年直接资助约980万美元。这一设施的改进将支持我们广泛和协作的科学界中多个学术部门、学校、医院和合作小公司的研究和教育活动，并允许这些研究计划的继续扩大。通过支持布朗的联邦资助的研究和发现计划，生物医学设施的改进与布朗的使命相一致，即通过研究生物生存和福祉所依赖的行为和生物过程来促进对生物的理解。获奖将极大地促进罗德岛以及区域、国家和全球层面的人类健康相关研究。

DESCRIPTION (provided by applicant): The overall objective of this G20 project is to modernize the cage wash system in the primary BioMedical Center animal facility by replacing the 24 year old Basil Steris 4600 Rack Wash system with a new model Basil Steris 4700 Cage and Rack Wash system. By replacing this Rack Washer before it fails completely we aim to uphold the quality and integrity of Brown's AAALAC International certified animal care and use program by continuing, without major interruption or disruption, to maintain and exceed the standards of animal care necessary for effective scientific research. Nearing the end of its useful life, the 4600 Rack Wash system has increasingly been offline for repairs and now requires replacement parts that are obsolete. This proactive replacement of the "4600" will sustain and enhance the research practices and productivity of Brown's animal research programs by providing the physical plant environment and equipment redundancy consistent with, and required for, maintaining animals in a state of well-being through timely cage changing. A modernized Cage and Rack wash system, which also includes replacement of two of the oldest cage wash carts and minor utility renovations, will maintain and improve operational efficiency and staff productivity within the animal care facility by continuous and timely physical plant improvement. It will establish a modernized infrastructure that will facilitate a stable, secure an reliable research environment, providing Brown animal research laboratories with critically necessary cage wash service capacity and redundancy. The Animal Care Program at Brown has an annual operating budget of approximately $2M and the BioMedical Center facility currently supports 29 investigators with ~$9.8M in annual direct funding. This facility improvement will support research and educational activities in multiple academic departments, schools, hospitals and collaborating small companies within our broad and collaborative scientific community and allow continued expansion of these research programs. By supporting Brown's federally funded research and discovery programs, the BioMedical facility improvement is aligned with Brown's mission to advance the understanding of living organisms through studies of the behavioral and biological processes upon which their survival and well-being depends. An award would greatly facilitate human health-related research in Rhode Island and at the regional, national, and global level.